Gene Page: RAB11FIP2

Summary ?
GeneID22841
SymbolRAB11FIP2
SynonymsRab11-FIP2|nRip11
DescriptionRAB11 family interacting protein 2 (class I)
ReferenceMIM:608599|HGNC:HGNC:29152|Ensembl:ENSG00000107560|HPRD:10548|Vega:OTTHUMG00000019128
Gene typeprotein-coding
Map location10q26.11
Pascal p-value0.414
Sherlock p-value0.547
Fetal beta-0.352
DMG1 (# studies)
SupportG2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.humanPSD
G2Cdb.humanPSP

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg0229124510119780037RAB11FIP22.269E-4-0.2990.036DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GRIN2A0.820.74
KCNB10.810.65
TRHDE0.810.69
PLCB10.800.59
KLF90.800.70
CREG20.790.66
TMEM132D0.790.74
GCC20.790.74
ARHGAP260.790.72
CMTM40.790.68
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
BCL7C-0.46-0.62
AC135586.1-0.41-0.53
TRAF4-0.41-0.57
UBE2L6-0.41-0.46
RPL18-0.40-0.62
RPL35-0.40-0.57
FAU-0.40-0.55
RPLP1-0.40-0.56
RPL36-0.40-0.59
RPS18-0.40-0.58

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AP2A1ADTAA | AP2-ALPHA | CLAPA1adaptor-related protein complex 2, alpha 1 subunit-HPRD,BioGRID12364336 
EPS15AF-1P | AF1P | MLLT5epidermal growth factor receptor pathway substrate 15Affinity Capture-WesternBioGRID12364336 
IL8RBCD182 | CDw128b | CMKAR2 | CXCR2 | IL8R2 | IL8RAinterleukin 8 receptor, beta-HPRD,BioGRID15004234 
MYO5BKIAA1119myosin VB-HPRD,BioGRID11495908 |12393859 
RAB11AMGC1490 | YL8RAB11A, member RAS oncogene family-HPRD15304524 
RAB11AMGC1490 | YL8RAB11A, member RAS oncogene family-HPRD,BioGRID11495908 |11994279 
RAB11BH-YPT3 | MGC133246RAB11B, member RAS oncogene family-HPRD,BioGRID11495908 
RAB11FIP1DKFZp686E2214 | FLJ22524 | FLJ22622 | MGC78448 | NOEL1A | RCP | rab11-FIP1RAB11 family interacting protein 1 (class I)Affinity Capture-WesternBioGRID12364336 
RAB11FIP2KIAA0941 | Rab11-FIP2 | nRip11RAB11 family interacting protein 2 (class I)Affinity Capture-Western
Two-hybrid		BioGRID11994279 |12364336 
RAB11FIP4FLJ00131 | KIAA1821 | MGC11316 | MGC126566 | RAB11-FIP4RAB11 family interacting protein 4 (class II)-HPRD,BioGRID12470645 
RAB11FIP5DKFZp434H018 | GAF1 | KIAA0857 | RIP11 | pp75RAB11 family interacting protein 5 (class I)Affinity Capture-WesternBioGRID12364336 
RAB25CATX-8RAB25, member RAS oncogene family-HPRD,BioGRID11481332 
RAB25CATX-8RAB25, member RAS oncogene family-HPRD11495908 
REPS1RALBP1RALBP1 associated Eps domain containing 1Affinity Capture-WesternBioGRID12364336 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide-HPRD15324660 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG ENDOCYTOSIS 183132All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413270All SZGR 2.0 genes in this pathway
REACTOME AQUAPORIN MEDIATED TRANSPORT 5134All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 4430All SZGR 2.0 genes in this pathway
PUIFFE INVASION INHIBITED BY ASCITES DN 14591All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP DN 199124All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800473All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF DN 10364All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314201All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE DN 209137All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442275All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 UP 176110All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN 414237All SZGR 2.0 genes in this pathway
GABRIELY MIR21 TARGETS 289187All SZGR 2.0 genes in this pathway
LINSLEY MIR16 TARGETS 206127All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337236All SZGR 2.0 genes in this pathway