Gene Page: ZC3H7B
Summary ?
| GeneID | 23264 |
| Symbol | ZC3H7B |
| Synonyms | RoXaN |
| Description | zinc finger CCCH-type containing 7B |
| Reference | HGNC:HGNC:30869|Ensembl:ENSG00000100403|HPRD:06711|Vega:OTTHUMG00000150969 |
| Gene type | protein-coding |
| Map location | 22q13.2 |
| Pascal p-value | 1.881E-4 |
| Fetal beta | 0.335 |
| DMG | 1 (# studies) |
| Support | CompositeSet Darnell FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg05508875 | 22 | 41697415 | ZC3H7B | 3.46E-10 | -0.018 | 7.22E-7 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SEC61A1 | 0.91 | 0.90 |
| SEPN1 | 0.91 | 0.87 |
| ANKFY1 | 0.91 | 0.89 |
| ZXDC | 0.90 | 0.90 |
| DAG1 | 0.90 | 0.90 |
| ACOX1 | 0.90 | 0.89 |
| HEATR6 | 0.90 | 0.88 |
| C10orf26 | 0.90 | 0.90 |
| VEZF1 | 0.90 | 0.87 |
| MTMR3 | 0.90 | 0.90 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.66 | -0.78 |
| C5orf53 | -0.65 | -0.70 |
| AF347015.31 | -0.65 | -0.76 |
| AF347015.27 | -0.64 | -0.75 |
| AF347015.33 | -0.63 | -0.73 |
| AF347015.8 | -0.63 | -0.76 |
| AF347015.21 | -0.62 | -0.81 |
| MT-CYB | -0.62 | -0.73 |
| FXYD1 | -0.61 | -0.70 |
| S100B | -0.60 | -0.68 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ZHOU INFLAMMATORY RESPONSE LIVE UP | 485 | 293 | All SZGR 2.0 genes in this pathway |
| GAL LEUKEMIC STEM CELL UP | 133 | 78 | All SZGR 2.0 genes in this pathway |
| GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN | 335 | 193 | All SZGR 2.0 genes in this pathway |
| LIU COMMON CANCER GENES | 79 | 47 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE INCIPIENT UP | 390 | 242 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| SPIRA SMOKERS LUNG CANCER DN | 22 | 11 | All SZGR 2.0 genes in this pathway |
| LEE DIFFERENTIATING T LYMPHOCYTE | 200 | 115 | All SZGR 2.0 genes in this pathway |