Gene Page: KLHDC10
Summary ?
| GeneID | 23008 |
| Symbol | KLHDC10 |
| Synonyms | slim |
| Description | kelch domain containing 10 |
| Reference | MIM:615152|HGNC:HGNC:22194|Ensembl:ENSG00000128607|HPRD:17182|Vega:OTTHUMG00000157654 |
| Gene type | protein-coding |
| Map location | 7q32.2 |
| Pascal p-value | 0.031 |
| eGene | Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ATRX | 0.92 | 0.91 |
| AKAP9 | 0.92 | 0.90 |
| SETD2 | 0.92 | 0.87 |
| C6orf174 | 0.91 | 0.86 |
| ZNF605 | 0.90 | 0.87 |
| ZC3H6 | 0.89 | 0.91 |
| BPTF | 0.89 | 0.88 |
| JMJD1C | 0.89 | 0.87 |
| ZNF445 | 0.89 | 0.86 |
| C10orf18 | 0.88 | 0.86 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AIFM3 | -0.69 | -0.75 |
| ALDOC | -0.69 | -0.76 |
| TSC22D4 | -0.68 | -0.77 |
| SNTA1 | -0.68 | -0.80 |
| CLU | -0.67 | -0.74 |
| HSD17B14 | -0.67 | -0.76 |
| RAMP1 | -0.67 | -0.77 |
| HLA-F | -0.66 | -0.73 |
| SERPINB6 | -0.66 | -0.71 |
| HEPN1 | -0.66 | -0.73 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER DN | 169 | 118 | All SZGR 2.0 genes in this pathway |
| HOOI ST7 TARGETS UP | 94 | 57 | All SZGR 2.0 genes in this pathway |
| THUM SYSTOLIC HEART FAILURE DN | 244 | 147 | All SZGR 2.0 genes in this pathway |
| DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP | 368 | 234 | All SZGR 2.0 genes in this pathway |
| BASAKI YBX1 TARGETS DN | 384 | 230 | All SZGR 2.0 genes in this pathway |
| SCIBETTA KDM5B TARGETS UP | 19 | 12 | All SZGR 2.0 genes in this pathway |
| KIM WT1 TARGETS DN | 459 | 276 | All SZGR 2.0 genes in this pathway |
| DACOSTA UV RESPONSE VIA ERCC3 DN | 855 | 609 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT 6HR DN | 514 | 330 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX4 UP | 11 | 8 | All SZGR 2.0 genes in this pathway |
| DELASERNA MYOD TARGETS UP | 89 | 51 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 14HR UP | 156 | 101 | All SZGR 2.0 genes in this pathway |
| DOUGLAS BMI1 TARGETS DN | 314 | 188 | All SZGR 2.0 genes in this pathway |
| WALLACE PROSTATE CANCER RACE DN | 88 | 42 | All SZGR 2.0 genes in this pathway |
| SHEDDEN LUNG CANCER GOOD SURVIVAL A4 | 196 | 124 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 DN | 918 | 550 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |