Gene Page: P2RX2

Summary ?
GeneID22953
SymbolP2RX2
SynonymsDFNA41|P2X2
Descriptionpurinergic receptor P2X 2
ReferenceMIM:600844|HGNC:HGNC:15459|Ensembl:ENSG00000187848|HPRD:15984|Vega:OTTHUMG00000168018
Gene typeprotein-coding
Map location12q24.33
Pascal p-value0.031
eGeneAnterior cingulate cortex BA24
Cortex
Frontal Cortex BA9

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
ExpressionMeta-analysis of gene expressionP value: 1.413 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs446997512133169007P2RX2ENSG00000187848.82.261E-60.01-26359gtex_brain_ba24
rs488363012133200087P2RX2ENSG00000187848.81.661E-60.014721gtex_brain_ba24
rs488354312133202004P2RX2ENSG00000187848.81.016E-60.016638gtex_brain_ba24
rs1223002212133205160P2RX2ENSG00000187848.81.003E-60.019794gtex_brain_ba24
rs488354112133205655P2RX2ENSG00000187848.81.024E-60.0110289gtex_brain_ba24
rs748566812133206166P2RX2ENSG00000187848.87.746E-70.0110800gtex_brain_ba24
rs574503112133208611P2RX2ENSG00000187848.86.069E-70.0113245gtex_brain_ba24
rs574502812133208739P2RX2ENSG00000187848.86.063E-70.0113373gtex_brain_ba24
rs574502312133208886P2RX2ENSG00000187848.86.078E-70.0113520gtex_brain_ba24
rs574499912133211753P2RX2ENSG00000187848.85.94E-70.0116387gtex_brain_ba24
rs488362412133212737P2RX2ENSG00000187848.83.046E-80.0117371gtex_brain_ba24
rs488362012133212974P2RX2ENSG00000187848.85.967E-70.0117608gtex_brain_ba24
rs488361912133213121P2RX2ENSG00000187848.86.202E-70.0117755gtex_brain_ba24
rs488361812133214130P2RX2ENSG00000187848.86.409E-70.0118764gtex_brain_ba24
rs574497612133214441P2RX2ENSG00000187848.82.147E-70.0119075gtex_brain_ba24
rs574496012133216248P2RX2ENSG00000187848.86.207E-70.0120882gtex_brain_ba24
rs488361712133216617P2RX2ENSG00000187848.81.353E-70.0121251gtex_brain_ba24
rs488361612133217245P2RX2ENSG00000187848.85.969E-70.0121879gtex_brain_ba24
rs1087048212133217346P2RX2ENSG00000187848.81.353E-70.0121980gtex_brain_ba24
rs488361512133217872P2RX2ENSG00000187848.86.207E-70.0122506gtex_brain_ba24
rs574495112133218724P2RX2ENSG00000187848.81.353E-70.0123358gtex_brain_ba24
rs574494412133219831P2RX2ENSG00000187848.81.353E-70.0124465gtex_brain_ba24
rs19989465312133220991P2RX2ENSG00000187848.84.754E-70.0125625gtex_brain_ba24
rs574493112133220992P2RX2ENSG00000187848.85.55E-70.0125626gtex_brain_ba24
rs1078162612133222644P2RX2ENSG00000187848.81.348E-70.0127278gtex_brain_ba24
rs795838112133222861P2RX2ENSG00000187848.81.348E-70.0127495gtex_brain_ba24
rs5638019412133223390P2RX2ENSG00000187848.81.337E-70.0128024gtex_brain_ba24
rs797323812133223642P2RX2ENSG00000187848.81.346E-70.0128276gtex_brain_ba24
rs795492812133224393P2RX2ENSG00000187848.85.919E-70.0129027gtex_brain_ba24
rs797414012133224410P2RX2ENSG00000187848.85.919E-70.0129044gtex_brain_ba24
rs488353812133225446P2RX2ENSG00000187848.81.353E-70.0130080gtex_brain_ba24
rs488353712133226196P2RX2ENSG00000187848.81.353E-70.0130830gtex_brain_ba24
rs5929220512133227555P2RX2ENSG00000187848.85.969E-70.0132189gtex_brain_ba24
rs795685012133227619P2RX2ENSG00000187848.86.207E-70.0132253gtex_brain_ba24
rs795717112133227827P2RX2ENSG00000187848.85.976E-70.0132461gtex_brain_ba24
rs656089512133228117P2RX2ENSG00000187848.86.204E-70.0132751gtex_brain_ba24
rs656089612133228453P2RX2ENSG00000187848.86.207E-70.0133087gtex_brain_ba24
rs20022372812133230442P2RX2ENSG00000187848.81.123E-70.0135076gtex_brain_ba24
rs7107646512133230445P2RX2ENSG00000187848.81.102E-70.0135079gtex_brain_ba24
rs5636628612133230451P2RX2ENSG00000187848.81.101E-70.0135085gtex_brain_ba24
rs713575912133232405P2RX2ENSG00000187848.81.325E-70.0137039gtex_brain_ba24
rs730379112133232594P2RX2ENSG00000187848.81.644E-70.0137228gtex_brain_ba24
rs574488412133234389P2RX2ENSG00000187848.85.918E-70.0139023gtex_brain_ba24
rs20166860212133234392P2RX2ENSG00000187848.82.115E-60.0139026gtex_brain_ba24
rs1068757912133234741P2RX2ENSG00000187848.82.343E-70.0139375gtex_brain_ba24
rs574487412133235157P2RX2ENSG00000187848.81.353E-70.0139791gtex_brain_ba24
rs574486712133235789P2RX2ENSG00000187848.81.353E-70.0140423gtex_brain_ba24
rs574485712133236000P2RX2ENSG00000187848.81.353E-70.0140634gtex_brain_ba24
rs574485312133236425P2RX2ENSG00000187848.81.917E-70.0141059gtex_brain_ba24
rs574484412133238076P2RX2ENSG00000187848.85.969E-70.0142710gtex_brain_ba24
rs748911212133238679P2RX2ENSG00000187848.85.969E-70.0143313gtex_brain_ba24
rs574483812133240181P2RX2ENSG00000187848.81.353E-70.0144815gtex_brain_ba24
rs488359212133240782P2RX2ENSG00000187848.81.353E-70.0145416gtex_brain_ba24
rs488358612133242140P2RX2ENSG00000187848.86.207E-70.0146774gtex_brain_ba24
rs488357912133242795P2RX2ENSG00000187848.85.969E-70.0147429gtex_brain_ba24
rs574481112133243226P2RX2ENSG00000187848.85.969E-70.0147860gtex_brain_ba24
rs574481012133243281P2RX2ENSG00000187848.85.942E-70.0147915gtex_brain_ba24
rs574480812133243347P2RX2ENSG00000187848.81.353E-70.0147981gtex_brain_ba24
rs574480512133243650P2RX2ENSG00000187848.85.969E-70.0148284gtex_brain_ba24
rs488357712133243788P2RX2ENSG00000187848.86.207E-70.0148422gtex_brain_ba24
rs574479812133245149P2RX2ENSG00000187848.81.393E-70.0149783gtex_brain_ba24
rs574479212133246468P2RX2ENSG00000187848.85.969E-70.0151102gtex_brain_ba24
rs574479112133246543P2RX2ENSG00000187848.81.353E-70.0151177gtex_brain_ba24
rs1114699812133246859P2RX2ENSG00000187848.81.069E-60.0151493gtex_brain_ba24
rs574478912133247985P2RX2ENSG00000187848.85.969E-70.0152619gtex_brain_ba24
rs574478312133249017P2RX2ENSG00000187848.85.969E-70.0153651gtex_brain_ba24
rs574478012133249139P2RX2ENSG00000187848.86.207E-70.0153773gtex_brain_ba24
rs488355512133250118P2RX2ENSG00000187848.85.969E-70.0154752gtex_brain_ba24
rs574477412133250442P2RX2ENSG00000187848.81.353E-70.0155076gtex_brain_ba24
rs574477212133250569P2RX2ENSG00000187848.86.207E-70.0155203gtex_brain_ba24
rs574476712133250789P2RX2ENSG00000187848.81.673E-70.0155423gtex_brain_ba24
rs488354512133252556P2RX2ENSG00000187848.87.172E-70.0157190gtex_brain_ba24
rs574475712133253310P2RX2ENSG00000187848.86.205E-70.0157944gtex_brain_ba24
rs574475012133254083P2RX2ENSG00000187848.86.203E-70.0158717gtex_brain_ba24
rs574474512133255792P2RX2ENSG00000187848.81.352E-70.0160426gtex_brain_ba24
rs20104890212133257998P2RX2ENSG00000187848.88.533E-70.0162632gtex_brain_ba24
rs574473212133257999P2RX2ENSG00000187848.81.108E-70.0162633gtex_brain_ba24
rs574473112133258088P2RX2ENSG00000187848.81.342E-70.0162722gtex_brain_ba24
rs20220340912133258884P2RX2ENSG00000187848.89.387E-70.0163518gtex_brain_ba24
rs6169335912133258897P2RX2ENSG00000187848.81.681E-60.0163531gtex_brain_ba24
rs730784512133259157P2RX2ENSG00000187848.81.267E-60.0163791gtex_brain_ba24
rs412844912133259920P2RX2ENSG00000187848.81.351E-70.0164554gtex_brain_ba24
rs963029312133260288P2RX2ENSG00000187848.86.202E-70.0164922gtex_brain_ba24
rs1114700312133260381P2RX2ENSG00000187848.81.351E-70.0165015gtex_brain_ba24
rs1242249212133261750P2RX2ENSG00000187848.81.703E-70.0166384gtex_brain_ba24
rs1160923512133262922P2RX2ENSG00000187848.87.153E-70.0167556gtex_brain_ba24
rs207578412133263825P2RX2ENSG00000187848.82.888E-70.0168459gtex_brain_ba24
rs1153853412133264332P2RX2ENSG00000187848.82.395E-60.0168966gtex_brain_ba24
rs3583945012133269053P2RX2ENSG00000187848.81.921E-60.0173687gtex_brain_ba24
rs1078162712133272380P2RX2ENSG00000187848.83.726E-70.0177014gtex_brain_ba24
rs713561012133273255P2RX2ENSG00000187848.84.497E-70.0177889gtex_brain_ba24
rs1237083212133274145P2RX2ENSG00000187848.89.356E-70.0178779gtex_brain_ba24
rs1087049312133275050P2RX2ENSG00000187848.83.651E-70.0179684gtex_brain_ba24
rs1087049412133276284P2RX2ENSG00000187848.87.895E-80.0180918gtex_brain_ba24
rs713196312133278634P2RX2ENSG00000187848.83.595E-70.0183268gtex_brain_ba24
rs1078162912133280243P2RX2ENSG00000187848.83.595E-70.0184877gtex_brain_ba24
rs1078163012133280352P2RX2ENSG00000187848.81.134E-60.0184986gtex_brain_ba24
rs1000712133281462P2RX2ENSG00000187848.83.571E-70.0186096gtex_brain_ba24
rs5951443312133282320P2RX2ENSG00000187848.83.934E-70.0186954gtex_brain_ba24
rs6195213312133282353P2RX2ENSG00000187848.82.083E-60.0186987gtex_brain_ba24
rs1087049512133282661P2RX2ENSG00000187848.84.739E-70.0187295gtex_brain_ba24
rs1087049612133282703P2RX2ENSG00000187848.81.785E-60.0187337gtex_brain_ba24
rs796590412133286077P2RX2ENSG00000187848.84.11E-70.0190711gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ZMYM20.950.96
PDS5A0.940.96
FBXO110.940.96
BCLAF10.940.97
C4orf410.940.96
THUMPD10.940.95
AP1G10.940.95
TP53BP10.940.95
PUM20.930.95
UBA60.930.95
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FXYD1-0.79-0.86
AF347015.31-0.79-0.87
MT-CO2-0.78-0.87
AF347015.33-0.76-0.82
HIGD1B-0.75-0.85
AF347015.27-0.75-0.83
AF347015.8-0.74-0.85
MT-CYB-0.74-0.83
IFI27-0.74-0.83
HSD17B14-0.74-0.78

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0015276ligand-gated ion channel activityTASNeurotransmitter (GO term level: 8)9119082 
GO:0001614purinergic nucleotide receptor activityNAS17895406 
GO:0004872receptor activityIEA-
GO:0004931ATP-gated cation channel activityNAS17895406 
GO:0005524ATP bindingIEA-
GO:0042803protein homodimerization activityNAS17895406 
GO:0046982protein heterodimerization activityNAS17895406 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0010524positive regulation of calcium ion transport into cytosolNAS17895406 
GO:0006811ion transportIEA-
GO:0050850positive regulation of calcium-mediated signalingNAS17895406 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CALCIUM SIGNALING PATHWAY 178134All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795478All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 12Q24 AMPLICON 157All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536296All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
TAVAZOIE METASTASIS 10868All SZGR 2.0 genes in this pathway
STAMBOLSKY RESPONSE TO VITAMIN D3 UP 8448All SZGR 2.0 genes in this pathway
BILANGES SERUM SENSITIVE GENES 9054All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway