SZGR2

Summary ?

GeneID	23390
Symbol	ZDHHC17
Synonyms	HIP14\|HIP3\|HSPC294\|HYPH
Description	zinc finger DHHC-type containing 17
Reference	MIM:607799\|HGNC:HGNC:18412\|Ensembl:ENSG00000186908\|HPRD:09697\|Vega:OTTHUMG00000169917
Gene type	protein-coding
Map location	12q21.2
Pascal p-value	0.196
Sherlock p-value	0.596
Fetal beta	0.386
DMG	1 (# studies)
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0159

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg07639963	12	77157760	ZDHHC17	5.93E-5	-0.267	0.023	DMG:Wockner_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs10994209	chr10	61877705	ZDHHC17	23390		0.1		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
C4orf41	0.95	0.95
GAPVD1	0.93	0.94
TRIP12	0.93	0.94
USP7	0.93	0.93
SEC63	0.93	0.94
BAG5	0.93	0.94
ZC3H14	0.93	0.93
UTP14C	0.93	0.94
RAD23B	0.93	0.92
FBXO11	0.93	0.94

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.21	-0.78	-0.81
AF347015.31	-0.78	-0.81
MT-CO2	-0.78	-0.81
IFI27	-0.76	-0.78
HIGD1B	-0.76	-0.79
FXYD1	-0.76	-0.78
ENHO	-0.74	-0.81
C1orf54	-0.73	-0.80
AF347015.8	-0.72	-0.77
MT-CYB	-0.72	-0.75

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004871	signal transducer activity	IMP		12761501
GO:0004871	signal transducer activity	ISS		-
GO:0005515	protein binding	IPI		15603740
GO:0016740	transferase activity	IEA		-
GO:0008270	zinc ion binding	IEA		-
GO:0019706	protein-cysteine S-palmitoleyltransferase activity	IDA		15603740
GO:0046872	metal ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0042953	lipoprotein transport	IDA		15603740
GO:0018345	protein palmitoylation	IEA		-
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	IMP		12761501
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	ISS		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000139	Golgi membrane	IEA		-
GO:0005794	Golgi apparatus	IEA		-
GO:0016020	membrane	IEA		-
GO:0016021	integral to membrane	IEA		-
GO:0031410	cytoplasmic vesicle	IEA		-
GO:0030659	cytoplasmic vesicle membrane	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D UP	175	108	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP	185	126	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL	326	213	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN	848	527	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP	424	268	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM	302	191	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS	425	261	All SZGR 2.0 genes in this pathway
TAVAZOIE METASTASIS	108	68	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN	505	328	All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS DN	27	24	All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1	467	251	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-128	489	495	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	489	495	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-142-5p	1786	1792	m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-144	487	493	m8	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-146	273	279	1A	hsa-miR-146a	UGAGAACUGAAUUCCAUGGGUU
miR-146	273	279	1A	hsa-miR-146b^brain	UGAGAACUGAAUUCCAUAGGCU
miR-148/152	1150	1157	1A,m8	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-181	1851	1857	1A	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-200bc/429	2577	2583	1A	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-204/211	1473	1479	m8	hsa-miR-204^brain	UUCCCUUUGUCAUCCUAUGCCU
				hsa-miR-211	UUCCCUUUGUCAUCCUUCGCCU
				hsa-miR-204^brain	UUCCCUUUGUCAUCCUAUGCCU
				hsa-miR-211	UUCCCUUUGUCAUCCUUCGCCU
miR-21	2527	2533	1A	hsa-miR-21^brain	UAGCUUAUCAGACUGAUGUUGA
miR-21	2527	2533	1A	hsa-miR-590	GAGCUUAUUCAUAAAAGUGCAG
miR-27	489	495	m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	489	495	m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-30-5p	1223	1230	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-33	872	878	1A	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	872	878	1A	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-34/449	181	188	1A,m8	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-369-3p	2578	2584	m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-383	1154	1160	1A	hsa-miR-383^brain	AGAUCAGAAGGUGAUUGUGGCU
miR-493-5p	475	481	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-496	1853	1859	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-93.hd/291-3p/294/295/302/372/373/520	677	683	m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU
miR-96	2571	2577	m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: ZDHHC17