Gene Page: EPN2
Summary ?
| GeneID | 22905 |
| Symbol | EPN2 |
| Synonyms | EHB21 |
| Description | epsin 2 |
| Reference | MIM:607263|HGNC:HGNC:18639|Ensembl:ENSG00000072134|HPRD:06271|Vega:OTTHUMG00000187034 |
| Gene type | protein-coding |
| Map location | 17p11.2 |
| Pascal p-value | 6.085E-6 |
| Sherlock p-value | 0.205 |
| Fetal beta | -0.509 |
| DMG | 1 (# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg24028141 | 17 | 19186579 | EPN2 | 2E-6 | 0.338 | 0.008 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| TTC28 | 0.92 | 0.84 |
| SRGAP1 | 0.91 | 0.83 |
| DOPEY2 | 0.91 | 0.83 |
| SEMA3A | 0.90 | 0.80 |
| C20orf74 | 0.90 | 0.88 |
| ZEB2 | 0.90 | 0.89 |
| VASH2 | 0.90 | 0.76 |
| MLLT3 | 0.90 | 0.84 |
| ZSCAN2 | 0.90 | 0.80 |
| LRCH1 | 0.90 | 0.83 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PTH1R | -0.63 | -0.72 |
| C5orf53 | -0.61 | -0.68 |
| SLC16A11 | -0.61 | -0.63 |
| TNFSF12 | -0.61 | -0.64 |
| AIFM3 | -0.61 | -0.67 |
| RAMP1 | -0.61 | -0.73 |
| AC007405.8 | -0.61 | -0.66 |
| IFI27 | -0.60 | -0.80 |
| TMEM54 | -0.60 | -0.61 |
| HSD17B14 | -0.60 | -0.69 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG ENDOCYTOSIS | 183 | 132 | All SZGR 2.0 genes in this pathway |
| CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN | 391 | 222 | All SZGR 2.0 genes in this pathway |
| DOANE RESPONSE TO ANDROGEN UP | 184 | 125 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC3 TARGETS DN | 536 | 332 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN | 770 | 415 | All SZGR 2.0 genes in this pathway |
| JOHANSSON GLIOMAGENESIS BY PDGFB UP | 58 | 44 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER UP | 181 | 108 | All SZGR 2.0 genes in this pathway |
| OXFORD RALA TARGETS DN | 10 | 8 | All SZGR 2.0 genes in this pathway |
| AMIT EGF RESPONSE 240 HELA | 60 | 43 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 17P11 AMPLICON | 10 | 8 | All SZGR 2.0 genes in this pathway |
| CUI TCF21 TARGETS 2 DN | 830 | 547 | All SZGR 2.0 genes in this pathway |
| IWANAGA CARCINOGENESIS BY KRAS PTEN DN | 353 | 226 | All SZGR 2.0 genes in this pathway |
| SENGUPTA EBNA1 ANTICORRELATED | 173 | 85 | All SZGR 2.0 genes in this pathway |
| HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP | 242 | 159 | All SZGR 2.0 genes in this pathway |
| KOINUMA TARGETS OF SMAD2 OR SMAD3 | 824 | 528 | All SZGR 2.0 genes in this pathway |
| RAO BOUND BY SALL4 ISOFORM B | 517 | 302 | All SZGR 2.0 genes in this pathway |