Gene Page: SPEN
Summary ?
| GeneID | 23013 |
| Symbol | SPEN |
| Synonyms | HIAA0929|MINT|RBM15C|SHARP |
| Description | spen family transcriptional repressor |
| Reference | MIM:613484|HGNC:HGNC:17575|Ensembl:ENSG00000065526|HPRD:10230|Vega:OTTHUMG00000009376 |
| Gene type | protein-coding |
| Map location | 1p36 |
| Pascal p-value | 0.204 |
| Sherlock p-value | 0.23 |
| Fetal beta | 0.94 |
| DMG | 1 (# studies) |
| Support | CompositeSet Darnell FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Nishioka_2013 | Genome-wide DNA methylation analysis | The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg15500658 | 1 | 16174610 | SPEN | -0.024 | 0.55 | DMG:Nishioka_2013 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| WNK1 | 0.87 | 0.89 |
| LAMP1 | 0.86 | 0.85 |
| PHLPP1 | 0.85 | 0.87 |
| HIATL1 | 0.85 | 0.82 |
| ADIPOR2 | 0.85 | 0.81 |
| ARHGEF10 | 0.85 | 0.85 |
| ATP11A | 0.84 | 0.87 |
| CLN8 | 0.84 | 0.86 |
| ABCG1 | 0.84 | 0.87 |
| MPDZ | 0.84 | 0.87 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| FAM159B | -0.52 | -0.55 |
| IL32 | -0.51 | -0.48 |
| AL050337.1 | -0.50 | -0.38 |
| SYCP3 | -0.50 | -0.41 |
| ST20 | -0.49 | -0.51 |
| AF347015.21 | -0.49 | -0.30 |
| RP9P | -0.48 | -0.46 |
| SPDYA | -0.47 | -0.45 |
| C1orf54 | -0.47 | -0.31 |
| AC087071.1 | -0.46 | -0.37 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| DLX5 | - | distal-less homeobox 5 | - | HPRD | 10451362 |
| HDAC1 | DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1 | histone deacetylase 1 | - | HPRD,BioGRID | 11331609 |
| HDAC2 | RPD3 | YAF1 | histone deacetylase 2 | - | HPRD | 11331609 |
| MBD3 | - | methyl-CpG binding domain protein 3 | - | HPRD | 11331609 |
| MSX2 | CRS2 | FPP | HOX8 | MSH | PFM | PFM1 | msh homeobox 2 | - | HPRD | 10451362 |
| MTA2 | DKFZp686F2281 | MTA1L1 | PID | metastasis associated 1 family, member 2 | - | HPRD | 11331609 |
| NCOR1 | KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoR | nuclear receptor co-repressor 1 | - | HPRD | 11331609 |
| NCOR2 | CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1 | nuclear receptor co-repressor 2 | - | HPRD,BioGRID | 11331609 |
| PAK1 | MGC130000 | MGC130001 | PAKalpha | p21 protein (Cdc42/Rac)-activated kinase 1 | Pak1 phosphorylates SHARP. This interaction was modeled on a demonstrated interaction between Pak1 and SHARP both from an unspecified species. | BIND | 15824732 |
| PPARD | FAAR | MGC3931 | NR1C2 | NUC1 | NUCI | NUCII | PPAR-beta | PPARB | peroxisome proliferator-activated receptor delta | - | HPRD,BioGRID | 11867749 |
| RARA | NR1B1 | RAR | retinoic acid receptor, alpha | - | HPRD | 11331609 |
| RBBP4 | NURF55 | RBAP48 | retinoblastoma binding protein 4 | - | HPRD | 11331609 |
| RBPJ | CBF1 | IGKJRB | IGKJRB1 | KBF2 | MGC61669 | RBP-J | RBPJK | RBPSUH | SUH | csl | recombination signal binding protein for immunoglobulin kappa J region | - | HPRD,BioGRID | 12374742 |
| SOX9 | CMD1 | CMPD1 | SRA1 | SRY (sex determining region Y)-box 9 | - | HPRD | 11331609 |
| SRA1 | MGC87674 | SRA | SRAP | STRAA1 | pp7684 | steroid receptor RNA activator 1 | Affinity Capture-Western Reconstituted Complex | BioGRID | 11331609 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BIOCARTA CARM ER PATHWAY | 35 | 27 | All SZGR 2.0 genes in this pathway |
| PID NOTCH PATHWAY | 59 | 49 | All SZGR 2.0 genes in this pathway |
| PID HES HEY PATHWAY | 48 | 39 | All SZGR 2.0 genes in this pathway |
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP | 177 | 110 | All SZGR 2.0 genes in this pathway |
| RODRIGUES NTN1 TARGETS DN | 158 | 102 | All SZGR 2.0 genes in this pathway |
| OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN | 275 | 168 | All SZGR 2.0 genes in this pathway |
| DITTMER PTHLH TARGETS DN | 73 | 51 | All SZGR 2.0 genes in this pathway |
| KIM WT1 TARGETS 8HR UP | 164 | 122 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN | 770 | 415 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| DACOSTA UV RESPONSE VIA ERCC3 DN | 855 | 609 | All SZGR 2.0 genes in this pathway |
| DACOSTA UV RESPONSE VIA ERCC3 COMMON DN | 483 | 336 | All SZGR 2.0 genes in this pathway |
| SAKAI TUMOR INFILTRATING MONOCYTES UP | 27 | 19 | All SZGR 2.0 genes in this pathway |
| FAELT B CLL WITH VH REARRANGEMENTS UP | 48 | 34 | All SZGR 2.0 genes in this pathway |
| FAELT B CLL WITH VH3 21 DN | 49 | 29 | All SZGR 2.0 genes in this pathway |
| GENTILE UV RESPONSE CLUSTER D4 | 55 | 37 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| GENTILE UV HIGH DOSE DN | 312 | 203 | All SZGR 2.0 genes in this pathway |
| DAZARD RESPONSE TO UV NHEK DN | 318 | 220 | All SZGR 2.0 genes in this pathway |
| RAMASWAMY METASTASIS UP | 66 | 43 | All SZGR 2.0 genes in this pathway |
| MITSIADES RESPONSE TO APLIDIN DN | 249 | 165 | All SZGR 2.0 genes in this pathway |
| YAGI AML WITH INV 16 TRANSLOCATION | 422 | 277 | All SZGR 2.0 genes in this pathway |
| CHICAS RB1 TARGETS SENESCENT | 572 | 352 | All SZGR 2.0 genes in this pathway |
| LI DCP2 BOUND MRNA | 89 | 57 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP D | 280 | 158 | All SZGR 2.0 genes in this pathway |
| BILANGES SERUM SENSITIVE GENES | 90 | 54 | All SZGR 2.0 genes in this pathway |
| DELACROIX RAR BOUND ES | 462 | 273 | All SZGR 2.0 genes in this pathway |