Summary ?
Descriptionfour and a half LIM domains 3
Gene typeprotein-coding
Map location1p34
Pascal p-value0.061
Sherlock p-value0.332
Fetal beta0.264
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Nishioka_2013Genome-wide DNA methylation analysisThe authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADAMTSL4TSRC1ADAMTS-like 4Two-hybridBioGRID16189514 
CDC25B-cell division cycle 25 homolog B (S. pombe)-HPRD12681290 
CDC42EP1BORG5 | CEP1 | MGC15316 | MSE55CDC42 effector protein (Rho GTPase binding) 1Two-hybridBioGRID16189514 
CREB1CREB | MGC9284cAMP responsive element binding protein 1Affinity Capture-Western
CTBP2-C-terminal binding protein 2-HPRD,BioGRID12556451 
FHL2AAG11 | DRAL | SLIM3four and a half LIM domains 2-HPRD,BioGRID11135358 
FHL3MGC19547 | MGC23614 | MGC8696 | SLIM2four and a half LIM domains 3Two-hybridBioGRID11046156 
FHL3MGC19547 | MGC23614 | MGC8696 | SLIM2four and a half LIM domains 3-HPRD15117962 
FHL5ACT | FLJ33049 | KIAA0776 | RP3-393D12.2 | dJ393D12.2four and a half LIM domains 5Two-hybridBioGRID11046156 
ITGA7FLJ25220integrin, alpha 7Affinity Capture-Western
JTV1AIMP2 | P38 | PRO0992JTV1 geneTwo-hybridBioGRID16189514 
KLF3BKLF | MGC48279Kruppel-like factor 3 (basic)Affinity Capture-Western
Reconstituted Complex
KLF8BKLF3 | DKFZp686O08126 | DXS741 | MGC138314 | ZNF741Kruppel-like factor 8-HPRD12556451 
LASP1Lasp-1 | MLN50LIM and SH3 protein 1Two-hybridBioGRID16189514 
LNX1LNX | MPDZ | PDZRN2ligand of numb-protein X 1Two-hybridBioGRID16189514 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1-HPRD14729955 
MED15ARC105 | CAG7A | CTG7A | DKFZp686A2214 | DKFZp762B1216 | FLJ42282 | FLJ42935 | PCQAP | TIG-1 | TIG1 | TNRC7mediator complex subunit 15Two-hybridBioGRID16189514 
PAK7KIAA1264 | MGC26232 | PAK5p21 protein (Cdc42/Rac)-activated kinase 7Two-hybridBioGRID16189514 
PHC2EDR2 | HPH2 | MGC163502 | PH2polyhomeotic homolog 2 (Drosophila)Two-hybridBioGRID16189514 
RBM42MGC10433RNA binding motif protein 42Two-hybridBioGRID16189514 
RFX6MGC33442 | RFXDC1 | dJ955L16.1regulatory factor X, 6Two-hybridBioGRID16189514 
SRFMCM1serum response factor (c-fos serum response element-binding transcription factor)SRF interacts with FHL3. This interaction was modeled on a demonstrated interaction between human SRF and FHL3 from an unspecified species.BIND15610731 
TRIP6MGC10556 | MGC10558 | MGC29959 | MGC3837 | MGC4423 | OIP1 | ZRP-1thyroid hormone receptor interactor 6Two-hybridBioGRID16189514 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PARENT MTOR SIGNALING DN 4629All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 240 HELA 6043All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 6HR 5938All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 10871All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566371All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442263All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237159All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549316All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS DN 14888All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658397All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway