Gene Page: KIAA0556
Summary ?
| GeneID | 23247 |
| Symbol | KIAA0556 |
| Synonyms | JBTS26 |
| Description | KIAA0556 |
| Reference | MIM:616650|HGNC:HGNC:29068|Ensembl:ENSG00000047578|HPRD:13806|Vega:OTTHUMG00000176780 |
| Gene type | protein-coding |
| Map location | 16p12.1 |
| Pascal p-value | 0.016 |
| Sherlock p-value | 0.521 |
| Fetal beta | -0.026 |
| DMG | 1 (# studies) |
| Support | Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 2 |
| GSMA_IIE | Genome scan meta-analysis (European-ancestry samples) | Psr: 0.01775 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg07025312 | 16 | 27583843 | KIAA0556 | 1.727E-4 | -0.576 | 0.033 | DMG:Wockner_2014 |
| cg02314514 | 16 | 27786318 | KIAA0556 | 4.512E-4 | 0.328 | 0.045 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ZBTB7A | 0.94 | 0.93 |
| PHF15 | 0.94 | 0.91 |
| TEF | 0.93 | 0.90 |
| HLF | 0.92 | 0.89 |
| HABP4 | 0.91 | 0.89 |
| ZNF365 | 0.90 | 0.82 |
| MBNL2 | 0.90 | 0.85 |
| PPP1R16B | 0.90 | 0.82 |
| IQSEC1 | 0.90 | 0.79 |
| SYNPO | 0.90 | 0.89 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| BCL7C | -0.59 | -0.73 |
| C9orf46 | -0.57 | -0.74 |
| TUBB2B | -0.57 | -0.65 |
| TRAF4 | -0.57 | -0.70 |
| DYNLT1 | -0.56 | -0.79 |
| KIAA1949 | -0.56 | -0.54 |
| EXOSC8 | -0.55 | -0.68 |
| RPL23A | -0.55 | -0.71 |
| YBX1 | -0.55 | -0.62 |
| GTF3C6 | -0.54 | -0.62 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005179 | hormone activity | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005576 | extracellular region | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PARENT MTOR SIGNALING UP | 567 | 375 | All SZGR 2.0 genes in this pathway |
| DAVICIONI MOLECULAR ARMS VS ERMS UP | 332 | 228 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS BASAL UP | 380 | 215 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP | 450 | 256 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| WEI MYCN TARGETS WITH E BOX | 795 | 478 | All SZGR 2.0 genes in this pathway |
| LEE TARGETS OF PTCH1 AND SUFU UP | 53 | 37 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER UP | 973 | 570 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | 863 | 514 | All SZGR 2.0 genes in this pathway |
| GRADE COLON CANCER UP | 871 | 505 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 3 UP | 170 | 97 | All SZGR 2.0 genes in this pathway |
| FOSTER KDM1A TARGETS DN | 211 | 119 | All SZGR 2.0 genes in this pathway |