Gene Page: FAN1
Summary ?
| GeneID | 22909 |
| Symbol | FAN1 |
| Synonyms | KIAA1018|KMIN|MTMR15|hFAN1 |
| Description | FANCD2/FANCI-associated nuclease 1 |
| Reference | MIM:613534|HGNC:HGNC:29170|Ensembl:ENSG00000198690|HPRD:17205|Vega:OTTHUMG00000175661 |
| Gene type | protein-coding |
| Map location | 15q13.3 |
| Pascal p-value | 0.354 |
| Sherlock p-value | 0.744 |
| Fetal beta | 0.03 |
| eGene | Cerebellum |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CNV:YES | Copy number variation studies | Manual curation | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SLC9A1 | 0.88 | 0.88 |
| C2CD2L | 0.87 | 0.92 |
| GRIN1 | 0.86 | 0.93 |
| ADCY3 | 0.86 | 0.83 |
| CAMK2B | 0.86 | 0.88 |
| TOMM34 | 0.85 | 0.88 |
| RAP1GAP | 0.85 | 0.89 |
| NDRG4 | 0.85 | 0.92 |
| NPTN | 0.85 | 0.90 |
| STIM1 | 0.85 | 0.83 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| FAM36A | -0.42 | -0.36 |
| GTF3C6 | -0.41 | -0.39 |
| RPS20 | -0.41 | -0.51 |
| RBMX2 | -0.40 | -0.39 |
| SNRPG | -0.40 | -0.50 |
| C9orf46 | -0.40 | -0.41 |
| RPL13AP22 | -0.38 | -0.56 |
| RPL34 | -0.38 | -0.46 |
| RPL38 | -0.38 | -0.51 |
| RPL31 | -0.38 | -0.40 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID FANCONI PATHWAY | 47 | 28 | All SZGR 2.0 genes in this pathway |
| DAVICIONI MOLECULAR ARMS VS ERMS UP | 332 | 228 | All SZGR 2.0 genes in this pathway |
| GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE DN | 61 | 35 | All SZGR 2.0 genes in this pathway |
| LIU BREAST CANCER | 30 | 19 | All SZGR 2.0 genes in this pathway |
| BENPORATH CYCLING GENES | 648 | 385 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR UP | 953 | 554 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR UP | 783 | 442 | All SZGR 2.0 genes in this pathway |
| GRADE COLON AND RECTAL CANCER DN | 101 | 65 | All SZGR 2.0 genes in this pathway |
| VANTVEER BREAST CANCER ESR1 UP | 167 | 99 | All SZGR 2.0 genes in this pathway |
| JISON SICKLE CELL DISEASE DN | 181 | 97 | All SZGR 2.0 genes in this pathway |
| WHITFIELD CELL CYCLE G2 | 182 | 102 | All SZGR 2.0 genes in this pathway |
| KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP | 756 | 494 | All SZGR 2.0 genes in this pathway |
| KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP | 682 | 440 | All SZGR 2.0 genes in this pathway |