Gene Page: FABP6

Summary ?
GeneID2172
SymbolFABP6
SynonymsI-15P|I-BABP|I-BALB|I-BAP|ILBP|ILBP3|ILLBP
Descriptionfatty acid binding protein 6
ReferenceMIM:600422|HGNC:HGNC:3561|Ensembl:ENSG00000170231|HPRD:02689|Vega:OTTHUMG00000130329
Gene typeprotein-coding
Map location5q33.3-q34
Pascal p-value0.221
Sherlock p-value0.026
Fetal beta-0.903
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.0032 
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.01718 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00459 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs962101chr5160353230FABP621720.04cis

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SMC40.820.59
SGOL20.820.63
C14orf1060.820.65
RTKN20.820.56
KIF110.820.63
SMC20.820.70
ECT20.820.62
ATAD20.820.62
BRIP10.820.60
MCM80.810.69
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CXCL14-0.41-0.60
IFI27-0.41-0.59
PTH1R-0.41-0.54
CST3-0.41-0.59
MT-CO2-0.40-0.55
AF347015.31-0.40-0.54
AC011427.1-0.39-0.51
AIFM3-0.38-0.50
MT-CYB-0.38-0.53
FXYD1-0.38-0.55

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005215transporter activityIEA-
GO:0008289lipid bindingIEA-
GO:0008289lipid bindingTAS7588781 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008285negative regulation of cell proliferationTAS9250612 
GO:0006810transportIEA-
GO:0006629lipid metabolic processNAS9250612 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmTAS7588781 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PPAR SIGNALING PATHWAY 6947All SZGR 2.0 genes in this pathway
REACTOME BILE ACID AND BILE SALT METABOLISM 2711All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA UP 14175All SZGR 2.0 genes in this pathway
LIU CDX2 TARGETS UP 3622All SZGR 2.0 genes in this pathway
NAKAMURA LUNG CANCER DIFFERENTIATION MARKERS 145All SZGR 2.0 genes in this pathway
KOBAYASHI RESPONSE TO ROMIDEPSIN 1914All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER A 10063All SZGR 2.0 genes in this pathway
YOKOE CANCER TESTIS ANTIGENS 3822All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264159All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA VIA KDM3A 5334All SZGR 2.0 genes in this pathway