Gene Page: AK9
Summary ?
| GeneID | 221264 |
| Symbol | AK9 |
| Synonyms | AK 9|AKD1|AKD2|C6orf199|C6orf224|dJ70A9.1 |
| Description | adenylate kinase 9 |
| Reference | MIM:615358|HGNC:HGNC:33814|Ensembl:ENSG00000155085|HPRD:12871|Vega:OTTHUMG00000157658 |
| Gene type | protein-coding |
| Map location | 6q21 |
| Pascal p-value | 0.882 |
| DMG | 1 (# studies) |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Nucleus accumbens basal ganglia Putamen basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg00930347 | 6 | 110012366 | AK9 | 1.82E-8 | -0.006 | 6.53E-6 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs6911838 | 6 | 109799923 | AK9 | ENSG00000155085.11 | 1.688E-6 | 0.01 | 212497 | gtex_brain_ba24 |
| rs1998811 | 6 | 109812138 | AK9 | ENSG00000155085.11 | 4.608E-6 | 0.01 | 200282 | gtex_brain_ba24 |
| rs12195904 | 6 | 109815963 | AK9 | ENSG00000155085.11 | 3.132E-6 | 0.01 | 196457 | gtex_brain_ba24 |
| rs12197180 | 6 | 109821890 | AK9 | ENSG00000155085.11 | 4.604E-6 | 0.01 | 190530 | gtex_brain_ba24 |
| rs3056655 | 6 | 109824194 | AK9 | ENSG00000155085.11 | 2.921E-6 | 0.01 | 188226 | gtex_brain_ba24 |
| rs200786999 | 6 | 109870861 | AK9 | ENSG00000155085.11 | 3.112E-6 | 0.01 | 141559 | gtex_brain_ba24 |
| rs13201430 | 6 | 109956050 | AK9 | ENSG00000155085.11 | 1.009E-6 | 0.01 | 56370 | gtex_brain_ba24 |
| rs12205140 | 6 | 109966820 | AK9 | ENSG00000155085.11 | 4.504E-6 | 0.01 | 45600 | gtex_brain_ba24 |
| rs13199109 | 6 | 109973505 | AK9 | ENSG00000155085.11 | 3.232E-6 | 0.01 | 38915 | gtex_brain_ba24 |
| rs11153213 | 6 | 110015093 | AK9 | ENSG00000155085.11 | 6.593E-7 | 0.01 | -2673 | gtex_brain_ba24 |
| rs11153214 | 6 | 110015323 | AK9 | ENSG00000155085.11 | 3.393E-6 | 0.01 | -2903 | gtex_brain_ba24 |
| rs12201356 | 6 | 110015875 | AK9 | ENSG00000155085.11 | 1.363E-6 | 0.01 | -3455 | gtex_brain_ba24 |
| rs3799845 | 6 | 110027717 | AK9 | ENSG00000155085.11 | 1.364E-6 | 0.01 | -15297 | gtex_brain_ba24 |
| rs2025148 | 6 | 110027943 | AK9 | ENSG00000155085.11 | 1.364E-6 | 0.01 | -15523 | gtex_brain_ba24 |
| rs12204548 | 6 | 110036707 | AK9 | ENSG00000155085.11 | 1.36E-6 | 0.01 | -24287 | gtex_brain_ba24 |
| rs3799849 | 6 | 110036763 | AK9 | ENSG00000155085.11 | 1.36E-6 | 0.01 | -24343 | gtex_brain_ba24 |
| rs398085217 | 6 | 110043938 | AK9 | ENSG00000155085.11 | 1.391E-6 | 0.01 | -31518 | gtex_brain_ba24 |
| rs12215077 | 6 | 110052880 | AK9 | ENSG00000155085.11 | 1.363E-6 | 0.01 | -40460 | gtex_brain_ba24 |
| rs11153215 | 6 | 110053721 | AK9 | ENSG00000155085.11 | 1.363E-6 | 0.01 | -41301 | gtex_brain_ba24 |
| rs2273752 | 6 | 110059510 | AK9 | ENSG00000155085.11 | 1.363E-6 | 0.01 | -47090 | gtex_brain_ba24 |
| rs12201444 | 6 | 110059954 | AK9 | ENSG00000155085.11 | 1.363E-6 | 0.01 | -47534 | gtex_brain_ba24 |
| rs4141930 | 6 | 110060818 | AK9 | ENSG00000155085.11 | 1.363E-6 | 0.01 | -48398 | gtex_brain_ba24 |
| rs4947016 | 6 | 110062098 | AK9 | ENSG00000155085.11 | 1.363E-6 | 0.01 | -49678 | gtex_brain_ba24 |
| rs1322124 | 6 | 110062873 | AK9 | ENSG00000155085.11 | 1.363E-6 | 0.01 | -50453 | gtex_brain_ba24 |
| rs9487064 | 6 | 109667763 | AK9 | ENSG00000155085.11 | 1.581E-6 | 0.01 | 344657 | gtex_brain_putamen_basal |
| rs9487066 | 6 | 109668910 | AK9 | ENSG00000155085.11 | 2.253E-6 | 0.01 | 343510 | gtex_brain_putamen_basal |
| rs4946967 | 6 | 109678572 | AK9 | ENSG00000155085.11 | 9.552E-7 | 0.01 | 333848 | gtex_brain_putamen_basal |
| rs9487069 | 6 | 109679855 | AK9 | ENSG00000155085.11 | 9.573E-7 | 0.01 | 332565 | gtex_brain_putamen_basal |
| rs699700 | 6 | 109688731 | AK9 | ENSG00000155085.11 | 9.573E-7 | 0.01 | 323689 | gtex_brain_putamen_basal |
| rs11251 | 6 | 109689907 | AK9 | ENSG00000155085.11 | 2.441E-7 | 0.01 | 322513 | gtex_brain_putamen_basal |
| rs3778474 | 6 | 109695985 | AK9 | ENSG00000155085.11 | 3.661E-7 | 0.01 | 316435 | gtex_brain_putamen_basal |
| rs13219952 | 6 | 109712287 | AK9 | ENSG00000155085.11 | 2.893E-6 | 0.01 | 300133 | gtex_brain_putamen_basal |
| rs7748669 | 6 | 109745342 | AK9 | ENSG00000155085.11 | 9.339E-7 | 0.01 | 267078 | gtex_brain_putamen_basal |
| rs6911838 | 6 | 109799923 | AK9 | ENSG00000155085.11 | 9.115E-7 | 0.01 | 212497 | gtex_brain_putamen_basal |
| rs1998811 | 6 | 109812138 | AK9 | ENSG00000155085.11 | 1.381E-6 | 0.01 | 200282 | gtex_brain_putamen_basal |
| rs7755941 | 6 | 109815351 | AK9 | ENSG00000155085.11 | 4.072E-7 | 0.01 | 197069 | gtex_brain_putamen_basal |
| rs12195904 | 6 | 109815963 | AK9 | ENSG00000155085.11 | 6.045E-7 | 0.01 | 196457 | gtex_brain_putamen_basal |
| rs1406899 | 6 | 109816305 | AK9 | ENSG00000155085.11 | 4.072E-7 | 0.01 | 196115 | gtex_brain_putamen_basal |
| rs11754455 | 6 | 109817883 | AK9 | ENSG00000155085.11 | 4.072E-7 | 0.01 | 194537 | gtex_brain_putamen_basal |
| rs2024849 | 6 | 109818291 | AK9 | ENSG00000155085.11 | 4.072E-7 | 0.01 | 194129 | gtex_brain_putamen_basal |
| rs2024850 | 6 | 109818456 | AK9 | ENSG00000155085.11 | 4.072E-7 | 0.01 | 193964 | gtex_brain_putamen_basal |
| rs2024853 | 6 | 109819954 | AK9 | ENSG00000155085.11 | 4.072E-7 | 0.01 | 192466 | gtex_brain_putamen_basal |
| rs12197180 | 6 | 109821890 | AK9 | ENSG00000155085.11 | 3.85E-7 | 0.01 | 190530 | gtex_brain_putamen_basal |
| rs12199154 | 6 | 109822996 | AK9 | ENSG00000155085.11 | 4.072E-7 | 0.01 | 189424 | gtex_brain_putamen_basal |
| rs2277114 | 6 | 109827716 | AK9 | ENSG00000155085.11 | 4.072E-7 | 0.01 | 184704 | gtex_brain_putamen_basal |
| rs10457193 | 6 | 109828567 | AK9 | ENSG00000155085.11 | 4.072E-7 | 0.01 | 183853 | gtex_brain_putamen_basal |
| rs10457194 | 6 | 109828569 | AK9 | ENSG00000155085.11 | 4.072E-7 | 0.01 | 183851 | gtex_brain_putamen_basal |
| rs71770197 | 6 | 109906329 | AK9 | ENSG00000155085.11 | 1.291E-6 | 0.01 | 106091 | gtex_brain_putamen_basal |
| rs13201430 | 6 | 109956050 | AK9 | ENSG00000155085.11 | 2.964E-7 | 0.01 | 56370 | gtex_brain_putamen_basal |
| rs79061475 | 6 | 109992939 | AK9 | ENSG00000155085.11 | 1.321E-6 | 0.01 | 19481 | gtex_brain_putamen_basal |
| rs7341297 | 6 | 110000682 | AK9 | ENSG00000155085.11 | 1.435E-6 | 0.01 | 11738 | gtex_brain_putamen_basal |
| rs11153213 | 6 | 110015093 | AK9 | ENSG00000155085.11 | 1.077E-6 | 0.01 | -2673 | gtex_brain_putamen_basal |
| rs12201356 | 6 | 110015875 | AK9 | ENSG00000155085.11 | 1.077E-6 | 0.01 | -3455 | gtex_brain_putamen_basal |
| rs3799845 | 6 | 110027717 | AK9 | ENSG00000155085.11 | 1.076E-6 | 0.01 | -15297 | gtex_brain_putamen_basal |
| rs2025148 | 6 | 110027943 | AK9 | ENSG00000155085.11 | 1.076E-6 | 0.01 | -15523 | gtex_brain_putamen_basal |
| rs12204548 | 6 | 110036707 | AK9 | ENSG00000155085.11 | 1.074E-6 | 0.01 | -24287 | gtex_brain_putamen_basal |
| rs3799849 | 6 | 110036763 | AK9 | ENSG00000155085.11 | 1.074E-6 | 0.01 | -24343 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.