Gene Page: ARHGEF15
Summary ?
| GeneID | 22899 |
| Symbol | ARHGEF15 |
| Synonyms | ARGEF15|E5|Ephexin5|Vsm-RhoGEF |
| Description | Rho guanine nucleotide exchange factor 15 |
| Reference | MIM:608504|HGNC:HGNC:15590|Ensembl:ENSG00000198844|HPRD:10535|Vega:OTTHUMG00000108187 |
| Gene type | protein-coding |
| Map location | 17p13.1 |
| Pascal p-value | 0.196 |
| Fetal beta | 0.018 |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ARHGEF15 | chr17 | 8222069 | C | T | NM_025014 NM_025014 NM_173728 NM_173728 | . p.625A>V . p.625A>V | splice missense splice missense | Schizophrenia | DNM:Fromer_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| TSC2 | 0.95 | 0.95 |
| MEN1 | 0.95 | 0.96 |
| EDC4 | 0.95 | 0.95 |
| ZNF574 | 0.95 | 0.96 |
| RBM14 | 0.95 | 0.95 |
| PCNXL3 | 0.95 | 0.95 |
| USP19 | 0.94 | 0.94 |
| ATP13A1 | 0.94 | 0.95 |
| C17orf63 | 0.94 | 0.94 |
| ATXN2L | 0.94 | 0.95 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.75 | -0.84 |
| MT-CO2 | -0.74 | -0.85 |
| AF347015.27 | -0.72 | -0.83 |
| AF347015.33 | -0.71 | -0.81 |
| MT-CYB | -0.71 | -0.81 |
| AF347015.8 | -0.70 | -0.83 |
| S100B | -0.70 | -0.81 |
| AF347015.21 | -0.70 | -0.90 |
| C5orf53 | -0.70 | -0.74 |
| COPZ2 | -0.68 | -0.76 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BIOCARTA MYOSIN PATHWAY | 31 | 22 | All SZGR 2.0 genes in this pathway |
| BIOCARTA PAR1 PATHWAY | 37 | 28 | All SZGR 2.0 genes in this pathway |
| PID RHOA REG PATHWAY | 46 | 30 | All SZGR 2.0 genes in this pathway |
| PID EPHA FWDPATHWAY | 34 | 29 | All SZGR 2.0 genes in this pathway |
| GAL LEUKEMIC STEM CELL DN | 244 | 153 | All SZGR 2.0 genes in this pathway |
| MOREAUX MULTIPLE MYELOMA BY TACI UP | 412 | 249 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE INCIPIENT UP | 390 | 242 | All SZGR 2.0 genes in this pathway |
| SU PANCREAS | 54 | 30 | All SZGR 2.0 genes in this pathway |
| CUI TCF21 TARGETS 2 DN | 830 | 547 | All SZGR 2.0 genes in this pathway |
| BAELDE DIABETIC NEPHROPATHY UP | 86 | 48 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| ZHENG IL22 SIGNALING DN | 42 | 26 | All SZGR 2.0 genes in this pathway |
| BOQUEST STEM CELL DN | 216 | 143 | All SZGR 2.0 genes in this pathway |
| WEST ADRENOCORTICAL TUMOR DN | 546 | 362 | All SZGR 2.0 genes in this pathway |
| YAMASHITA LIVER CANCER STEM CELL UP | 47 | 38 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |