Gene Page: FOXI1
Summary ?
| GeneID | 2299 |
| Symbol | FOXI1 |
| Synonyms | FKH10|FKHL10|FREAC-6|FREAC6|HFH-3|HFH3 |
| Description | forkhead box I1 |
| Reference | MIM:601093|HGNC:HGNC:3815|Ensembl:ENSG00000168269|HPRD:03057|Vega:OTTHUMG00000130436 |
| Gene type | protein-coding |
| Map location | 5q34 |
| Pascal p-value | 0.012 |
| Fetal beta | 0.316 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.0276 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ZNF397 | 0.40 | 0.40 |
| MDN1 | 0.40 | 0.36 |
| CHD2 | 0.40 | 0.39 |
| KIAA1530 | 0.39 | 0.39 |
| ATM | 0.39 | 0.36 |
| MACF1 | 0.39 | 0.40 |
| NIN | 0.38 | 0.41 |
| TNRC6A | 0.38 | 0.39 |
| ZC3H13 | 0.38 | 0.40 |
| GIGYF2 | 0.38 | 0.40 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C1orf122 | -0.29 | -0.33 |
| GCAT | -0.28 | -0.32 |
| COX5B | -0.28 | -0.32 |
| NENF | -0.27 | -0.34 |
| NUDT22 | -0.27 | -0.31 |
| SHISA4 | -0.27 | -0.33 |
| AC018755.9 | -0.27 | -0.28 |
| ENHO | -0.27 | -0.33 |
| ITM2A | -0.27 | -0.29 |
| FAM108A4 | -0.27 | -0.29 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003700 | transcription factor activity | TAS | 7957066 | |
| GO:0008301 | DNA bending activity | NAS | - | |
| GO:0016563 | transcription activator activity | IEA | - | |
| GO:0043565 | sequence-specific DNA binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006350 | transcription | IEA | - | |
| GO:0007605 | sensory perception of sound | IEA | - | |
| GO:0007275 | multicellular organismal development | NAS | 7957066 | |
| GO:0042472 | inner ear morphogenesis | IEA | - | |
| GO:0045893 | positive regulation of transcription, DNA-dependent | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005634 | nucleus | NAS | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| SHEPARD BMYB MORPHOLINO UP | 205 | 126 | All SZGR 2.0 genes in this pathway |
| SU SALIVARY GLAND | 16 | 9 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY LUMINAL PROGENITOR UP | 58 | 30 | All SZGR 2.0 genes in this pathway |