Gene Page: ACSL6

Summary
GeneID  23305
Symbol  ACSL6
Synonyms  ACS2|FACL6|FLJ16173|KIAA0837|LACS2|LACS5
Description  acyl-CoA synthetase long-chain family member 6
See related  HGNC:16496|MIM:604443|Ensembl:ENSG00000164398|HPRD:09190|
Locus tag  -
Gene type  protein-coding
Map location  5q31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.0032 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PDE1B0.950.91
AC005512.10.950.67
ADORA2A0.930.05
WNT60.920.56
LINGO30.920.77
TMEM90A0.900.61
RGS90.900.24
PENK0.900.43
PTPN70.890.21
RGS140.890.74
Top 10 negatively co-expressed genes
ZNF435-0.22-0.30
TUBB2B-0.22-0.42
STMN1-0.22-0.13
KIAA1949-0.22-0.30
CBS-0.21-0.29
BLVRA-0.21-0.10
CCDC90A-0.21-0.27
IGFBP2-0.21-0.31
RPL38-0.21-0.60
DYNLT1-0.21-0.51
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000287magnesium ion bindingIEA-
GO:0003824catalytic activityIEA-
GO:0004467long-chain-fatty-acid-CoA ligase activityNAS10548543 
GO:0016874ligase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008152metabolic processIEA-
GO:0006637acyl-CoA metabolic processNAS10548543 
GO:0006629lipid metabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005792microsomeNAS-
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005739mitochondrionIEA-
GO:0005741mitochondrial outer membraneNAS-
GO:0005777peroxisomeIEA-
GO:0005778peroxisomal membraneNAS-
GO:0005783endoplasmic reticulumIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneNAS10548543 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_FATTY_ACID_METABOLISM 4229All SZGR genes in this pathway
KEGG_PPAR_SIGNALING_PATHWAY 6947All SZGR genes in this pathway
KEGG_PEROXISOME 7847All SZGR genes in this pathway
KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 6757All SZGR genes in this pathway
REACTOME_TRIGLYCERIDE_BIOSYNTHESIS 3826All SZGR genes in this pathway
REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS 1815All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 168115All SZGR genes in this pathway
REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS 1412All SZGR genes in this pathway
WATANABE_COLON_CANCER_MSI_VS_MSS_DN 8142All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_DN 14290All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_UP 14175All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_DN 226132All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_27 158All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002 429260All SZGR genes in this pathway
LEE_LIVER_CANCER_SURVIVAL_UP 185112All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G6_UP 6543All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_UP 176110All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
TERAO_AOX4_TARGETS_HG_UP 2820All SZGR genes in this pathway
TERAO_AOX4_TARGETS_SKIN_DN 2715All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/984004071A,m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-13739451Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-196399405m8hsa-miR-196aUAGGUAGUUUCAUGUUGUUGG
hsa-miR-196bUAGGUAGUUUCCUGUUGUUGG
miR-24*3873931Ahsa-miR-189GUGCCUACUGAGCUGAUAUCAGU
miR-4962362421Ahsa-miR-496AUUACAUGGCCAAUCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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