SZGR2

Summary ?

GeneID	2280
Symbol	FKBP1A
Synonyms	FKBP-12\|FKBP-1A\|FKBP1\|FKBP12\|PKC12\|PKCI2\|PPIASE
Description	FK506 binding protein 1A
Reference	MIM:186945\|HGNC:HGNC:3711\|Ensembl:ENSG00000088832\|HPRD:01741\|Vega:OTTHUMG00000031666
Gene type	protein-coding
Map location	20p13
Pascal p-value	0.007
Sherlock p-value	0.702
eGene	Myers' cis & trans Meta
Support	RNA AND PROTEIN SYNTHESIS

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.025

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs5995385	chr22	37519863	FKBP1A	2280		0.08		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
KANK2	0.78	0.82
COLEC12	0.77	0.77
TBX18	0.76	0.78
FOXC2	0.76	0.78
ITIH5	0.76	0.85
FLI1	0.71	0.79
GPR124	0.70	0.79
MDS1	0.70	0.72
EVI1	0.69	0.72
CDH5	0.69	0.73

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SNHG12	-0.34	-0.45
ZNF32	-0.33	-0.50
C12orf45	-0.32	-0.49
COX7C	-0.32	-0.42
MTIF3	-0.32	-0.43
ST20	-0.31	-0.43
RPS27L	-0.31	-0.39
ATP5E	-0.31	-0.50
AC132872.1	-0.30	-0.40
RPL41	-0.30	-0.46

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005024	transforming growth factor beta receptor activity	TAS		11322937
GO:0004872	receptor activity	TAS		7518616
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	IEA		-
GO:0005515	protein binding	IPI		12604780
GO:0016853	isomerase activity	IEA		-
GO:0005219	ryanodine-sensitive calcium-release channel activity	TAS		11322937
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003007	heart morphogenesis	ISS		-
GO:0055010	ventricular cardiac muscle morphogenesis	ISS		-
GO:0022417	protein maturation via protein folding	TAS		11322937
GO:0006457	protein folding	IEA		-
GO:0006458	'de novo' protein folding	TAS		11322937
GO:0042110	T cell activation	NAS		1696686
GO:0042026	protein refolding	TAS		11322937
GO:0032513	negative regulation of protein phosphatase type 2B activity	IDA		7592869
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	IMP		12761501
GO:0050776	regulation of immune response	IMP		2477715
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	IDA		1701173
GO:0005737	cytoplasm	IEA		-
GO:0014802	terminal cisterna	ISS		1374404

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BMPR1A	10q23del \| ACVRLK3 \| ALK3 \| CD292	bone morphogenetic protein receptor, type IA	Two-hybrid	BioGRID	9663660
DHFR	-	dihydrofolate reductase	Biochemical Activity	BioGRID	12812497
FKBP1A	FKBP-12 \| FKBP1 \| FKBP12 \| FKBP12C \| PKC12 \| PKCI2 \| PPIASE	FK506 binding protein 1A, 12kDa	-	HPRD,BioGRID	9871618 \|10852943
FKBP4	FKBP52 \| FKBP59 \| HBI \| Hsp56 \| PPIase \| p52	FK506 binding protein 4, 59kDa	-	HPRD	11164950
FRAP1	FLJ44809 \| FRAP \| FRAP2 \| MTOR \| RAFT1 \| RAPT1	FK506 binding protein 12-rapamycin associated protein 1	-	HPRD,BioGRID	8662507
FRAP1	FLJ44809 \| FRAP \| FRAP2 \| MTOR \| RAFT1 \| RAPT1	FK506 binding protein 12-rapamycin associated protein 1	mTOR interacts with FKBP12 bound to rapamycin. This interaction was modeled on a demonstrated interaction between human mTOR and mouse FKBP12.	BIND	15467718
GLMN	FAP \| FAP48 \| FAP68 \| FKBPAP \| GLML \| GVM \| VMGLOM	glomulin, FKBP associated protein	-	HPRD,BioGRID	8955134
ITPR1	INSP3R1 \| IP3R \| IP3R1 \| SCA15 \| SCA16	inositol 1,4,5-triphosphate receptor, type 1	-	HPRD,BioGRID	9346894
KIAA1303	-	raptor	Affinity Capture-Western	BioGRID	15268862 \|15467718
PPP3CA	CALN \| CALNA \| CALNA1 \| CCN1 \| CNA1 \| PPP2B	protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform	-	HPRD	7543369
PPP3R1	CALNB1 \| CNB \| CNB1	protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform	-	HPRD	7541044
RYR1	CCO \| MHS \| MHS1 \| RYDR \| RYR \| SKRR	ryanodine receptor 1 (skeletal)	-	HPRD,BioGRID	11171121 \|11279144 \|12704193\|11237759
RYR3	-	ryanodine receptor 3	-	HPRD,BioGRID	11171121 \|11598113
TGFB1I1	ARA55 \| HIC-5 \| HIC5 \| TSC-5	transforming growth factor beta 1 induced transcript 1	-	HPRD	12417722
TGFBR1	AAT5 \| ACVRLK4 \| ALK-5 \| ALK5 \| LDS1A \| LDS2A \| SKR4 \| TGFR-1	transforming growth factor, beta receptor 1	-	HPRD,BioGRID	7518616
TGFBR1	AAT5 \| ACVRLK4 \| ALK-5 \| ALK5 \| LDS1A \| LDS2A \| SKR4 \| TGFR-1	transforming growth factor, beta receptor 1	T-beta-R1 interacts with FKBP12. This interaction was modeled on a demonstrated interaction between T-beta-R1 and FKBP12 both from unspecified species.	BIND	15761148
TRPC3	TRP3	transient receptor potential cation channel, subfamily C, member 3	-	HPRD	15199065
YY1	DELTA \| INO80S \| NF-E1 \| UCRBP \| YIN-YANG-1	YY1 transcription factor	Two-hybrid	BioGRID	7541038

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
BIOCARTA MTOR PATHWAY	23	15	All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY	56	45	All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY	54	47	All SZGR 2.0 genes in this pathway
PID ALK1 PATHWAY	26	21	All SZGR 2.0 genes in this pathway
PID ALK2 PATHWAY	11	9	All SZGR 2.0 genes in this pathway
PID TCR CALCIUM PATHWAY	29	23	All SZGR 2.0 genes in this pathway
PID ALPHA SYNUCLEIN PATHWAY	33	25	All SZGR 2.0 genes in this pathway
PID TGFBR PATHWAY	55	38	All SZGR 2.0 genes in this pathway
REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	16	7	All SZGR 2.0 genes in this pathway
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	26	16	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX	63	42	All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP	567	375	All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN	634	384	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
PUIFFE INVASION INHIBITED BY ASCITES UP	82	51	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP	368	234	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN	455	304	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
WIKMAN ASBESTOS LUNG CANCER DN	28	13	All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN	335	193	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
LUI THYROID CANCER PAX8 PPARG DN	45	29	All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP	584	356	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP	309	199	All SZGR 2.0 genes in this pathway
LIANG HEMATOPOIESIS STEM CELL NUMBER LARGE VS TINY UP	44	24	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN	411	249	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS UP	266	171	All SZGR 2.0 genes in this pathway
OKUMURA INFLAMMATORY RESPONSE LPS	183	115	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA SUBGROUPS	30	20	All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION	475	313	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN	225	163	All SZGR 2.0 genes in this pathway
BRUNO HEMATOPOIESIS	66	48	All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM DN	141	99	All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN	153	120	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN UP	71	49	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR	681	420	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP	123	75	All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN	161	105	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP	148	96	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN	270	181	All SZGR 2.0 genes in this pathway
CHUNG BLISTER CYTOTOXICITY DN	44	29	All SZGR 2.0 genes in this pathway
WU ALZHEIMER DISEASE UP	14	8	All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN	442	275	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17	181	101	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 UP	140	94	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A	898	516	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP	259	159	All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN	321	200	All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3	824	528	All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP	279	155	All SZGR 2.0 genes in this pathway
HOLLEMAN VINCRISTINE RESISTANCE ALL UP	27	16	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-135	467	474	1A,m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	467	474	1A,m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-142-3p	659	666	1A,m8	hsa-miR-142-3p	UGUAGUGUUUCCUACUUUAUGGA
miR-181	139	145	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-183	226	232	1A	hsa-miR-183	UAUGGCACUGGUAGAAUUCACUG
miR-218	336	342	1A	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-25/32/92/363/367	1099	1105	1A	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-320	157	163	m8	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-338	913	919	m8	hsa-miR-338^brain	UCCAGCAUCAGUGAUUUUGUUGA
miR-369-3p	432	438	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	432	438	m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-381	117	123	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-410	434	440	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: FKBP1A