Gene Page: FOXL1
Summary ?
| GeneID | 2300 |
| Symbol | FOXL1 |
| Synonyms | FKH6|FKHL11|FREAC7 |
| Description | forkhead box L1 |
| Reference | MIM:603252|HGNC:HGNC:3817|Ensembl:ENSG00000176678|HPRD:07219|Vega:OTTHUMG00000137653 |
| Gene type | protein-coding |
| Map location | 16q24 |
| Pascal p-value | 0.844 |
| Fetal beta | 0.185 |
| eGene | Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| NOTCH1 | 0.81 | 0.78 |
| PTBP1 | 0.81 | 0.67 |
| NFATC4 | 0.81 | 0.71 |
| EPHB4 | 0.80 | 0.66 |
| AL161668.2 | 0.79 | 0.73 |
| SALL1 | 0.78 | 0.70 |
| TEAD3 | 0.78 | 0.70 |
| SMO | 0.78 | 0.63 |
| KIAA0323 | 0.78 | 0.72 |
| ERBB2 | 0.77 | 0.70 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| TMEM126A | -0.37 | -0.48 |
| USMG5 | -0.36 | -0.50 |
| ZFAND2A | -0.35 | -0.40 |
| SYCP3 | -0.35 | -0.34 |
| COX7B | -0.35 | -0.42 |
| C18orf32 | -0.35 | -0.52 |
| THOC7 | -0.34 | -0.42 |
| MRPS28 | -0.34 | -0.50 |
| LY96 | -0.34 | -0.38 |
| NDUFB9 | -0.34 | -0.40 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| RASHI RESPONSE TO IONIZING RADIATION 4 | 61 | 34 | All SZGR 2.0 genes in this pathway |
| BENPORATH SUZ12 TARGETS | 1038 | 678 | All SZGR 2.0 genes in this pathway |
| BENPORATH EED TARGETS | 1062 | 725 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES WITH H3K27ME3 | 1118 | 744 | All SZGR 2.0 genes in this pathway |
| BENPORATH PRC2 TARGETS | 652 | 441 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3K27ME3 | 79 | 59 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K27ME3 | 269 | 159 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN IPS WITH HCP H3K27ME3 | 102 | 76 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN NPC HCP WITH H3K27ME3 | 341 | 243 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3K27ME3 | 590 | 403 | All SZGR 2.0 genes in this pathway |
| CHICAS RB1 TARGETS CONFLUENT | 567 | 365 | All SZGR 2.0 genes in this pathway |