Gene Page: FBXO46
Summary ?
| GeneID | 23403 |
| Symbol | FBXO46 |
| Synonyms | 20D7-FC4|FBXO34L|Fbx46 |
| Description | F-box protein 46 |
| Reference | MIM:609117|HGNC:HGNC:25069|Ensembl:ENSG00000177051|Vega:OTTHUMG00000182132 |
| Gene type | protein-coding |
| Map location | 19q13.3 |
| Pascal p-value | 0.21 |
| Fetal beta | 1.183 |
| DMG | 2 (# studies) |
| eGene | Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 2 |
| DMG:Montano_2016 | Genome-wide DNA methylation analysis | This dataset includes 172 replicated associations between CpGs with schizophrenia. | 2 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg09277709 | 19 | 46224285 | FBXO46 | 6.52E-5 | 0.007 | 0.105 | DMG:Montano_2016 |
| cg26562171 | 19 | 46220049 | FBXO46 | 3.73E-9 | -0.013 | 2.38E-6 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CCDC13 | 0.59 | 0.58 |
| MYLK3 | 0.58 | 0.46 |
| WDR66 | 0.57 | 0.49 |
| CCDC151 | 0.57 | 0.51 |
| C1orf222 | 0.56 | 0.57 |
| EFHC2 | 0.56 | 0.50 |
| DCDC2 | 0.56 | 0.45 |
| AC079354.2 | 0.54 | 0.51 |
| AC069154.2 | 0.54 | 0.53 |
| C10orf67 | 0.54 | 0.46 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| DACT1 | -0.32 | -0.18 |
| SLA | -0.32 | -0.17 |
| KLHL1 | -0.30 | -0.16 |
| MYCN | -0.30 | -0.18 |
| KIAA1949 | -0.30 | -0.28 |
| HEBP2 | -0.30 | -0.47 |
| VASH2 | -0.29 | -0.23 |
| TMEM108 | -0.29 | -0.18 |
| SCUBE1 | -0.29 | -0.26 |
| SRGAP1 | -0.29 | -0.23 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| LAIHO COLORECTAL CANCER SERRATED DN | 86 | 47 | All SZGR 2.0 genes in this pathway |
| WANG LMO4 TARGETS UP | 372 | 227 | All SZGR 2.0 genes in this pathway |
| GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN | 335 | 193 | All SZGR 2.0 genes in this pathway |
| GENTILE UV RESPONSE CLUSTER D7 | 40 | 21 | All SZGR 2.0 genes in this pathway |
| GENTILE UV HIGH DOSE DN | 312 | 203 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | All SZGR 2.0 genes in this pathway |
| YAGI AML WITH 11Q23 REARRANGED | 351 | 238 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 4HR DN | 254 | 158 | All SZGR 2.0 genes in this pathway |
| MARTENS BOUND BY PML RARA FUSION | 456 | 287 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS UP | 504 | 321 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |