Gene Page: ERBB2
Summary ?
| GeneID | 2064 |
| Symbol | ERBB2 |
| Synonyms | CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1 |
| Description | erb-b2 receptor tyrosine kinase 2 |
| Reference | MIM:164870|HGNC:HGNC:3430|Ensembl:ENSG00000141736|HPRD:01281|Vega:OTTHUMG00000179300 |
| Gene type | protein-coding |
| Map location | 17q12 |
| Pascal p-value | 0.008 |
| Fetal beta | -0.108 |
| Support | CELL ADHESION AND TRANSSYNAPTIC SIGNALING CompositeSet Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenics,schizophrenias | Click to show details |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 6 | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 5.3826 |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ERBB2 | chr17 | 37883770 | G | A | NM_001005862 NM_004448 | p.1098V>I p.1128V>I | missense missense | Schizophrenia | DNM:Fromer_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PSMA2 | 0.93 | 0.92 |
| DIABLO | 0.93 | 0.92 |
| IFT52 | 0.92 | 0.94 |
| POLB | 0.92 | 0.93 |
| ALKBH2 | 0.92 | 0.92 |
| PHF5A | 0.91 | 0.90 |
| CCT7 | 0.91 | 0.88 |
| BTF3 | 0.91 | 0.91 |
| TSG101 | 0.91 | 0.93 |
| C14orf166 | 0.91 | 0.89 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.27 | -0.68 | -0.79 |
| AF347015.15 | -0.67 | -0.80 |
| AF347015.33 | -0.67 | -0.78 |
| AF347015.8 | -0.67 | -0.78 |
| MT-CYB | -0.66 | -0.78 |
| MT-CO2 | -0.65 | -0.74 |
| AF347015.26 | -0.65 | -0.81 |
| TINAGL1 | -0.65 | -0.75 |
| HLA-F | -0.65 | -0.72 |
| AF347015.2 | -0.64 | -0.79 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IEA | neurite (GO term level: 8) | - |
| GO:0000166 | nucleotide binding | IEA | - | |
| GO:0005006 | epidermal growth factor receptor activity | NAS | 15504738 | |
| GO:0004888 | transmembrane receptor activity | IDA | 7514177 | |
| GO:0004716 | receptor signaling protein tyrosine kinase activity | TAS | 10851066 | |
| GO:0005509 | calcium ion binding | IEA | - | |
| GO:0005524 | ATP binding | IEA | - | |
| GO:0004713 | protein tyrosine kinase activity | IEA | - | |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | IDA | 10485918 | |
| GO:0016740 | transferase activity | IEA | - | |
| GO:0019838 | growth factor binding | IDA | 7514177 | |
| GO:0042802 | identical protein binding | IPI | 16843263 | |
| GO:0043125 | ErbB-3 class receptor binding | TAS | 9590694 | |
| GO:0046982 | protein heterodimerization activity | IDA | 10572067 | |
| GO:0046982 | protein heterodimerization activity | NAS | 15504738 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0008045 | motor axon guidance | IEA | neuron, axon (GO term level: 14) | - |
| GO:0042552 | myelination | IEA | neuron, axon, Brain, oligodendrocyte (GO term level: 13) | - |
| GO:0007528 | neuromuscular junction development | IEA | Synap (GO term level: 10) | - |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IDA | 10485918 | |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | NAS | 15609325 | |
| GO:0006468 | protein amino acid phosphorylation | IEA | - | |
| GO:0008283 | cell proliferation | TAS | 10851066 | |
| GO:0007507 | heart development | IEA | - | |
| GO:0007507 | heart development | TAS | 15504738 | |
| GO:0007422 | peripheral nervous system development | IEA | - | |
| GO:0048015 | phosphoinositide-mediated signaling | NAS | 15504738 | |
| GO:0014065 | phosphoinositide 3-kinase cascade | IDA | 7556068 | |
| GO:0042060 | wound healing | IDA | 12646923 | |
| GO:0033088 | negative regulation of immature T cell proliferation in the thymus | IEA | - | |
| GO:0030879 | mammary gland development | TAS | 15504738 | |
| GO:0043406 | positive regulation of MAP kinase activity | IDA | 10572067 | |
| GO:0045785 | positive regulation of cell adhesion | IDA | 7556068 | |
| GO:0045765 | regulation of angiogenesis | NAS | 15609325 | |
| GO:0050679 | positive regulation of epithelial cell proliferation | IDA | 10572067 | |
| GO:0046777 | protein amino acid autophosphorylation | IDA | 7556068 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0043235 | receptor complex | IDA | Neurotransmitter (GO term level: 4) | 7514177 |
| GO:0043235 | receptor complex | TAS | Neurotransmitter (GO term level: 4) | 7556068 |
| GO:0005576 | extracellular region | IDA | 10485918 | |
| GO:0005737 | cytoplasm | IEA | - | |
| GO:0016020 | membrane | IEA | - | |
| GO:0016021 | integral to membrane | NAS | 15609325 | |
| GO:0005886 | plasma membrane | NAS | 12000754 | |
| GO:0016323 | basolateral plasma membrane | IDA | 12646923 | |
| GO:0016324 | apical plasma membrane | IEA | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| AGTR2 | AT2 | ATGR2 | MRX88 | angiotensin II receptor, type 2 | - | HPRD | 10710290 |
| BTC | - | betacellulin | - | HPRD | 9662041 |
| CAV1 | CAV | MSTP085 | VIP21 | caveolin 1, caveolae protein, 22kDa | - | HPRD | 9685399 |
| CD44 | CDW44 | CSPG8 | ECMR-III | HCELL | IN | LHR | MC56 | MDU2 | MDU3 | MGC10468 | MIC4 | MUTCH-I | Pgp1 | CD44 molecule (Indian blood group) | Affinity Capture-Western | BioGRID | 12093135 |
| CD82 | 4F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27 | CD82 molecule | - | HPRD,BioGRID | 14576349 |
| CDC37 | P50CDC37 | cell division cycle 37 homolog (S. cerevisiae) | An unspecified isoform of ERBB2 interacts with P50CDC37. This interaction was modelled on a demonstrated interaction between human ERBB2 and monkey P50CDC37. | BIND | 15643424 |
| CTNNB1 | CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923 | catenin (cadherin-associated protein), beta 1, 88kDa | - | HPRD,BioGRID | 7702605 |
| DDX10 | HRH-J8 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | ErbB-2 interacts with the DDX10 locus. | BIND | 15380516 |
| DLG4 | FLJ97752 | FLJ98574 | PSD95 | SAP90 | discs, large homolog 4 (Drosophila) | - | HPRD,BioGRID | 10839362 |
| EGF | HOMG4 | URG | epidermal growth factor (beta-urogastrone) | - | HPRD,BioGRID | 12093292 |
| EGFR | ERBB | ERBB1 | HER1 | PIG61 | mENA | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | - | HPRD | 11500850 |
| EGFR | ERBB | ERBB1 | HER1 | PIG61 | mENA | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | EGFR interacts with ErbB2. | BIND | 15652750 |
| ERBB2 | CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | Affinity Capture-Western | BioGRID | 14576349 |
| ERBB2IP | ERBIN | LAP2 | erbb2 interacting protein | - | HPRD,BioGRID | 10878805 |11278603 |
| ERBB3 | ErbB-3 | HER3 | LCCS2 | MDA-BF-1 | MGC88033 | c-erbB-3 | c-erbB3 | erbB3-S | p180-ErbB3 | p45-sErbB3 | p85-sErbB3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | - | HPRD | 7538656 |10799311 |
| ERBB3 | ErbB-3 | HER3 | LCCS2 | MDA-BF-1 | MGC88033 | c-erbB-3 | c-erbB3 | erbB3-S | p180-ErbB3 | p45-sErbB3 | p85-sErbB3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | - | HPRD | 7538656 |
| ERBB4 | HER4 | MGC138404 | p180erbB4 | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) | Affinity Capture-Western | BioGRID | 10839362 |
| ERRFI1 | GENE-33 | MIG-6 | MIG6 | RALT | ERBB receptor feedback inhibitor 1 | RALT interacts with an unspecified isoform of ERBB2. This interaction was modeled on a demonstrated interaction between RALT from an unspecified species and human ERBB2. | BIND | 15856022 |
| GRB2 | ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 | growth factor receptor-bound protein 2 | - | HPRD | 11173924 |11606575|11606575 |
| GRB2 | ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 | growth factor receptor-bound protein 2 | - | HPRD,BioGRID | 11606575 |
| GRB7 | - | growth factor receptor-bound protein 7 | - | HPRD,BioGRID | 9079677 |
| H3F3A | H3.3A | H3F3 | MGC87782 | MGC87783 | H3 histone, family 3A | Histone H3 interacts with erbB2 promoter. | BIND | 15311210 |
| HLA-A | HLAA | major histocompatibility complex, class I, A | - | HPRD,BioGRID | 10593938 |
| HSP90AA1 | FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | ERBB2 interacts with HSP90. This interaction was modelled on a demonstrated interaction between human ERBB2 and monkey HSP90. | BIND | 15643424 |
| HSP90AA1 | FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | - | HPRD,BioGRID | 11071886 |
| HSP90B1 | ECGP | GP96 | GRP94 | TRA1 | heat shock protein 90kDa beta (Grp94), member 1 | - | HPRD,BioGRID | 8617772 |
| IL6ST | CD130 | CDw130 | GP130 | GP130-RAPS | IL6R-beta | interleukin 6 signal transducer (gp130, oncostatin M receptor) | - | HPRD,BioGRID | 11821958 |
| ITGB4 | CD104 | integrin, beta 4 | - | HPRD | 11375975 |
| JAK2 | JTK10 | Janus kinase 2 (a protein tyrosine kinase) | - | HPRD,BioGRID | 11940572 |
| JUP | ARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGB | junction plakoglobin | - | HPRD,BioGRID | 7702605 |
| MATK | CHK | CTK | DKFZp434N1212 | HHYLTK | HYL | HYLTK | Lsk | MGC1708 | MGC2101 | megakaryocyte-associated tyrosine kinase | - | HPRD | 12122014 |
| MMP16 | MMP-X2 | MT-MMP2 | MT-MMP3 | MT3-MMP | matrix metallopeptidase 16 (membrane-inserted) | ErbB-2 interacts with the MMP16 locus. | BIND | 15380516 |
| MUC1 | CD227 | EMA | H23AG | MAM6 | PEM | PEMT | PUM | mucin 1, cell surface associated | - | HPRD,BioGRID | 11278868 |
| MUC4 | HSA276359 | mucin 4, cell surface associated | - | HPRD | 11598901 |11687512 |12434309 |
| NCOA3 | ACTR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIP | nuclear receptor coactivator 3 | NCOA3 (AIB1) interacts with the ERBB2 (HER2) promoter. | BIND | 15788656 |
| NCOR1 | KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoR | nuclear receptor co-repressor 1 | NCOR1 (NCoR) interacts with the ERBB2 (HER2) promoter. | BIND | 15788656 |
| NF2 | ACN | BANF | SCH | neurofibromin 2 (merlin) | - | HPRD | 12118253 |
| NRG1 | ARIA | GGF | GGF2 | HGL | HRG | HRG1 | HRGA | NDF | SMDF | neuregulin 1 | Reconstituted Complex | BioGRID | 7592681 |
| NRG1 | ARIA | GGF | GGF2 | HGL | HRG | HRG1 | HRGA | NDF | SMDF | neuregulin 1 | - | HPRD | 9168114 |
| OSMR | MGC150626 | MGC150627 | MGC75127 | OSMRB | oncostatin M receptor | Affinity Capture-Western | BioGRID | 11821958 |
| PAK1 | MGC130000 | MGC130001 | PAKalpha | p21 protein (Cdc42/Rac)-activated kinase 1 | - | HPRD,BioGRID | 9774445 |
| PICK1 | MGC15204 | PICK | PRKCABP | protein interacting with PRKCA 1 | - | HPRD,BioGRID | 11278603 |
| PIK3R1 | GRB1 | p85 | p85-ALPHA | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | - | HPRD | 1351056 |
| PIK3R2 | P85B | p85 | p85-BETA | phosphoinositide-3-kinase, regulatory subunit 2 (beta) | - | HPRD,BioGRID | 1334406 |
| PLCG1 | PLC-II | PLC1 | PLC148 | PLCgamma1 | phospholipase C, gamma 1 | - | HPRD,BioGRID | 1676673 |1683701 |
| PTK2 | FADK | FAK | FAK1 | pp125FAK | PTK2 protein tyrosine kinase 2 | - | HPRD | 11807823 |
| PTK2B | CADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTK | PTK2B protein tyrosine kinase 2 beta | - | HPRD,BioGRID | 10713673 |
| PTPN11 | BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2 | protein tyrosine phosphatase, non-receptor type 11 | Affinity Capture-MS | BioGRID | 16729043 |
| SERPINA3 | AACT | ACT | GIG24 | GIG25 | MGC88254 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | - | HPRD | 10829039 |
| SH3BGRL | MGC117402 | SH3BGR | SH3 domain binding glutamic acid-rich protein like | Affinity Capture-MS | BioGRID | 16729043 |
| SHC1 | FLJ26504 | SHC | SHCA | SHC (Src homology 2 domain containing) transforming protein 1 | - | HPRD,BioGRID | 9710588 |
| SOS1 | GF1 | GGF1 | GINGF | HGF | NS4 | son of sevenless homolog 1 (Drosophila) | - | HPRD | 11173924 |
| SRC | ASV | SRC1 | c-SRC | p60-Src | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | - | HPRD | 7542762 |
| SRC | ASV | SRC1 | c-SRC | p60-Src | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | Reconstituted Complex | BioGRID | 11940572 |
| SRC | ASV | SRC1 | c-SRC | p60-Src | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | SRC (SRC-1) interacts with the ERBB2 (HER2) promoter. | BIND | 15788656 |
| STAT3 | APRF | FLJ20882 | HIES | MGC16063 | signal transducer and activator of transcription 3 (acute-phase response factor) | Affinity Capture-Western | BioGRID | 11940572 |
| TOB1 | APRO6 | MGC104792 | MGC34446 | PIG49 | TOB | TROB | TROB1 | transducer of ERBB2, 1 | - | HPRD | 8632892 |
| TP53RK | BUD32 | C20orf64 | Nori-2 | Nori-2p | PRPK | dJ101A2 | TP53 regulating kinase | ErbB-2 interacts with the PRPK promoter. | BIND | 15380516 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG ERBB SIGNALING PATHWAY | 87 | 71 | All SZGR 2.0 genes in this pathway |
| KEGG CALCIUM SIGNALING PATHWAY | 178 | 134 | All SZGR 2.0 genes in this pathway |
| KEGG FOCAL ADHESION | 201 | 138 | All SZGR 2.0 genes in this pathway |
| KEGG ADHERENS JUNCTION | 75 | 53 | All SZGR 2.0 genes in this pathway |
| KEGG PATHWAYS IN CANCER | 328 | 259 | All SZGR 2.0 genes in this pathway |
| KEGG PANCREATIC CANCER | 70 | 56 | All SZGR 2.0 genes in this pathway |
| KEGG ENDOMETRIAL CANCER | 52 | 45 | All SZGR 2.0 genes in this pathway |
| KEGG PROSTATE CANCER | 89 | 75 | All SZGR 2.0 genes in this pathway |
| KEGG BLADDER CANCER | 42 | 33 | All SZGR 2.0 genes in this pathway |
| KEGG NON SMALL CELL LUNG CANCER | 54 | 47 | All SZGR 2.0 genes in this pathway |
| PID ERBB4 PATHWAY | 38 | 32 | All SZGR 2.0 genes in this pathway |
| PID ERBB2 ERBB3 PATHWAY | 44 | 35 | All SZGR 2.0 genes in this pathway |
| PID ERBB NETWORK PATHWAY | 15 | 13 | All SZGR 2.0 genes in this pathway |
| PID A6B1 A6B4 INTEGRIN PATHWAY | 46 | 35 | All SZGR 2.0 genes in this pathway |
| PID MYC REPRESS PATHWAY | 63 | 52 | All SZGR 2.0 genes in this pathway |
| REACTOME DEVELOPMENTAL BIOLOGY | 396 | 292 | All SZGR 2.0 genes in this pathway |
| REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | 12 | 9 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY ERBB2 | 101 | 78 | All SZGR 2.0 genes in this pathway |
| REACTOME GRB2 EVENTS IN ERBB2 SIGNALING | 22 | 20 | All SZGR 2.0 genes in this pathway |
| REACTOME PI3K EVENTS IN ERBB2 SIGNALING | 44 | 34 | All SZGR 2.0 genes in this pathway |
| REACTOME AXON GUIDANCE | 251 | 188 | All SZGR 2.0 genes in this pathway |
| REACTOME SEMA4D IN SEMAPHORIN SIGNALING | 32 | 22 | All SZGR 2.0 genes in this pathway |
| REACTOME SEMAPHORIN INTERACTIONS | 68 | 53 | All SZGR 2.0 genes in this pathway |
| REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | 27 | 21 | All SZGR 2.0 genes in this pathway |
| DAVICIONI MOLECULAR ARMS VS ERMS DN | 182 | 111 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP | 450 | 256 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN | 805 | 505 | All SZGR 2.0 genes in this pathway |
| KOKKINAKIS METHIONINE DEPRIVATION 48HR UP | 128 | 95 | All SZGR 2.0 genes in this pathway |
| KOKKINAKIS METHIONINE DEPRIVATION 96HR UP | 117 | 84 | All SZGR 2.0 genes in this pathway |
| LINDGREN BLADDER CANCER CLUSTER 1 DN | 378 | 231 | All SZGR 2.0 genes in this pathway |
| LINDGREN BLADDER CANCER CLUSTER 3 UP | 329 | 196 | All SZGR 2.0 genes in this pathway |
| CHIN BREAST CANCER COPY NUMBER UP | 27 | 18 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN | 770 | 415 | All SZGR 2.0 genes in this pathway |
| BARIS THYROID CANCER DN | 59 | 45 | All SZGR 2.0 genes in this pathway |
| HAMAI APOPTOSIS VIA TRAIL DN | 186 | 107 | All SZGR 2.0 genes in this pathway |
| DACOSTA UV RESPONSE VIA ERCC3 TTD UP | 64 | 39 | All SZGR 2.0 genes in this pathway |
| BREUHAHN GROWTH FACTOR SIGNALING IN LIVER CANCER | 22 | 19 | All SZGR 2.0 genes in this pathway |
| LI AMPLIFIED IN LUNG CANCER | 178 | 108 | All SZGR 2.0 genes in this pathway |
| MYLLYKANGAS AMPLIFICATION HOT SPOT 12 | 11 | 8 | All SZGR 2.0 genes in this pathway |
| FARMER BREAST CANCER CLUSTER 8 | 7 | 7 | All SZGR 2.0 genes in this pathway |
| DACOSTA UV RESPONSE VIA ERCC3 UP | 309 | 199 | All SZGR 2.0 genes in this pathway |
| LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL DN | 114 | 58 | All SZGR 2.0 genes in this pathway |
| LI WILMS TUMOR VS FETAL KIDNEY 2 DN | 51 | 42 | All SZGR 2.0 genes in this pathway |
| BERTUCCI INVASIVE CARCINOMA DUCTAL VS LOBULAR UP | 25 | 17 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES 1 | 379 | 235 | All SZGR 2.0 genes in this pathway |
| BENPORATH NANOG TARGETS | 988 | 594 | All SZGR 2.0 genes in this pathway |
| BENPORATH SOX2 TARGETS | 734 | 436 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 17Q11 Q21 AMPLICON | 133 | 78 | All SZGR 2.0 genes in this pathway |
| FRASOR RESPONSE TO ESTRADIOL DN | 82 | 52 | All SZGR 2.0 genes in this pathway |
| WEIGEL OXIDATIVE STRESS BY HNE AND H2O2 | 39 | 29 | All SZGR 2.0 genes in this pathway |
| KAAB HEART ATRIUM VS VENTRICLE UP | 249 | 170 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 14HR DN | 298 | 200 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
| HEDENFALK BREAST CANCER BRCA1 VS BRCA2 | 163 | 113 | All SZGR 2.0 genes in this pathway |
| DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN | 287 | 208 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 | 482 | 296 | All SZGR 2.0 genes in this pathway |
| HILLION HMGA1 TARGETS | 90 | 71 | All SZGR 2.0 genes in this pathway |
| HILLION HMGA1B TARGETS | 92 | 68 | All SZGR 2.0 genes in this pathway |
| KYNG DNA DAMAGE BY GAMMA RADIATION | 81 | 59 | All SZGR 2.0 genes in this pathway |
| KYNG DNA DAMAGE UP | 226 | 164 | All SZGR 2.0 genes in this pathway |
| MASSARWEH TAMOXIFEN RESISTANCE UP | 578 | 341 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER ERBB2 UP | 147 | 83 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER BASAL DN | 701 | 446 | All SZGR 2.0 genes in this pathway |
| CLIMENT BREAST CANCER COPY NUMBER UP | 23 | 20 | All SZGR 2.0 genes in this pathway |
| GRESHOCK CANCER COPY NUMBER UP | 323 | 240 | All SZGR 2.0 genes in this pathway |
| VART KSHV INFECTION ANGIOGENIC MARKERS UP | 165 | 118 | All SZGR 2.0 genes in this pathway |
| VART KSHV INFECTION ANGIOGENIC MARKERS DN | 138 | 92 | All SZGR 2.0 genes in this pathway |
| MOOTHA MITOCHONDRIA | 447 | 277 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| SHEDDEN LUNG CANCER GOOD SURVIVAL A4 | 196 | 124 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS UP | 395 | 249 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 | 1069 | 729 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA HAPTOTAXIS DN | 668 | 419 | All SZGR 2.0 genes in this pathway |
| TCGA GLIOBLASTOMA MUTATED | 8 | 8 | All SZGR 2.0 genes in this pathway |
| DANG REGULATED BY MYC DN | 253 | 192 | All SZGR 2.0 genes in this pathway |
| DANG MYC TARGETS DN | 31 | 25 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| CHANDRAN METASTASIS DN | 306 | 191 | All SZGR 2.0 genes in this pathway |
| DUTERTRE ESTRADIOL RESPONSE 6HR DN | 91 | 56 | All SZGR 2.0 genes in this pathway |
| DUTERTRE ESTRADIOL RESPONSE 24HR DN | 505 | 328 | All SZGR 2.0 genes in this pathway |
| PEDRIOLI MIR31 TARGETS UP | 221 | 120 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY STEM CELL DN | 428 | 246 | All SZGR 2.0 genes in this pathway |