Summary ?
GeneID23105
SymbolFSTL4
Synonyms-
Descriptionfollistatin like 4
ReferenceHGNC:HGNC:21389|Ensembl:ENSG00000053108|HPRD:17022|Vega:OTTHUMG00000162729
Gene typeprotein-coding
Map location5q31.1
Pascal p-value0.008
Fetal beta-2.758
eGeneMeta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.0032 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SMEK10.960.98
ZNF280D0.960.96
NOL80.950.96
ZNF6380.950.97
SUV420H10.940.96
CXorf230.940.93
ZNF450.940.95
TTC170.940.96
CHD10.940.96
DHX290.940.96
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.77-0.89
MT-CO2-0.76-0.89
FXYD1-0.75-0.87
AF347015.27-0.74-0.85
IFI27-0.74-0.88
HLA-F-0.74-0.78
AIFM3-0.74-0.78
TSC22D4-0.74-0.81
AF347015.33-0.73-0.84
MT-CYB-0.73-0.85

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005509calcium ion bindingIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K27ME3 7959All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341243All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-346927933m8hsa-miR-346brainUGUCUGCCCGCAUGCCUGCCUCU