Gene Page: FLII
Summary ?
| GeneID | 2314 |
| Symbol | FLII |
| Synonyms | FLI|FLIL|Fli1 |
| Description | flightless I actin binding protein |
| Reference | MIM:600362|HGNC:HGNC:3750|Ensembl:ENSG00000177731|HPRD:02647|Vega:OTTHUMG00000059389 |
| Gene type | protein-coding |
| Map location | 17p11.2 |
| Pascal p-value | 0.013 |
| Sherlock p-value | 0.965 |
| eGene | Cerebellum Meta |
| Support | Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CALCOCO2 | 0.77 | 0.71 |
| ATP13A4 | 0.74 | 0.66 |
| KAT2B | 0.74 | 0.68 |
| SSFA2 | 0.74 | 0.70 |
| ADD3 | 0.73 | 0.65 |
| GRAMD3 | 0.73 | 0.65 |
| ALDH6A1 | 0.73 | 0.66 |
| PMP2 | 0.72 | 0.64 |
| BMPR1B | 0.72 | 0.62 |
| CDC14B | 0.71 | 0.68 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MED19 | -0.44 | -0.46 |
| TUBB3 | -0.43 | -0.39 |
| C3orf54 | -0.42 | -0.40 |
| TUBB | -0.42 | -0.39 |
| IGFBP2 | -0.41 | -0.38 |
| PAFAH1B3 | -0.41 | -0.42 |
| AKR1C1 | -0.41 | -0.36 |
| VPS37D | -0.41 | -0.39 |
| DCTPP1 | -0.41 | -0.41 |
| GDAP1L1 | -0.41 | -0.38 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PARENT MTOR SIGNALING UP | 567 | 375 | All SZGR 2.0 genes in this pathway |
| HOLLMANN APOPTOSIS VIA CD40 UP | 201 | 125 | All SZGR 2.0 genes in this pathway |
| GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN | 493 | 298 | All SZGR 2.0 genes in this pathway |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| DELYS THYROID CANCER UP | 443 | 294 | All SZGR 2.0 genes in this pathway |
| OUELLET CULTURED OVARIAN CANCER INVASIVE VS LMP UP | 69 | 40 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER UP | 181 | 108 | All SZGR 2.0 genes in this pathway |
| THEILGAARD NEUTROPHIL AT SKIN WOUND DN | 225 | 163 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE INCIPIENT UP | 390 | 242 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| KAAB HEART ATRIUM VS VENTRICLE DN | 261 | 183 | All SZGR 2.0 genes in this pathway |
| CAMPS COLON CANCER COPY NUMBER UP | 92 | 45 | All SZGR 2.0 genes in this pathway |
| HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP | 163 | 102 | All SZGR 2.0 genes in this pathway |
| HOFFMANN SMALL PRE BII TO IMMATURE B LYMPHOCYTE UP | 70 | 49 | All SZGR 2.0 genes in this pathway |
| LI DCP2 BOUND MRNA | 89 | 57 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 UP | 430 | 288 | All SZGR 2.0 genes in this pathway |
| VANOEVELEN MYOGENESIS SIN3A TARGETS | 220 | 133 | All SZGR 2.0 genes in this pathway |