Gene Page: F7

Summary ?
GeneID2155
SymbolF7
SynonymsSPCA
Descriptioncoagulation factor VII
ReferenceMIM:613878|HGNC:HGNC:3544|Ensembl:ENSG00000057593|HPRD:01965|Vega:OTTHUMG00000017373
Gene typeprotein-coding
Map location13q34
Pascal p-value0.273
Fetal beta-1.135
DMG1 (# studies)
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Frontal Cortex BA9
Nucleus accumbens basal ganglia
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg0333875413113765397F72.574E-40.4450.038DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10994209chr1061877705F721550.16trans
rs20030183413113759753F7ENSG00000057593.99.20784E-70.02-352gtex_brain_ba24
rs277403313113765235F7ENSG00000057593.98.73488E-70.025130gtex_brain_ba24
rs49109813113769346F7ENSG00000057593.99.71241E-70.029241gtex_brain_ba24
rs49383313113769639F7ENSG00000057593.99.41633E-70.029534gtex_brain_ba24
rs56955713113769917F7ENSG00000057593.98.96006E-70.029812gtex_brain_ba24
rs604213113770068F7ENSG00000057593.99.08646E-70.029963gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GNG30.780.83
STX1A0.770.85
CAMK10.750.82
NPM20.750.84
PNOC0.740.82
LEPREL20.740.85
TCEAL10.740.82
PRKCZ0.730.81
STK32C0.730.83
SNCA0.720.78
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PLXNB1-0.42-0.42
PXN-0.41-0.42
RAB13-0.40-0.49
GPR125-0.40-0.39
REST-0.39-0.37
CASKIN2-0.39-0.40
GRTP1-0.38-0.40
EPHA2-0.38-0.41
SORBS3-0.37-0.39
TP53BP2-0.37-0.33

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityIEAglutamate (GO term level: 7)-
GO:0004252serine-type endopeptidase activityTASglutamate (GO term level: 7)3037537 
GO:0003824catalytic activityIEA-
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIPI18267072 
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisIEA-
GO:0007598blood coagulation, extrinsic pathwayEXP7598447 
GO:0007596blood coagulationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP3527261 |8598903 |8639673 
GO:0005576extracellular regionIEA-
GO:0005576extracellular regionTAS3037537 
GO:0005886plasma membraneEXP2271516 |3527261 |8598903 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG COMPLEMENT AND COAGULATION CASCADES 6949All SZGR 2.0 genes in this pathway
BIOCARTA AMI PATHWAY 2013All SZGR 2.0 genes in this pathway
BIOCARTA EXTRINSIC PATHWAY 139All SZGR 2.0 genes in this pathway
REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 2717All SZGR 2.0 genes in this pathway
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION 3627All SZGR 2.0 genes in this pathway
REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS 118All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518242All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE 3222All SZGR 2.0 genes in this pathway
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION 188116All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN CLOCK 5340All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP 380215All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233161All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5 14789All SZGR 2.0 genes in this pathway
XU HGF TARGETS INDUCED BY AKT1 48HR DN 2717All SZGR 2.0 genes in this pathway
LIU COMMON CANCER GENES 7947All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO DN 200112All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412249All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR DN 9164All SZGR 2.0 genes in this pathway
ZHU CMV ALL DN 12893All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC UP 202115All SZGR 2.0 genes in this pathway
STEARMAN TUMOR FIELD EFFECT UP 3622All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE DN 6139All SZGR 2.0 genes in this pathway
COATES MACROPHAGE M1 VS M2 DN 7844All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS UP 170107All SZGR 2.0 genes in this pathway
CHENG IMPRINTED BY ESTRADIOL 11068All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425261All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS DN 13892All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491316All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 DN 5132All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
VANLOO SP3 TARGETS DN 8947All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467251All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238125All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway