Gene Page: SIRT5

Summary
GeneID  23408
Symbol  SIRT5
Synonyms  FLJ36950|SIR2L5
Description  sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)
See related  HGNC:14933|MIM:604483|Ensembl:ENSG00000124523|HPRD:06838|
Locus tag  -
Gene type  protein-coding
Map location  6p23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.0159 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003950NAD+ ADP-ribosyltransferase activityTAS10381378 
GO:0003677DNA bindingIEA-
GO:0016787hydrolase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0017136NAD-dependent histone deacetylase activityIEA-
GO:0051287NAD bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006471protein amino acid ADP-ribosylationTAS10381378 
GO:0006476protein amino acid deacetylationIEA-
GO:0006342chromatin silencingTAS10381378 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005677chromatin silencing complexIEA-
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_HDAC_CLASSI_PATHWAY 6650All SZGR genes in this pathway
CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_DN 391222All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_DN 209122All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_6P24_P22_AMPLICON 2117All SZGR genes in this pathway
STEIN_ESRRA_TARGETS_UP 388234All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_UV 6243All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_OPTIMAL_DEBULKING 246152All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN 264159All SZGR genes in this pathway
STEIN_ESRRA_TARGETS 535325All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_NEURAL 12985All SZGR genes in this pathway
KRIEG_KDM3A_TARGETS_NOT_HYPOXIA 208107All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_DN 428246All SZGR genes in this pathway


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