SZGR2

Summary ?

GeneID	2335
Symbol	FN1
Synonyms	CIG\|ED-B\|FINC\|FN\|FNZ\|GFND\|GFND2\|LETS\|MSF
Description	fibronectin 1
Reference	MIM:135600\|HGNC:HGNC:3778\|Ensembl:ENSG00000115414\|HPRD:00626\|Vega:OTTHUMG00000133054
Gene type	protein-coding
Map location	2q34
Pascal p-value	0.558
Sherlock p-value	0.423
Fetal beta	1.153
eGene	Myers' cis & trans
Support	CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DNM:Fromer_2014	Whole Exome Sequencing analysis	This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
DNM:Guipponi_2014	Whole Exome Sequencing analysis	49 DNMs were identified by comparing the exome of 53 individuals with sporadic SCZ and of their non-affected parents
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIE	Genome scan meta-analysis (European-ancestry samples)	Psr: 0.01016
GSMA_IIA	Genome scan meta-analysis (All samples)	Psr: 0.00916
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

DNM table

Gene	Chromosome	Position	Ref	Alt	Transcript	AA change	Mutation type	Sift	CG46	Trait	Study
FN1	chr2	216262472	C	T	NM_002026 NM_212474 NM_212476 NM_212478 NM_212482	p.1150V>I p.1150V>I p.1150V>I p.1150V>I p.1150V>I	missense missense missense missense missense			Schizophrenia	DNM:Fromer_2014
FN1			G	.	NM_002026	p.A93LfsX26	frameshift	NA	NA	Schizophrenia	DNM:Guipponi_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs4673840	chr2	215363240	FN1	2335	0.18	cis
rs4236095	chr6	47368686	FN1	2335	0.1	trans
rs11002520	chr10	80117056	FN1	2335	0.2	trans
rs11002521	chr10	80118300	FN1	2335	0.09	trans
rs1159612	chr10	85329057	FN1	2335	0	trans
rs11820030	chr11	76133564	FN1	2335	0.12	trans
rs6095741	chr20	48666589	FN1	2335	0.15	trans
rs2838712	chr21	46277775	FN1	2335	0.14	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005518	collagen binding	NAS		3024962
GO:0005201	extracellular matrix structural constituent	NAS		-
GO:0008201	heparin binding	NAS		10075919
GO:0016491	oxidoreductase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	NAS		15609325
GO:0007155	cell adhesion	NAS		1423622
GO:0009611	response to wounding	NAS		7989369
GO:0008152	metabolic process	IEA		-
GO:0006953	acute-phase response	IEA		-
GO:0016477	cell migration	NAS		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005793	ER-Golgi intermediate compartment	IDA		15308636
GO:0005576	extracellular region	EXP		444675
GO:0005576	extracellular region	IEA		-
GO:0005576	extracellular region	NAS		14718574
GO:0005578	proteinaceous extracellular matrix	NAS		-
GO:0031093	platelet alpha granule lumen	EXP		444675

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AMBP	EDC1 \| HCP \| HI30 \| IATIL \| ITI \| ITIL \| ITILC \| UTI	alpha-1-microglobulin/bikunin precursor	-	HPRD,BioGRID	7519849
APCS	MGC88159 \| PTX2 \| SAP	amyloid P component, serum	-	HPRD,BioGRID	12100475
C1QA	-	complement component 1, q subcomponent, A chain	-	HPRD,BioGRID	6981115
CD44	CDW44 \| CSPG8 \| ECMR-III \| HCELL \| IN \| LHR \| MC56 \| MDU2 \| MDU3 \| MGC10468 \| MIC4 \| MUTCH-I \| Pgp1	CD44 molecule (Indian blood group)	Affinity Capture-Western Reconstituted Complex	BioGRID	1730778
COL13A1	COLXIIIA1 \| FLJ42485	collagen, type XIII, alpha 1	-	HPRD,BioGRID	11956183
COL1A1	OI4	collagen, type I, alpha 1	-	HPRD,BioGRID	8468356
COL1A2	OI4	collagen, type I, alpha 2	-	HPRD,BioGRID	8468356
COL2A1	ANFH \| AOM \| COL11A3 \| MGC131516 \| SEDC	collagen, type II, alpha 1	-	HPRD,BioGRID	2229073 \|3997552
COL4A1	arresten	collagen, type IV, alpha 1	-	HPRD	3997552
COL4A2	DKFZp686I14213 \| FLJ22259	collagen, type IV, alpha 2	-	HPRD	3997552
COL4A3	-	collagen, type IV, alpha 3 (Goodpasture antigen)	-	HPRD	3997552
COL4A4	CA44	collagen, type IV, alpha 4	-	HPRD	3997552
COL4A5	ASLN \| ATS \| CA54 \| MGC167109 \| MGC42377	collagen, type IV, alpha 5	-	HPRD	3997552
COL4A6	MGC88184	collagen, type IV, alpha 6	-	HPRD	3997552
COL7A1	EBD1 \| EBDCT \| EBR1	collagen, type VII, alpha 1	-	HPRD,BioGRID	7963647 \|9169408
CRP	MGC149895 \| MGC88244 \| PTX1	C-reactive protein, pentraxin-related	-	HPRD,BioGRID	6693419
CTSD	CLN10 \| CPSD \| MGC2311	cathepsin D	-	HPRD	3988746
CXCL12	PBSF \| SCYB12 \| SDF-1a \| SDF-1b \| SDF1 \| SDF1A \| SDF1B \| TLSF-a \| TLSF-b \| TPAR1	chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)	-	HPRD,BioGRID	11023498
DCN	CSCD \| DSPG2 \| PG40 \| PGII \| PGS2 \| SLRR1B	decorin	-	HPRD	1468447
F13A1	F13A	coagulation factor XIII, A1 polypeptide	-	HPRD,BioGRID	8905624
FASLG	APT1LG1 \| CD178 \| CD95L \| FASL \| TNFSF6	Fas ligand (TNF superfamily, member 6)	-	HPRD,BioGRID	11276204
FBLN1	FBLN	fibulin 1	-	HPRD,BioGRID	1400330
FBLN2	-	fibulin 2	-	HPRD	10848816
GSN	DKFZp313L0718	gelsolin (amyloidosis, Finnish type)	-	HPRD,BioGRID	6092370
HSPG2	PLC \| PRCAN \| SJA \| SJS \| SJS1	heparan sulfate proteoglycan 2	Reconstituted Complex	BioGRID	11493006
IGFBP3	BP-53 \| IBP3	insulin-like growth factor binding protein 3	-	HPRD,BioGRID	11344214
ITGA3	CD49C \| FLJ34631 \| FLJ34704 \| GAP-B3 \| GAPB3 \| MSK18 \| VCA-2 \| VL3A \| VLA3a	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	-	HPRD	9733622
ITGA4	CD49D \| IA4 \| MGC90518	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	-	HPRD	9117345 \|11010812
ITGA5	CD49e \| FNRA \| VLA5A	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	Reconstituted Complex	BioGRID	1532572
ITGA5	CD49e \| FNRA \| VLA5A	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	-	HPRD	9211865 \|11801679
ITGA8	-	integrin, alpha 8	-	HPRD	7559467
ITGB6	-	integrin, beta 6	-	HPRD,BioGRID	1532572 \|8120056
ITGB7	-	integrin, beta 7	-	HPRD,BioGRID	1372909
KLK3	APS \| KLK2A1 \| PSA \| hK3	kallikrein-related peptidase 3	-	HPRD	9016396
LACRT	MGC71934	lacritin	-	HPRD,BioGRID	11419941
LGALS3BP	90K \| BTBD17B \| MAC-2-BP	lectin, galactoside-binding, soluble, 3 binding protein	-	HPRD	9501082
LPA	AK38 \| APOA \| LP	lipoprotein, Lp(a)	-	HPRD,BioGRID	2531657
LRG1	HMFT1766 \| LRG	leucine-rich alpha-2-glycoprotein 1	-	HPRD	11801638
LTBP1	MGC163161	latent transforming growth factor beta binding protein 1	-	HPRD	8756760
MAG	GMA \| S-MAG \| SIGLEC-4A \| SIGLEC4A	myelin associated glycoprotein	-	HPRD	11423128
MATN2	-	matrilin 2	-	HPRD	12180907
MEP1A	PPHA	meprin A, alpha (PABA peptide hydrolase)	-	HPRD,BioGRID	8063866
MEP1B	-	meprin A, beta	-	HPRD,BioGRID	8063866
MIA	CD-RAP	melanoma inhibitory activity	-	HPRD,BioGRID	11157741
MMP9	CLG4B \| GELB \| MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	-	HPRD	11134254
MYOC	GLC1A \| GPOA \| JOAG \| JOAG1 \| TIGR \| myocilin	myocilin, trabecular meshwork inducible glucocorticoid response	-	HPRD,BioGRID	11773026
NOV	CCN3 \| IGFBP9	nephroblastoma overexpressed gene	-	HPRD,BioGRID	12902636
PKD1	PBP	polycystic kidney disease 1 (autosomal dominant)	-	HPRD,BioGRID	11752017
PRELP	MGC45323 \| MST161 \| MSTP161 \| SLRR2A	proline/arginine-rich end leucine-rich repeat protein	-	HPRD	11847210
REG3A	HIP \| INGAP \| PAP \| PAP-H \| PAP1 \| PBCGF \| REG-III \| REG3	regenerating islet-derived 3 alpha	-	HPRD,BioGRID	8997243
SCGB1A1	CC10 \| CC16 \| CCSP \| UGB	secretoglobin, family 1A, member 1 (uteroglobin)	-	HPRD	10470078
SDC2	HSPG \| HSPG1 \| SYND2	syndecan 2	-	HPRD,BioGRID	10772816
SFRP2	FRP-2 \| SARP1 \| SDF-5	secreted frizzled-related protein 2	SFRP2 interacts with an unspecified isoform of FN1 (FN). This interaction was modeled on a demonstrated interaction between canine SFRP2 and human FN1.	BIND	14709558
TAC1	Hs.2563 \| NK2 \| NKNA \| NPK \| TAC2	tachykinin, precursor 1	-	HPRD	11342427
TGFBI	BIGH3 \| CDB1 \| CDG2 \| CDGG1 \| CSD \| CSD1 \| CSD2 \| CSD3 \| EBMD \| LCD1	transforming growth factor, beta-induced, 68kDa	-	HPRD,BioGRID	11867580 \|12034705
TGM2	G-ALPHA-h \| GNAH \| TG2 \| TGC	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	-	HPRD,BioGRID	11686302 \|11829448
THBS1	THBS \| TSP \| TSP1	thrombospondin 1	-	HPRD	11773026
TMPRSS6	IRIDA	transmembrane protease, serine 6	-	HPRD,BioGRID	12149247
TNC	HXB \| MGC167029 \| TN	tenascin C	-	HPRD,BioGRID	7499434
TSHR	CHNG1 \| LGR3 \| MGC75129 \| hTSHR-I	thyroid stimulating hormone receptor	-	HPRD,BioGRID	11981027
VHL	HRCA1 \| RCA1 \| VHL1	von Hippel-Lindau tumor suppressor	pVHL interacts with fibronectin 1	BIND	10823831
VHL	HRCA1 \| RCA1 \| VHL1	von Hippel-Lindau tumor suppressor	-	HPRD,BioGRID	9651579

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG FOCAL ADHESION	201	138	All SZGR 2.0 genes in this pathway
KEGG ECM RECEPTOR INTERACTION	84	53	All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON	216	144	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER	84	67	All SZGR 2.0 genes in this pathway
PID INTEGRIN1 PATHWAY	66	44	All SZGR 2.0 genes in this pathway
PID INTEGRIN3 PATHWAY	43	25	All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY	50	41	All SZGR 2.0 genes in this pathway
PID INTEGRIN A9B1 PATHWAY	25	18	All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY	75	53	All SZGR 2.0 genes in this pathway
PID SYNDECAN 4 PATHWAY	32	25	All SZGR 2.0 genes in this pathway
PID UPA UPAR PATHWAY	42	30	All SZGR 2.0 genes in this pathway
PID INTEGRIN5 PATHWAY	17	9	All SZGR 2.0 genes in this pathway
PID SYNDECAN 2 PATHWAY	33	27	All SZGR 2.0 genes in this pathway
PID LYMPH ANGIOGENESIS PATHWAY	25	16	All SZGR 2.0 genes in this pathway
PID INTEGRIN A4B1 PATHWAY	33	24	All SZGR 2.0 genes in this pathway
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	91	65	All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	89	56	All SZGR 2.0 genes in this pathway
REACTOME INTEGRIN CELL SURFACE INTERACTIONS	79	48	All SZGR 2.0 genes in this pathway
REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	15	11	All SZGR 2.0 genes in this pathway
REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	15	10	All SZGR 2.0 genes in this pathway
REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	27	17	All SZGR 2.0 genes in this pathway
REACTOME PLATELET AGGREGATION PLUG FORMATION	36	23	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP	567	375	All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP	285	181	All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA UP	205	140	All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP	351	230	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP	294	178	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL UP	44	25	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS LOBULAR NORMAL UP	73	50	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS DUCTAL NORMAL UP	69	38	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL DN	74	42	All SZGR 2.0 genes in this pathway
WILCOX RESPONSE TO PROGESTERONE DN	66	44	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP	579	346	All SZGR 2.0 genes in this pathway
SAMOLS TARGETS OF KHSV MIRNAS DN	62	35	All SZGR 2.0 genes in this pathway
HOOI ST7 TARGETS DN	123	78	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP	368	234	All SZGR 2.0 genes in this pathway
RODRIGUES NTN1 TARGETS DN	158	102	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER ADVANCED VS EARLY UP	175	120	All SZGR 2.0 genes in this pathway
JAEGER METASTASIS UP	44	23	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP	194	122	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D UP	175	108	All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP	457	269	All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP	238	144	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN	329	219	All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN	291	176	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA DN	77	52	All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP	443	294	All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID UP	45	26	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN	394	258	All SZGR 2.0 genes in this pathway
WANG ESOPHAGUS CANCER VS NORMAL UP	121	72	All SZGR 2.0 genes in this pathway
JOHANSSON GLIOMAGENESIS BY PDGFB UP	58	44	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 3 4WK UP	214	144	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK UP	271	175	All SZGR 2.0 genes in this pathway
VETTER TARGETS OF PRKCA AND ETS1 UP	16	8	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS UP	169	127	All SZGR 2.0 genes in this pathway
BEGUM TARGETS OF PAX3 FOXO1 FUSION AND PAX3	7	5	All SZGR 2.0 genes in this pathway
TSUNODA CISPLATIN RESISTANCE DN	51	38	All SZGR 2.0 genes in this pathway
WANG HCP PROSTATE CANCER	111	69	All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP	358	245	All SZGR 2.0 genes in this pathway
SIMBULAN UV RESPONSE IMMORTALIZED DN	31	26	All SZGR 2.0 genes in this pathway
KIM MYCN AMPLIFICATION TARGETS DN	103	59	All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION	149	101	All SZGR 2.0 genes in this pathway
KARAKAS TGFB1 SIGNALING	18	15	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN	637	377	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
GUENTHER GROWTH SPHERICAL VS ADHERENT DN	26	19	All SZGR 2.0 genes in this pathway
GOUYER TATI TARGETS DN	17	12	All SZGR 2.0 genes in this pathway
FRIDMAN SENESCENCE UP	77	60	All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN	411	249	All SZGR 2.0 genes in this pathway
WU CELL MIGRATION	184	114	All SZGR 2.0 genes in this pathway
COLIN PILOCYTIC ASTROCYTOMA VS GLIOBLASTOMA DN	28	21	All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION UP	69	55	All SZGR 2.0 genes in this pathway
PETRETTO CARDIAC HYPERTROPHY	34	26	All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 60 MCF10A	57	42	All SZGR 2.0 genes in this pathway
WANG PROSTATE CANCER ANDROGEN INDEPENDENT	66	37	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 UP	256	159	All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS SUBSET	33	20	All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS UP	266	171	All SZGR 2.0 genes in this pathway
NELSON RESPONSE TO ANDROGEN DN	19	14	All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT UP	197	110	All SZGR 2.0 genes in this pathway
IIZUKA LIVER CANCER PROGRESSION L0 L1 UP	17	12	All SZGR 2.0 genes in this pathway
CHANG POU5F1 TARGETS UP	15	10	All SZGR 2.0 genes in this pathway
KENNY CTNNB1 TARGETS DN	52	34	All SZGR 2.0 genes in this pathway
GILDEA METASTASIS	30	14	All SZGR 2.0 genes in this pathway
LEI MYB TARGETS	318	215	All SZGR 2.0 genes in this pathway
YAO HOXA10 TARGETS VIA PROGESTERONE DN	19	12	All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN	408	274	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS NEONATAL	35	25	All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH DN	58	43	All SZGR 2.0 genes in this pathway
LINDVALL IMMORTALIZED BY TERT DN	80	56	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN	504	323	All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C2	25	18	All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS DN	64	44	All SZGR 2.0 genes in this pathway
VERRECCHIA EARLY RESPONSE TO TGFB1	58	43	All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD UP	222	139	All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP	487	303	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP	428	266	All SZGR 2.0 genes in this pathway
KAYO CALORIE RESTRICTION MUSCLE UP	95	64	All SZGR 2.0 genes in this pathway
JIANG HYPOXIA CANCER	83	52	All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP	280	183	All SZGR 2.0 genes in this pathway
URS ADIPOCYTE DIFFERENTIATION DN	30	20	All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE	261	166	All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP	566	371	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND MACROPHAGE	77	50	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM	66	47	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST	132	93	All SZGR 2.0 genes in this pathway
JI CARCINOGENESIS BY KRAS AND STK11 DN	17	12	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN	195	135	All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE UP	56	41	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP	317	208	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP	461	298	All SZGR 2.0 genes in this pathway
DE YY1 TARGETS DN	92	64	All SZGR 2.0 genes in this pathway
OUYANG PROSTATE CANCER MARKERS	19	16	All SZGR 2.0 genes in this pathway
ENGELMANN CANCER PROGENITORS DN	70	44	All SZGR 2.0 genes in this pathway
HUANG FOXA2 TARGETS UP	45	28	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP	425	298	All SZGR 2.0 genes in this pathway
BRUECKNER TARGETS OF MIRLET7A3 DN	78	49	All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE	242	168	All SZGR 2.0 genes in this pathway
CROMER TUMORIGENESIS UP	63	36	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP	374	247	All SZGR 2.0 genes in this pathway
GU PDEF TARGETS UP	71	49	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN	366	257	All SZGR 2.0 genes in this pathway
VANASSE BCL2 TARGETS DN	74	50	All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS KERATINOCYTE UP	91	63	All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS FIBROBLAST UP	84	60	All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP	395	249	All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN	457	302	All SZGR 2.0 genes in this pathway
LIU VAV3 PROSTATE CARCINOGENESIS UP	89	61	All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE UP	181	106	All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP	288	168	All SZGR 2.0 genes in this pathway
SCHOEN NFKB SIGNALING	34	26	All SZGR 2.0 genes in this pathway
KESHELAVA MULTIPLE DRUG RESISTANCE	88	56	All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2	277	172	All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN	222	141	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP	221	135	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT	567	365	All SZGR 2.0 genes in this pathway
QI HYPOXIA TARGETS OF HIF1A AND FOXA2	37	27	All SZGR 2.0 genes in this pathway
HOELZEL NF1 TARGETS DN	115	73	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN	505	328	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP	504	321	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP	430	288	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
ZHU SKIL TARGETS UP	20	14	All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN	315	215	All SZGR 2.0 genes in this pathway
AZARE NEOPLASTIC TRANSFORMATION BY STAT3 UP	121	70	All SZGR 2.0 genes in this pathway
AZARE STAT3 TARGETS	24	12	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP	682	433	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP	570	339	All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 4	110	66	All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF	367	231	All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES	462	273	All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN	784	464	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4	227	149	All SZGR 2.0 genes in this pathway
ANASTASSIOU CANCER MESENCHYMAL TRANSITION SIGNATURE	64	40	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY	1839	928	All SZGR 2.0 genes in this pathway
NABA ECM GLYCOPROTEINS	196	99	All SZGR 2.0 genes in this pathway
NABA CORE MATRISOME	275	148	All SZGR 2.0 genes in this pathway
NABA MATRISOME	1028	559	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	683	690	1A,m8	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-200bc/429	531	537	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-217	573	579	m8	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: FN1