Summary ?
GeneID2247
SymbolFGF2
SynonymsBFGF|FGF-2|FGFB|HBGF-2
Descriptionfibroblast growth factor 2
ReferenceMIM:134920|HGNC:HGNC:3676|Ensembl:ENSG00000138685|HPRD:00622|Vega:OTTHUMG00000039506
Gene typeprotein-coding
Map location4q26
Pascal p-value0.114
Fetal beta-1.074
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg126321524123748753FGF26.42E-9-0.0193.35E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10409262chr1958154954FGF222470.19trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GLUD10.910.88
SLC4A40.900.87
HTRA10.890.90
NT5E0.890.90
ATP13A40.890.89
ATP1A20.880.86
SUCLG20.870.84
SLC1A30.870.79
ADHFE10.870.90
MERTK0.860.89
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
DUSP12-0.58-0.68
MED19-0.58-0.67
ZNF821-0.58-0.67
BZW2-0.58-0.71
MLLT11-0.57-0.65
MPP3-0.57-0.67
RTF1-0.57-0.68
USF1-0.57-0.67
SPATS2-0.57-0.66
ZBTB8A-0.56-0.64

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI11075807 
GO:0008201heparin bindingIEA-
GO:0008083growth factor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0010001glial cell differentiationIEAGlial (GO term level: 8)-
GO:0007399nervous system developmentTASneurite (GO term level: 5)9576942 
GO:0000186activation of MAPKK activityIEA-
GO:0000187activation of MAPK activityTAS9712850 
GO:0001759induction of an organIEA-
GO:0001934positive regulation of protein amino acid phosphorylationIEA-
GO:0007265Ras protein signal transductionTAS10848592 
GO:0009887organ morphogenesisTAS10903182 
GO:0007165signal transductionNAS9712850 
GO:0008285negative regulation of cell proliferationIEA-
GO:0008543fibroblast growth factor receptor signaling pathwayEXP17133345 
GO:0006935chemotaxisTAS10848592 
GO:0007275multicellular organismal developmentIEA-
GO:0021940positive regulation of granule cell precursor proliferationIEA-
GO:0030324lung developmentIEA-
GO:0045766positive regulation of angiogenesisIEA-
GO:0050679positive regulation of epithelial cell proliferationIEA-
GO:0045597positive regulation of cell differentiationIEA-
GO:0046668regulation of retinal cell programmed cell deathIEA-
GO:0060045positive regulation of cardiac muscle cell proliferationIDA9553078 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP1697263 |8622701 |9139660 
|11294897 |16597617 
GO:0005576extracellular regionTAS10490103 
GO:0005615extracellular spaceTAS2435575 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
API5AAC-11 | AAC11 | API5L1apoptosis inhibitor 5-HPRD11075807 
CD44CDW44 | CSPG8 | ECMR-III | HCELL | IN | LHR | MC56 | MDU2 | MDU3 | MGC10468 | MIC4 | MUTCH-I | Pgp1CD44 molecule (Indian blood group)-HPRD7532176 
CEP57KIAA0092 | PIG8 | TSP57centrosomal protein 57kDa-HPRD12717444 
CSNK2A1CK2A1 | CKIIcasein kinase 2, alpha 1 polypeptide-HPRD,BioGRID12145206 
CSNK2A2CK2A2 | CSNK2A1 | FLJ43934casein kinase 2, alpha prime polypeptideReconstituted ComplexBioGRID12145206 
CSNK2A2CK2A2 | CSNK2A1 | FLJ43934casein kinase 2, alpha prime polypeptide-HPRD7735329 
CSNK2BCK2B | CK2N | CSK2B | G5A | MGC138222 | MGC138224casein kinase 2, beta polypeptideReconstituted ComplexBioGRID12145206 
CXCL13ANGIE | ANGIE2 | BCA-1 | BCA1 | BLC | BLR1L | SCYB13chemokine (C-X-C motif) ligand 13-HPRD11708770 
FGFBP1FGFBP | HBP17fibroblast growth factor binding protein 1-HPRD,BioGRID11509569 
FGFR1BFGFR | CD331 | CEK | FGFBR | FLG | FLJ99988 | FLT2 | HBGFR | KAL2 | N-SAMfibroblast growth factor receptor 1-HPRD,BioGRID10950949 |11030354 
FGFR2BEK | BFR-1 | CD332 | CEK3 | CFD1 | ECT1 | FLJ98662 | JWS | K-SAM | KGFR | TK14 | TK25fibroblast growth factor receptor 2-HPRD10950949 
FGFR4CD334 | JTK2 | MGC20292 | TKFfibroblast growth factor receptor 4-HPRD8530375 
GPC3DGSX | OCI-5 | SDYS | SGB | SGBS | SGBS1glypican 3-HPRD,BioGRID12478660 
GPC4K-glypicanglypican 4-HPRD,BioGRID11066092 
HSPG2PLC | PRCAN | SJA | SJS | SJS1heparan sulfate proteoglycan 2-HPRD11847221 
NRP1BDCA4 | CD304 | DKFZp686A03134 | DKFZp781F1414 | NP1 | NRP | VEGF165Rneuropilin 1NRP1 (Npn-1) interacts with FGF2. This interaction was modeled on a demonstrated interaction between rat NRP1 and human FGF2.BIND15695515 
PF4CXCL4 | MGC138298 | SCYB4platelet factor 4-HPRD9558385 
RPL6SHUJUN-2 | TAXREB107 | TXREB1ribosomal protein L6-HPRD,BioGRID9826564 
RPS19DBAribosomal protein S19-HPRD,BioGRID11716516 
SDC1CD138 | SDC | SYND1 | syndecansyndecan 1Co-purificationBioGRID16982797 
SDC2HSPG | HSPG1 | SYND2syndecan 2Co-purificationBioGRID16982797 
SDC3N-syndecan | SDCN | SYND3syndecan 3-HPRD,BioGRID8344959 
SDC4MGC22217 | SYND4syndecan 4Co-purificationBioGRID16982797 
VTNV75 | VN | VNTvitronectin-HPRD,BioGRID11796824 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG MAPK SIGNALING PATHWAY 267205All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216144All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG MELANOMA 7157All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY 5645All SZGR 2.0 genes in this pathway
PID GLYPICAN 1PATHWAY 2720All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY 5041All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY 7553All SZGR 2.0 genes in this pathway
PID SYNDECAN 4 PATHWAY 3225All SZGR 2.0 genes in this pathway
PID FGF PATHWAY 5537All SZGR 2.0 genes in this pathway
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING 3724All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE 8764All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE 12788All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED POINT MUTANTS OF FGFR2 1611All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR1 MUTANTS 3020All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 118All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR3 MUTANTS 119All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR MUTANTS 4429All SZGR 2.0 genes in this pathway
REACTOME FRS2 MEDIATED CASCADE 3627All SZGR 2.0 genes in this pathway
REACTOME PI 3K CASCADE 5639All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR 10074All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE 5440All SZGR 2.0 genes in this pathway
REACTOME SHC MEDIATED CASCADE 2819All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR 10872All SZGR 2.0 genes in this pathway
REACTOME FGFR LIGAND BINDING AND ACTIVATION 2215All SZGR 2.0 genes in this pathway
REACTOME FGFR2C LIGAND BINDING AND ACTIVATION 129All SZGR 2.0 genes in this pathway
REACTOME FGFR4 LIGAND BINDING AND ACTIVATION 128All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR 11280All SZGR 2.0 genes in this pathway
REACTOME FGFR1 LIGAND BINDING AND ACTIVATION 149All SZGR 2.0 genes in this pathway
REACTOME PI3K CASCADE 7151All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING DN 4629All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP 294178All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455304All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP 290177All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR DN 6439All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 11784All SZGR 2.0 genes in this pathway
STREICHER LSM1 TARGETS DN 1913All SZGR 2.0 genes in this pathway
BAKER HEMATOPOESIS STAT1 TARGETS 109All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855609All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483336All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE DN 9859All SZGR 2.0 genes in this pathway
WU CELL MIGRATION 184114All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379235All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS 290172All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
BENPORATH NOS TARGETS 179105All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 240 HELA 6043All SZGR 2.0 genes in this pathway
GEORGES CELL CYCLE MIR192 TARGETS 6246All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
STANELLE E2F1 TARGETS 2920All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS UP 14591All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT UP 8961All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408274All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314201All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR DN 8662All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371218All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298200All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH DN 5843All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR DN 10170All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262186All SZGR 2.0 genes in this pathway
MA PITUITARY FETAL VS ADULT UP 2921All SZGR 2.0 genes in this pathway
SATO SILENCED EPIGENETICALLY IN PANCREATIC CANCER 4930All SZGR 2.0 genes in this pathway
GEISS RESPONSE TO DSRNA UP 3829All SZGR 2.0 genes in this pathway
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN DN 5132All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR DN 160101All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO OR GAMMA RADIATION 1513All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195135All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP 180114All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING UP 11580All SZGR 2.0 genes in this pathway
BASSO HAIRY CELL LEUKEMIA DN 8066All SZGR 2.0 genes in this pathway
BONCI TARGETS OF MIR15A AND MIR16 1 9175All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS DN 13892All SZGR 2.0 genes in this pathway
JU AGING TERC TARGETS UP 106All SZGR 2.0 genes in this pathway
MIZUKAMI HYPOXIA UP 1212All SZGR 2.0 genes in this pathway
MIZUKAMI HYPOXIA DN 65All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS FIBROBLAST UP 8460All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER DN 13483All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491319All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA PR DN 4434All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR UP 199143All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR UP 16697All SZGR 2.0 genes in this pathway
GHANDHI DIRECT IRRADIATION UP 11068All SZGR 2.0 genes in this pathway
GHANDHI BYSTANDER IRRADIATION UP 8654All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344197All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/10756395645m8hsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-140377437801Ahsa-miR-140brainAGUGGUUUUACCCUAUGGUAG
miR-15/16/195/424/497564056471A,m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-503560056061Ahsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
hsa-miR-503UAGCAGCGGGAACAGUUCUGCAG