Gene Page: SMC5

Summary ?
GeneID23137
SymbolSMC5
SynonymsSMC5L1
Descriptionstructural maintenance of chromosomes 5
ReferenceMIM:609386|HGNC:HGNC:20465|Ensembl:ENSG00000198887|HPRD:10241|Vega:OTTHUMG00000019992
Gene typeprotein-coding
Map location9q21.12
Pascal p-value0.002

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ITGAV0.790.83
IL6ST0.790.86
AHCYL10.760.85
KIAA04940.760.81
ALDH5A10.750.81
NEBL0.740.74
NTRK20.740.80
SASH10.740.73
MFAP3L0.740.69
GPM6B0.740.78
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RP9P-0.44-0.50
BCL7C-0.43-0.50
ACSM3-0.43-0.44
SNHG12-0.43-0.49
ST20-0.43-0.46
FAM159B-0.43-0.49
AC135724.1-0.42-0.40
AC120053.1-0.40-0.44
AC087071.1-0.40-0.42
RPL36-0.40-0.48

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
GAZDA DIAMOND BLACKFAN ANEMIA PROGENITOR DN 6642All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP 408247All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP 177110All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL DN 6039All SZGR 2.0 genes in this pathway
SCIBETTA KDM5B TARGETS DN 8155All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER WITH LOH IN CHR9Q 11671All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855609All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483336All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424268All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION DN 169112All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH3 21 DN 4929All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL 254164All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262186All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318220All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G6 153112All SZGR 2.0 genes in this pathway
ZHENG FOXP3 TARGETS IN THYMUS UP 196137All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374247All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518299All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN 18197All SZGR 2.0 genes in this pathway
GABRIELY MIR21 TARGETS 289187All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279155All SZGR 2.0 genes in this pathway
GHANDHI DIRECT IRRADIATION UP 11068All SZGR 2.0 genes in this pathway