Gene Page: FCER1A

Summary ?
GeneID2205
SymbolFCER1A
SynonymsFCE1A|FcERI
DescriptionFc fragment of IgE receptor Ia
ReferenceMIM:147140|HGNC:HGNC:3609|Ensembl:ENSG00000179639|HPRD:00917|Vega:OTTHUMG00000037176
Gene typeprotein-coding
Map location1q23
eGeneMeta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
CV:PheWASPhenome-wide association studies (PheWAS)157 SNPs associated with schizophrenia 1
GSMA_IGenome scan meta-analysisPsr: 0.0235 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00814 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@CV:PheWAS

SNP IDChromosomePositionAllelePFunctionGeneUp/Down Distance
rs22517461159272060null0.5424FCER1Anull


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0019767IgE receptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001820serotonin secretionIEAneuron, serotonin (GO term level: 7)-
GO:0001812positive regulation of type I hypersensitivityIEA-
GO:0007257activation of JNK activityIEA-
GO:0007166cell surface receptor linked signal transductionIEA-
GO:0019370leukotriene biosynthetic processIEA-
GO:0043306positive regulation of mast cell degranulationIEA-
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIEA-
GO:0050850positive regulation of calcium-mediated signalingIEA-
GO:0045401positive regulation of interleukin-3 biosynthetic processIEA-
GO:0045425positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0009897external side of plasma membraneIEA-
GO:0005886plasma membraneTAS1535625 
GO:0005887integral to plasma membraneIEA-
GO:0005887integral to plasma membraneTAS2964640 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG FC EPSILON RI SIGNALING PATHWAY 7958All SZGR 2.0 genes in this pathway
KEGG ASTHMA 3025All SZGR 2.0 genes in this pathway
BIOCARTA FCER1 PATHWAY 4130All SZGR 2.0 genes in this pathway
PID FCER1 PATHWAY 6243All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN 258141All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN 14290All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 DN 242165All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINED IN GRANULOCYTE DN 76All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN 187115All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION GRANULOCYTE DN 1713All SZGR 2.0 genes in this pathway
KIM MYCN AMPLIFICATION TARGETS UP 9264All SZGR 2.0 genes in this pathway
LIANG HEMATOPOIESIS STEM CELL NUMBER LARGE VS TINY UP 4424All SZGR 2.0 genes in this pathway
LIANG HEMATOPOIESIS STEM CELL NUMBER SMALL VS HUGE UP 3829All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT DN 12986All SZGR 2.0 genes in this pathway
NAKAJIMA MAST CELL 4634All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246180All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405264All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN 564326All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338225All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN 235144All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245150All SZGR 2.0 genes in this pathway
LIANG HEMATOPOIESIS STEM CELL NUMBER QTL 1710All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN 213127All SZGR 2.0 genes in this pathway
ZWANG DOWN BY 2ND EGF PULSE 293119All SZGR 2.0 genes in this pathway
HECKER IFNB1 TARGETS 9554All SZGR 2.0 genes in this pathway