SZGR2

Summary ?

GeneID	23162
Symbol	MAPK8IP3
Synonyms	JIP-3\|JIP3\|JSAP1\|SYD2\|syd
Description	mitogen-activated protein kinase 8 interacting protein 3
Reference	MIM:605431\|HGNC:HGNC:6884\|Ensembl:ENSG00000138834\|HPRD:12014\|Vega:OTTHUMG00000128637
Gene type	protein-coding
Map location	16p13.3
Pascal p-value	0.067
Sherlock p-value	0.01
Fetal beta	-0.632
DMG	1 (# studies)
Support	INTRACELLULAR SIGNAL TRANSDUCTION CompositeSet Darnell FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	2

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg02994291	16	1782905	MAPK8IP3	1.125E-4	0.455	0.029	DMG:Wockner_2014
cg07058132	16	1755945	MAPK8IP3	2.811E-4	-0.256	0.039	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ARL4D	ARF4L \| ARL6	ADP-ribosylation factor-like 4D	Two-hybrid	BioGRID	16169070
KLC1	KLC \| KNS2 \| KNS2A \| MGC15245	kinesin light chain 1	-	HPRD,BioGRID	11106729
KLC2	FLJ12387	kinesin light chain 2	-	HPRD,BioGRID	11106729
MAP2K1	MAPKK1 \| MEK1 \| MKK1 \| PRKMK1	mitogen-activated protein kinase kinase 1	-	HPRD,BioGRID	10523642 \|11044439
MAP2K4	JNKK \| JNKK1 \| MAPKK4 \| MEK4 \| MKK4 \| PRKMK4 \| SEK1 \| SERK1	mitogen-activated protein kinase kinase 4	-	HPRD,BioGRID	10523642 \|12189133
MAP2K4	JNKK \| JNKK1 \| MAPKK4 \| MEK4 \| MKK4 \| PRKMK4 \| SEK1 \| SERK1	mitogen-activated protein kinase kinase 4	-	HPRD	12189133
MAP2K7	Jnkk2 \| MAPKK7 \| MKK7 \| PRKMK7	mitogen-activated protein kinase kinase 7	-	HPRD,BioGRID	10629060 \|12189133
MAP3K1	MAPKKK1 \| MEKK \| MEKK1	mitogen-activated protein kinase kinase kinase 1	Affinity Capture-Western	BioGRID	10523642
MAP3K11	MGC17114 \| MLK-3 \| MLK3 \| PTK1 \| SPRK	mitogen-activated protein kinase kinase kinase 11	-	HPRD,BioGRID	10629060
MAP3K5	ASK1 \| MAPKKK5 \| MEKK5	mitogen-activated protein kinase kinase kinase 5	-	HPRD,BioGRID	12189133
MAPK10	FLJ12099 \| FLJ33785 \| JNK3 \| JNK3A \| MGC50974 \| PRKM10 \| p493F12 \| p54bSAPK	mitogen-activated protein kinase 10	-	HPRD,BioGRID	10523642 \|10629060 \|12189133
MAPK8	JNK \| JNK1 \| JNK1A2 \| JNK21B1/2 \| PRKM8 \| SAPK1	mitogen-activated protein kinase 8	-	HPRD,BioGRID	10523642 \|10629060 \|12189133
MAPK8IP1	IB1 \| JIP-1 \| JIP1 \| PRKM8IP	mitogen-activated protein kinase 8 interacting protein 1	-	HPRD,BioGRID	10629060
MAPK8IP2	IB2 \| JIP2 \| PRKM8IPL	mitogen-activated protein kinase 8 interacting protein 2	-	HPRD,BioGRID	10629060
MAPK9	JNK-55 \| JNK2 \| JNK2A \| JNK2ALPHA \| JNK2B \| JNK2BETA \| PRKM9 \| SAPK \| p54a \| p54aSAPK	mitogen-activated protein kinase 9	-	HPRD,BioGRID	10523642 \|10629060 \|12189133
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	Affinity Capture-Western	BioGRID	12226752
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	-	HPRD,BioGRID	10523642 \|11044439
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	-	HPRD	11044439
RIC8A	MGC104517 \| MGC131931 \| MGC148073 \| MGC148074 \| RIC8 \| synembryn	resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)	Two-hybrid	BioGRID	16169070
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Biochemical Activity	BioGRID	12226752

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
ST DIFFERENTIATION PATHWAY IN PC12 CELLS	45	35	All SZGR 2.0 genes in this pathway
SA B CELL RECEPTOR COMPLEXES	24	20	All SZGR 2.0 genes in this pathway
SIG CD40PATHWAYMAP	34	28	All SZGR 2.0 genes in this pathway
ST GRANULE CELL SURVIVAL PATHWAY	27	23	All SZGR 2.0 genes in this pathway
ST INTEGRIN SIGNALING PATHWAY	82	62	All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY	65	54	All SZGR 2.0 genes in this pathway
PID ARF6 TRAFFICKING PATHWAY	49	34	All SZGR 2.0 genes in this pathway
PID FAK PATHWAY	59	45	All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN	335	193	All SZGR 2.0 genes in this pathway
SCIBETTA KDM5B TARGETS UP	19	12	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN	234	147	All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER DN	185	115	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW DN	165	107	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH DN	180	110	All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA DN	181	107	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 3	48	31	All SZGR 2.0 genes in this pathway
WANG HCP PROSTATE CANCER	111	69	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 16P13 AMPLICON	120	49	All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1	419	273	All SZGR 2.0 genes in this pathway
OUYANG PROSTATE CANCER PROGRESSION DN	21	16	All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING	510	309	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
HOFFMANN PRE BI TO LARGE PRE BII LYMPHOCYTE DN	75	61	All SZGR 2.0 genes in this pathway
HOFFMANN SMALL PRE BII TO IMMATURE B LYMPHOCYTE UP	70	49	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR UP	221	150	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN	457	302	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A	770	480	All SZGR 2.0 genes in this pathway

Gene Page: MAPK8IP3