SZGR2

Summary ?

GeneID	2261
Symbol	FGFR3
Synonyms	ACH\|CD333\|CEK2\|HSFGFR3EX\|JTK4
Description	fibroblast growth factor receptor 3
Reference	MIM:134934\|HGNC:HGNC:3690\|Ensembl:ENSG00000068078\|HPRD:00624\|Vega:OTTHUMG00000121148
Gene type	protein-coding
Map location	4p16.3
Pascal p-value	0.676
Sherlock p-value	0.043
Fetal beta	-3.174
eGene	Myers' cis & trans
Support	Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs16823850	chr3	115274498	FGFR3	2261		0.19		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SCPEP1	0.54	0.58
AC051642.1	0.53	0.53
CORO6	0.52	0.56
ANKRD19	0.51	0.49
PLA2G4C	0.50	0.54
CA7	0.50	0.55
HTATIP2	0.49	0.46
SLC48A1	0.49	0.54
TRPV3	0.49	0.51
PPAP2A	0.49	0.49

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
BCL7C	-0.40	-0.49
C19orf57	-0.38	-0.32
DPYSL3	-0.38	-0.31
FAM109A	-0.38	-0.37
KIAA1949	-0.37	-0.34
ISYNA1	-0.37	-0.34
KCTD11	-0.37	-0.35
C1orf187	-0.37	-0.34
FBLIM1	-0.37	-0.35
KIAA1211	-0.37	-0.31

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0004872	receptor activity	IEA		-
GO:0005007	fibroblast growth factor receptor activity	IEA		-
GO:0005007	fibroblast growth factor receptor activity	NAS		7923141
GO:0005524	ATP binding	IEA		-
GO:0004713	protein tyrosine kinase activity	IEA		-
GO:0016740	transferase activity	IEA		-
GO:0042802	identical protein binding	IPI		14732692
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0030900	forebrain development	IEA	Brain (GO term level: 8)	-
GO:0000165	MAPKKK cascade	IEA		-
GO:0000165	MAPKKK cascade	TAS		10918587
GO:0001501	skeletal system development	TAS		8601314
GO:0002009	morphogenesis of an epithelium	IEA		-
GO:0006468	protein amino acid phosphorylation	IEA		-
GO:0016049	cell growth	NAS		-
GO:0007259	JAK-STAT cascade	TAS		10918587
GO:0008543	fibroblast growth factor receptor signaling pathway	IEA		-
GO:0008543	fibroblast growth factor receptor signaling pathway	TAS		10918587
GO:0007605	sensory perception of sound	IEA		-
GO:0043065	positive regulation of apoptosis	IEA		-
GO:0031398	positive regulation of protein ubiquitination	IEA		-
GO:0050680	negative regulation of epithelial cell proliferation	IEA		-
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IEA		-
GO:0045597	positive regulation of cell differentiation	IEA		-
GO:0060113	inner ear receptor cell differentiation	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005764	lysosome	IEA		-
GO:0009898	internal side of plasma membrane	IEA		-
GO:0005886	plasma membrane	EXP		11294897 \|16597617
GO:0005887	integral to plasma membrane	TAS		10918587
GO:0048471	perinuclear region of cytoplasm	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ARAP1	CENTD2 \| KIAA0782	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	Two-hybrid	BioGRID	16169070
ATF3	-	activating transcription factor 3	Two-hybrid	BioGRID	16169070
C13orf34	BORA \| FLJ22624	chromosome 13 open reading frame 34	Two-hybrid	BioGRID	16169070
C6orf47	D6S53E \| G4 \| NG34	chromosome 6 open reading frame 47	-	HPRD,BioGRID	14667819
CCDC17	FLJ17921 \| FLJ33084	coiled-coil domain containing 17	Two-hybrid	BioGRID	16169070
CHGB	SCG1	chromogranin B (secretogranin 1)	Two-hybrid	BioGRID	16169070
CTSK	CTS02 \| CTSO \| CTSO1 \| CTSO2 \| MGC23107 \| PKND \| PYCD	cathepsin K	Two-hybrid	BioGRID	16169070
FGF1	AFGF \| ECGF \| ECGF-beta \| ECGFA \| ECGFB \| FGF-alpha \| FGFA \| GLIO703 \| HBGF1	fibroblast growth factor 1 (acidic)	-	HPRD,BioGRID	10574949
FGF8	AIGF \| HBGF-8 \| MGC149376	fibroblast growth factor 8 (androgen-induced)	-	HPRD,BioGRID	10574949
FGF9	GAF \| HBFG-9 \| MGC119914 \| MGC119915	fibroblast growth factor 9 (glia-activating factor)	-	HPRD,BioGRID	8576175 \|10574949
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	9045692
GTF3C1	DKFZp686A111 \| TFIIIC \| TFIIIC220 \| TFIIICalpha	general transcription factor IIIC, polypeptide 1, alpha 220kDa	Two-hybrid	BioGRID	16169070
HBZ	-	hemoglobin, zeta	Two-hybrid	BioGRID	16169070
HNRNPL	FLJ35509 \| HNRPL \| P/OKcl.14 \| hnRNP-L	heterogeneous nuclear ribonucleoprotein L	Two-hybrid	BioGRID	16169070
KIAA1377	-	KIAA1377	Two-hybrid	BioGRID	16169070
KRT8	CARD2 \| CK8 \| CYK8 \| K2C8 \| K8 \| KO	keratin 8	Two-hybrid	BioGRID	16169070
NDUFS6	-	NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)	Two-hybrid	BioGRID	16169070
POLA2	FLJ21662 \| FLJ37250	polymerase (DNA directed), alpha 2 (70kD subunit)	Two-hybrid	BioGRID	16169070
RADIL	FLJ10324 \| KIAA1849 \| MGC161589	Rap GTPase interactor	Two-hybrid	BioGRID	16169070
RNF130	G1RZFP \| GOLIATH \| GP \| MGC117241 \| MGC138647 \| MGC99542	ring finger protein 130	Two-hybrid	BioGRID	16169070
RPL8	-	ribosomal protein L8	Two-hybrid	BioGRID	16169070
SH2B1	DKFZp547G1110 \| FLJ30542 \| KIAA1299 \| SH2-B \| SH2B	SH2B adaptor protein 1	-	HPRD,BioGRID	11827956
SLC25A6	AAC3 \| ANT3 \| ANT3Y \| MGC17525	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6	Two-hybrid	BioGRID	16169070
SMG7	C1orf16 \| EST1C \| FLJ23717 \| KIAA0250 \| SGA56M \| SMG-7	Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)	Two-hybrid	BioGRID	16169070

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS	183	132	All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON	216	144	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG BLADDER CANCER	42	33	All SZGR 2.0 genes in this pathway
PID FGF PATHWAY	55	37	All SZGR 2.0 genes in this pathway
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING	37	24	All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE	87	64	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR3 MUTANTS	11	9	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR MUTANTS	44	29	All SZGR 2.0 genes in this pathway
REACTOME FRS2 MEDIATED CASCADE	36	27	All SZGR 2.0 genes in this pathway
REACTOME PI 3K CASCADE	56	39	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	100	74	All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE	54	40	All SZGR 2.0 genes in this pathway
REACTOME SHC MEDIATED CASCADE	28	19	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR	108	72	All SZGR 2.0 genes in this pathway
REACTOME FGFR LIGAND BINDING AND ACTIVATION	22	15	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR	112	80	All SZGR 2.0 genes in this pathway
REACTOME PI3K CASCADE	71	51	All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN	634	384	All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN	258	141	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP	544	308	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR UP	162	116	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN	229	142	All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS DN	25	13	All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS	1174	695	All SZGR 2.0 genes in this pathway
MATTIOLI MULTIPLE MYELOMA WITH 14Q32 TRANSLOCATIONS	36	25	All SZGR 2.0 genes in this pathway
AIYAR COBRA1 TARGETS DN	29	18	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP	309	199	All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS UP	110	71	All SZGR 2.0 genes in this pathway
WATTEL AUTONOMOUS THYROID ADENOMA UP	73	47	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP	487	286	All SZGR 2.0 genes in this pathway
SCHAEFFER SOX9 TARGETS IN PROSTATE DEVELOPMENT UP	21	19	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN	464	276	All SZGR 2.0 genes in this pathway
STANELLE E2F1 TARGETS	29	20	All SZGR 2.0 genes in this pathway
POMEROY MEDULLOBLASTOMA PROGNOSIS DN	43	28	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA SPIKED	22	13	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 UP	182	119	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA MS UP	48	32	All SZGR 2.0 genes in this pathway
YAGI AML FAB MARKERS	191	131	All SZGR 2.0 genes in this pathway
MUNSHI MULTIPLE MYELOMA UP	81	52	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C8	72	56	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP	390	242	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP	262	186	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 10HR UP	101	69	All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2	163	113	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN	287	208	All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1	419	273	All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS DN	141	92	All SZGR 2.0 genes in this pathway
BILD E2F3 ONCOGENIC SIGNATURE	246	153	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON UP	77	47	All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS DN	105	63	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN	292	189	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP	461	298	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN	281	179	All SZGR 2.0 genes in this pathway
FINETTI BREAST CANCERS KINOME BLUE	21	16	All SZGR 2.0 genes in this pathway
ENGELMANN CANCER PROGENITORS DN	70	44	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE UP	97	61	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN	701	446	All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS DN	108	64	All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A DN	108	68	All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION	175	125	All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP	323	240	All SZGR 2.0 genes in this pathway
BEIER GLIOMA STEM CELL UP	39	17	All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP	165	118	All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS DN	138	92	All SZGR 2.0 genes in this pathway
TOOKER GEMCITABINE RESISTANCE DN	122	84	All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER DN	134	83	All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER STEM CELL UP	47	38	All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS	535	325	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2	115	74	All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 DN	74	47	All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA2 UP	87	50	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR UP	61	44	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL	162	122	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP	570	339	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-181	296	302	1A	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-186	1123	1129	1A	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-194	1262	1268	1A	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-24	422	428	m8	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-99/100	537	544	1A,m8	hsa-miR-99a^brain	AACCCGUAGAUCCGAUCUUGUG
				hsa-miR-100^brain	AACCCGUAGAUCCGAACUUGUG
				hsa-miR-99b^brain	CACCCGUAGAACCGACCUUGCG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: FGFR3