Gene Page: FGF2
Summary ?
GeneID | 2247 |
Symbol | FGF2 |
Synonyms | BFGF|FGF-2|FGFB|HBGF-2 |
Description | fibroblast growth factor 2 |
Reference | MIM:134920|HGNC:HGNC:3676|Ensembl:ENSG00000138685|HPRD:00622|Vega:OTTHUMG00000039506 |
Gene type | protein-coding |
Map location | 4q26 |
Pascal p-value | 0.114 |
Fetal beta | -1.074 |
DMG | 1 (# studies) |
eGene | Myers' cis & trans |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 2 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
---|---|---|---|---|---|---|---|
cg12632152 | 4 | 123748753 | FGF2 | 6.42E-9 | -0.019 | 3.35E-6 | DMG:Jaffe_2016 |
eQTL annotation
SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs10409262 | chr19 | 58154954 | FGF2 | 2247 | 0.19 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
GLUD1 | 0.91 | 0.88 |
SLC4A4 | 0.90 | 0.87 |
HTRA1 | 0.89 | 0.90 |
NT5E | 0.89 | 0.90 |
ATP13A4 | 0.89 | 0.89 |
ATP1A2 | 0.88 | 0.86 |
SUCLG2 | 0.87 | 0.84 |
SLC1A3 | 0.87 | 0.79 |
ADHFE1 | 0.87 | 0.90 |
MERTK | 0.86 | 0.89 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
DUSP12 | -0.58 | -0.68 |
MED19 | -0.58 | -0.67 |
ZNF821 | -0.58 | -0.67 |
BZW2 | -0.58 | -0.71 |
MLLT11 | -0.57 | -0.65 |
MPP3 | -0.57 | -0.67 |
RTF1 | -0.57 | -0.68 |
USF1 | -0.57 | -0.67 |
SPATS2 | -0.57 | -0.66 |
ZBTB8A | -0.56 | -0.64 |
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0005515 | protein binding | IPI | 11075807 | |
GO:0008201 | heparin binding | IEA | - | |
GO:0008083 | growth factor activity | IEA | - | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0010001 | glial cell differentiation | IEA | Glial (GO term level: 8) | - |
GO:0007399 | nervous system development | TAS | neurite (GO term level: 5) | 9576942 |
GO:0000186 | activation of MAPKK activity | IEA | - | |
GO:0000187 | activation of MAPK activity | TAS | 9712850 | |
GO:0001759 | induction of an organ | IEA | - | |
GO:0001934 | positive regulation of protein amino acid phosphorylation | IEA | - | |
GO:0007265 | Ras protein signal transduction | TAS | 10848592 | |
GO:0009887 | organ morphogenesis | TAS | 10903182 | |
GO:0007165 | signal transduction | NAS | 9712850 | |
GO:0008285 | negative regulation of cell proliferation | IEA | - | |
GO:0008543 | fibroblast growth factor receptor signaling pathway | EXP | 17133345 | |
GO:0006935 | chemotaxis | TAS | 10848592 | |
GO:0007275 | multicellular organismal development | IEA | - | |
GO:0021940 | positive regulation of granule cell precursor proliferation | IEA | - | |
GO:0030324 | lung development | IEA | - | |
GO:0045766 | positive regulation of angiogenesis | IEA | - | |
GO:0050679 | positive regulation of epithelial cell proliferation | IEA | - | |
GO:0045597 | positive regulation of cell differentiation | IEA | - | |
GO:0046668 | regulation of retinal cell programmed cell death | IEA | - | |
GO:0060045 | positive regulation of cardiac muscle cell proliferation | IDA | 9553078 | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0005576 | extracellular region | EXP | 1697263 |8622701 |9139660 |11294897 |16597617 | |
GO:0005576 | extracellular region | TAS | 10490103 | |
GO:0005615 | extracellular space | TAS | 2435575 |
Section IV. Protein-protein interaction annotation
Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
---|---|---|---|---|---|
API5 | AAC-11 | AAC11 | API5L1 | apoptosis inhibitor 5 | - | HPRD | 11075807 |
CD44 | CDW44 | CSPG8 | ECMR-III | HCELL | IN | LHR | MC56 | MDU2 | MDU3 | MGC10468 | MIC4 | MUTCH-I | Pgp1 | CD44 molecule (Indian blood group) | - | HPRD | 7532176 |
CEP57 | KIAA0092 | PIG8 | TSP57 | centrosomal protein 57kDa | - | HPRD | 12717444 |
CSNK2A1 | CK2A1 | CKII | casein kinase 2, alpha 1 polypeptide | - | HPRD,BioGRID | 12145206 |
CSNK2A2 | CK2A2 | CSNK2A1 | FLJ43934 | casein kinase 2, alpha prime polypeptide | Reconstituted Complex | BioGRID | 12145206 |
CSNK2A2 | CK2A2 | CSNK2A1 | FLJ43934 | casein kinase 2, alpha prime polypeptide | - | HPRD | 7735329 |
CSNK2B | CK2B | CK2N | CSK2B | G5A | MGC138222 | MGC138224 | casein kinase 2, beta polypeptide | Reconstituted Complex | BioGRID | 12145206 |
CXCL13 | ANGIE | ANGIE2 | BCA-1 | BCA1 | BLC | BLR1L | SCYB13 | chemokine (C-X-C motif) ligand 13 | - | HPRD | 11708770 |
FGFBP1 | FGFBP | HBP17 | fibroblast growth factor binding protein 1 | - | HPRD,BioGRID | 11509569 |
FGFR1 | BFGFR | CD331 | CEK | FGFBR | FLG | FLJ99988 | FLT2 | HBGFR | KAL2 | N-SAM | fibroblast growth factor receptor 1 | - | HPRD,BioGRID | 10950949 |11030354 |
FGFR2 | BEK | BFR-1 | CD332 | CEK3 | CFD1 | ECT1 | FLJ98662 | JWS | K-SAM | KGFR | TK14 | TK25 | fibroblast growth factor receptor 2 | - | HPRD | 10950949 |
FGFR4 | CD334 | JTK2 | MGC20292 | TKF | fibroblast growth factor receptor 4 | - | HPRD | 8530375 |
GPC3 | DGSX | OCI-5 | SDYS | SGB | SGBS | SGBS1 | glypican 3 | - | HPRD,BioGRID | 12478660 |
GPC4 | K-glypican | glypican 4 | - | HPRD,BioGRID | 11066092 |
HSPG2 | PLC | PRCAN | SJA | SJS | SJS1 | heparan sulfate proteoglycan 2 | - | HPRD | 11847221 |
NRP1 | BDCA4 | CD304 | DKFZp686A03134 | DKFZp781F1414 | NP1 | NRP | VEGF165R | neuropilin 1 | NRP1 (Npn-1) interacts with FGF2. This interaction was modeled on a demonstrated interaction between rat NRP1 and human FGF2. | BIND | 15695515 |
PF4 | CXCL4 | MGC138298 | SCYB4 | platelet factor 4 | - | HPRD | 9558385 |
RPL6 | SHUJUN-2 | TAXREB107 | TXREB1 | ribosomal protein L6 | - | HPRD,BioGRID | 9826564 |
RPS19 | DBA | ribosomal protein S19 | - | HPRD,BioGRID | 11716516 |
SDC1 | CD138 | SDC | SYND1 | syndecan | syndecan 1 | Co-purification | BioGRID | 16982797 |
SDC2 | HSPG | HSPG1 | SYND2 | syndecan 2 | Co-purification | BioGRID | 16982797 |
SDC3 | N-syndecan | SDCN | SYND3 | syndecan 3 | - | HPRD,BioGRID | 8344959 |
SDC4 | MGC22217 | SYND4 | syndecan 4 | Co-purification | BioGRID | 16982797 |
VTN | V75 | VN | VNT | vitronectin | - | HPRD,BioGRID | 11796824 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG MAPK SIGNALING PATHWAY | 267 | 205 | All SZGR 2.0 genes in this pathway |
KEGG REGULATION OF ACTIN CYTOSKELETON | 216 | 144 | All SZGR 2.0 genes in this pathway |
KEGG PATHWAYS IN CANCER | 328 | 259 | All SZGR 2.0 genes in this pathway |
KEGG MELANOMA | 71 | 57 | All SZGR 2.0 genes in this pathway |
BIOCARTA NFAT PATHWAY | 56 | 45 | All SZGR 2.0 genes in this pathway |
PID GLYPICAN 1PATHWAY | 27 | 20 | All SZGR 2.0 genes in this pathway |
PID ANGIOPOIETIN RECEPTOR PATHWAY | 50 | 41 | All SZGR 2.0 genes in this pathway |
PID AVB3 INTEGRIN PATHWAY | 75 | 53 | All SZGR 2.0 genes in this pathway |
PID SYNDECAN 4 PATHWAY | 32 | 25 | All SZGR 2.0 genes in this pathway |
PID FGF PATHWAY | 55 | 37 | All SZGR 2.0 genes in this pathway |
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING | 37 | 24 | All SZGR 2.0 genes in this pathway |
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE | 87 | 64 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY FGFR IN DISEASE | 127 | 88 | All SZGR 2.0 genes in this pathway |
REACTOME ACTIVATED POINT MUTANTS OF FGFR2 | 16 | 11 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY FGFR1 MUTANTS | 30 | 20 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | 11 | 8 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY FGFR3 MUTANTS | 11 | 9 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY FGFR MUTANTS | 44 | 29 | All SZGR 2.0 genes in this pathway |
REACTOME FRS2 MEDIATED CASCADE | 36 | 27 | All SZGR 2.0 genes in this pathway |
REACTOME PI 3K CASCADE | 56 | 39 | All SZGR 2.0 genes in this pathway |
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR | 100 | 74 | All SZGR 2.0 genes in this pathway |
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE | 54 | 40 | All SZGR 2.0 genes in this pathway |
REACTOME SHC MEDIATED CASCADE | 28 | 19 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY INSULIN RECEPTOR | 108 | 72 | All SZGR 2.0 genes in this pathway |
REACTOME FGFR LIGAND BINDING AND ACTIVATION | 22 | 15 | All SZGR 2.0 genes in this pathway |
REACTOME FGFR2C LIGAND BINDING AND ACTIVATION | 12 | 9 | All SZGR 2.0 genes in this pathway |
REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | 12 | 8 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY FGFR | 112 | 80 | All SZGR 2.0 genes in this pathway |
REACTOME FGFR1 LIGAND BINDING AND ACTIVATION | 14 | 9 | All SZGR 2.0 genes in this pathway |
REACTOME PI3K CASCADE | 71 | 51 | All SZGR 2.0 genes in this pathway |
PARENT MTOR SIGNALING DN | 46 | 29 | All SZGR 2.0 genes in this pathway |
SENGUPTA NASOPHARYNGEAL CARCINOMA UP | 294 | 178 | All SZGR 2.0 genes in this pathway |
CHARAFE BREAST CANCER LUMINAL VS BASAL DN | 455 | 304 | All SZGR 2.0 genes in this pathway |
BASAKI YBX1 TARGETS UP | 290 | 177 | All SZGR 2.0 genes in this pathway |
DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | All SZGR 2.0 genes in this pathway |
KOKKINAKIS METHIONINE DEPRIVATION 48HR DN | 64 | 39 | All SZGR 2.0 genes in this pathway |
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP | 117 | 84 | All SZGR 2.0 genes in this pathway |
STREICHER LSM1 TARGETS DN | 19 | 13 | All SZGR 2.0 genes in this pathway |
BAKER HEMATOPOESIS STAT1 TARGETS | 10 | 9 | All SZGR 2.0 genes in this pathway |
DACOSTA UV RESPONSE VIA ERCC3 DN | 855 | 609 | All SZGR 2.0 genes in this pathway |
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN | 483 | 336 | All SZGR 2.0 genes in this pathway |
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP | 811 | 508 | All SZGR 2.0 genes in this pathway |
FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE DN | 98 | 59 | All SZGR 2.0 genes in this pathway |
WU CELL MIGRATION | 184 | 114 | All SZGR 2.0 genes in this pathway |
BENPORATH ES 1 | 379 | 235 | All SZGR 2.0 genes in this pathway |
BENPORATH NANOG TARGETS | 988 | 594 | All SZGR 2.0 genes in this pathway |
BENPORATH OCT4 TARGETS | 290 | 172 | All SZGR 2.0 genes in this pathway |
BENPORATH SOX2 TARGETS | 734 | 436 | All SZGR 2.0 genes in this pathway |
BENPORATH NOS TARGETS | 179 | 105 | All SZGR 2.0 genes in this pathway |
AMIT EGF RESPONSE 240 HELA | 60 | 43 | All SZGR 2.0 genes in this pathway |
GEORGES CELL CYCLE MIR192 TARGETS | 62 | 46 | All SZGR 2.0 genes in this pathway |
GEORGES TARGETS OF MIR192 AND MIR215 | 893 | 528 | All SZGR 2.0 genes in this pathway |
STANELLE E2F1 TARGETS | 29 | 20 | All SZGR 2.0 genes in this pathway |
SMITH TERT TARGETS UP | 145 | 91 | All SZGR 2.0 genes in this pathway |
KANG IMMORTALIZED BY TERT UP | 89 | 61 | All SZGR 2.0 genes in this pathway |
REN ALVEOLAR RHABDOMYOSARCOMA DN | 408 | 274 | All SZGR 2.0 genes in this pathway |
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP | 314 | 201 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 16HR DN | 86 | 62 | All SZGR 2.0 genes in this pathway |
WANG SMARCE1 TARGETS DN | 371 | 218 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 14HR DN | 298 | 200 | All SZGR 2.0 genes in this pathway |
JI RESPONSE TO FSH DN | 58 | 43 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 20HR DN | 101 | 70 | All SZGR 2.0 genes in this pathway |
LU AGING BRAIN UP | 262 | 186 | All SZGR 2.0 genes in this pathway |
MA PITUITARY FETAL VS ADULT UP | 29 | 21 | All SZGR 2.0 genes in this pathway |
SATO SILENCED EPIGENETICALLY IN PANCREATIC CANCER | 49 | 30 | All SZGR 2.0 genes in this pathway |
GEISS RESPONSE TO DSRNA UP | 38 | 29 | All SZGR 2.0 genes in this pathway |
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN DN | 51 | 32 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 6HR DN | 160 | 101 | All SZGR 2.0 genes in this pathway |
KYNG DNA DAMAGE BY 4NQO OR GAMMA RADIATION | 15 | 13 | All SZGR 2.0 genes in this pathway |
KYNG DNA DAMAGE DN | 195 | 135 | All SZGR 2.0 genes in this pathway |
SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP | 180 | 114 | All SZGR 2.0 genes in this pathway |
MARZEC IL2 SIGNALING UP | 115 | 80 | All SZGR 2.0 genes in this pathway |
BASSO HAIRY CELL LEUKEMIA DN | 80 | 66 | All SZGR 2.0 genes in this pathway |
BONCI TARGETS OF MIR15A AND MIR16 1 | 91 | 75 | All SZGR 2.0 genes in this pathway |
BOQUEST STEM CELL CULTURED VS FRESH UP | 425 | 298 | All SZGR 2.0 genes in this pathway |
VART KSHV INFECTION ANGIOGENIC MARKERS DN | 138 | 92 | All SZGR 2.0 genes in this pathway |
JU AGING TERC TARGETS UP | 10 | 6 | All SZGR 2.0 genes in this pathway |
MIZUKAMI HYPOXIA UP | 12 | 12 | All SZGR 2.0 genes in this pathway |
MIZUKAMI HYPOXIA DN | 6 | 5 | All SZGR 2.0 genes in this pathway |
HINATA NFKB TARGETS FIBROBLAST UP | 84 | 60 | All SZGR 2.0 genes in this pathway |
POOLA INVASIVE BREAST CANCER DN | 134 | 83 | All SZGR 2.0 genes in this pathway |
MEISSNER NPC HCP WITH H3K4ME2 | 491 | 319 | All SZGR 2.0 genes in this pathway |
ZHAN MULTIPLE MYELOMA PR DN | 44 | 34 | All SZGR 2.0 genes in this pathway |
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D | 882 | 506 | All SZGR 2.0 genes in this pathway |
PLASARI TGFB1 TARGETS 10HR UP | 199 | 143 | All SZGR 2.0 genes in this pathway |
SMIRNOV RESPONSE TO IR 6HR UP | 166 | 97 | All SZGR 2.0 genes in this pathway |
GHANDHI DIRECT IRRADIATION UP | 110 | 68 | All SZGR 2.0 genes in this pathway |
GHANDHI BYSTANDER IRRADIATION UP | 86 | 54 | All SZGR 2.0 genes in this pathway |
NABA SECRETED FACTORS | 344 | 197 | All SZGR 2.0 genes in this pathway |
NABA MATRISOME ASSOCIATED | 753 | 411 | All SZGR 2.0 genes in this pathway |
NABA MATRISOME | 1028 | 559 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
miRNA family | Target position | miRNA ID | miRNA seq | ||
---|---|---|---|---|---|
UTR start | UTR end | Match method | |||
miR-103/107 | 5639 | 5645 | m8 | hsa-miR-103brain | AGCAGCAUUGUACAGGGCUAUGA |
hsa-miR-107brain | AGCAGCAUUGUACAGGGCUAUCA | ||||
miR-140 | 3774 | 3780 | 1A | hsa-miR-140brain | AGUGGUUUUACCCUAUGGUAG |
miR-15/16/195/424/497 | 5640 | 5647 | 1A,m8 | hsa-miR-15abrain | UAGCAGCACAUAAUGGUUUGUG |
hsa-miR-16brain | UAGCAGCACGUAAAUAUUGGCG | ||||
hsa-miR-15bbrain | UAGCAGCACAUCAUGGUUUACA | ||||
hsa-miR-195SZ | UAGCAGCACAGAAAUAUUGGC | ||||
hsa-miR-424 | CAGCAGCAAUUCAUGUUUUGAA | ||||
hsa-miR-497 | CAGCAGCACACUGUGGUUUGU | ||||
hsa-miR-15abrain | UAGCAGCACAUAAUGGUUUGUG | ||||
hsa-miR-16brain | UAGCAGCACGUAAAUAUUGGCG | ||||
hsa-miR-15bbrain | UAGCAGCACAUCAUGGUUUACA | ||||
hsa-miR-195SZ | UAGCAGCACAGAAAUAUUGGC | ||||
hsa-miR-424 | CAGCAGCAAUUCAUGUUUUGAA | ||||
hsa-miR-497 | CAGCAGCACACUGUGGUUUGU | ||||
miR-503 | 5600 | 5606 | 1A | hsa-miR-503 | UAGCAGCGGGAACAGUUCUGCAG |
hsa-miR-503 | UAGCAGCGGGAACAGUUCUGCAG |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.