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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: SIRT1

Summary

GeneID

23411

Symbol

SIRT1

Synonyms

SIR2L1

Description

sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)

Locus tag

RP11-57G10.3

Gene type

protein-coding

Map location

10q21.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

AC008073.1

0.90

0.89

ERH

0.90

0.91

RPL17P20

0.87

0.88

SARNP

0.87

PSMA2

0.86

0.87

C18orf21

0.86

RPL6P10

0.85

0.87

RPL26L1

0.85

0.87

PSMB7

0.85

0.86

EIF3M

0.85

0.88

Top 10 negatively co-expressed genes

AF347015.15

-0.61

-0.71

AF347015.8

-0.60

-0.69

AF347015.27

-0.60

-0.68

MT-CYB

-0.60

-0.69

TINAGL1

-0.60

-0.69

AF347015.26

-0.59

-0.73

SLC6A12

-0.59

-0.68

AF347015.2

-0.59

-0.70

EPAS1

-0.59

-0.70

AF347015.33

-0.58

-0.67

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003950

NAD+ ADP-ribosyltransferase activity

TAS

10381378

GO:0003677

DNA binding

IEA

GO:0008270

zinc ion binding

IEA

GO:0008022

protein C-terminus binding

IPI

18203716

GO:0017136

NAD-dependent histone deacetylase activity

IDA

16959573

GO:0016564

transcription repressor activity

IEA

GO:0051287

NAD binding

IEA

GO:0019213

deacetylase activity

IDA

18203716

GO:0046872

metal ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007519

skeletal muscle development

IEA

neuron (GO term level: 8)

GO:0001542

ovulation from ovarian follicle

IEA

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0006471

protein amino acid ADP-ribosylation

TAS

10381378

GO:0006342

chromatin silencing

TAS

10381378

GO:0007283

spermatogenesis

IEA

GO:0006974

response to DNA damage stimulus

IDA

18203716

GO:0006915

apoptosis

IEA

GO:0007275

multicellular organismal development

IEA

GO:0016481

negative regulation of transcription

IEA

GO:0030154

cell differentiation

IEA

GO:0033158

regulation of protein import into nucleus, translocation

IMP

18203716

GO:0051097

negative regulation of helicase activity

IDA

18203716

GO:0016575

histone deacetylation

IEA

GO:0044419

interspecies interaction between organisms

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

IEA

GO:0005677

chromatin silencing complex

IEA

GO:0005737

cytoplasm

IDA

18029348

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
FHL2	AAG11 \| DRAL \| SLIM3	four and a half LIM domains 2	FHL2 interacts with SIRT1.	BIND	15692560
FOXO1	FKH1 \| FKHR \| FOXO1A	forkhead box O1	FOXO1A interacts with SIRT1.	BIND	15692560
FOXO3	AF6q21 \| DKFZp781A0677 \| FKHRL1 \| FKHRL1P2 \| FOXO2 \| FOXO3A \| MGC12739 \| MGC31925	forkhead box O3	FOXO3 interacts with SIRT1.	BIND	14976264
HES1	FLJ20408 \| HES-1 \| HHL \| HRY \| bHLHb39	hairy and enhancer of split 1, (Drosophila)	-	HPRD,BioGRID	12535671
HEY2	CHF1 \| GRIDLOCK \| GRL \| HERP1 \| HESR2 \| HRT2 \| MGC10720 \| bHLHb32	hairy/enhancer-of-split related with YRPW motif 2	-	HPRD,BioGRID	12535671
HIST1H1B	H1 \| H1.5 \| H1F5 \| MGC126630 \| MGC126632	histone cluster 1, H1b	SirT1 interacts with and deacetylates H1b.	BIND	15469825
HIST3H3	H3.4 \| H3/g \| H3FT \| H3t \| MGC126886 \| MGC126888	histone cluster 3, H3	SirT1 interacts with and deacetylates H3.	BIND	15469825
HIST4H4	H4/p \| MGC24116	histone cluster 4, H4	SirT1 interacts with and deacetylates H4.	BIND	15469825
NCOR1	KIAA1047 \| MGC104216 \| N-CoR \| TRAC1 \| hCIT529I10 \| hN-CoR	nuclear receptor co-repressor 1	Sirt1 interacts with NcoR.	BIND	15175761
NCOR2	CTG26 \| SMRT \| SMRTE \| SMRTE-tau \| TNRC14 \| TRAC-1 \| TRAC1	nuclear receptor co-repressor 2	Sirt1 interacts with SMRT.	BIND	15175761

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
BIOCARTA_PML_PATHWAY	17	12	All SZGR genes in this pathway
PID_P73PATHWAY	79	59	All SZGR genes in this pathway
PID_HDAC_CLASSIII_PATHWAY	25	20	All SZGR genes in this pathway
PID_E2F_PATHWAY	74	48	All SZGR genes in this pathway
PID_HIF2PATHWAY	34	29	All SZGR genes in this pathway
PID_HDAC_CLASSI_PATHWAY	66	50	All SZGR genes in this pathway
PID_FOXO_PATHWAY	49	43	All SZGR genes in this pathway
PID_AR_TF_PATHWAY	53	38	All SZGR genes in this pathway
PID_RB_1PATHWAY	65	46	All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN	463	290	All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP	1382	904	All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_LIGHTYELLOW_UP	11	8	All SZGR genes in this pathway
KIM_WT1_TARGETS_DN	459	276	All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN	508	354	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP	1142	669	All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN	800	473	All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP	811	508	All SZGR genes in this pathway
BENPORATH_ES_1	379	235	All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX	230	156	All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215	893	528	All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_UP	205	126	All SZGR genes in this pathway
MCCLUNG_COCAIN_REWARD_4WK	75	47	All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN	271	175	All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED	1229	713	All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K9ME3_UP	141	75	All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_POOR_SURVIVAL_UP	31	22	All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING	510	309	All SZGR genes in this pathway
MATZUK_OVULATION	14	10	All SZGR genes in this pathway
MATZUK_SPERMATOZOA	114	77	All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN	546	362	All SZGR genes in this pathway
MUELLER_PLURINET	299	189	All SZGR genes in this pathway
DANG_BOUND_BY_MYC	1103	714	All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN	1972	1213	All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY	1725	838	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	1211	1218	1A,m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	1211	1217	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	1211	1217	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-128	849	855	m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	849	855	m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-132/212	1614	1620	m8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	1614	1620	m8	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-135	358	364	m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	358	364	m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-138	32	39	1A,m8	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-141/200a	1728	1734	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	1728	1734	m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-153	907	913	1A	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-181	63	69	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-186	1400	1406	1A	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-199	507	513	m8	hsa-miR-199a	CCCAGUGUUCAGACUACCUGUUC
miR-199	507	513	m8	hsa-miR-199b	CCCAGUGUUUAGACUAUCUGUUC
miR-204/211	384	391	1A,m8	hsa-miR-204^brain	UUCCCUUUGUCAUCCUAUGCCU
miR-204/211	384	391	1A,m8	hsa-miR-211	UUCCCUUUGUCAUCCUUCGCCU
miR-217	1519	1526	1A,m8	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU
miR-22	530	537	1A,m8	hsa-miR-22^brain	AAGCUGCCAGUUGAAGAACUGU
miR-23	899	906	1A,m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	899	906	1A,m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-30-5p	67	73	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-34/449	1434	1440	1A	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-369-3p	1113	1119	m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-448	906	913	1A,m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-485-3p	280	286	m8	hsa-miR-485-3p	GUCAUACACGGCUCUCCUCUCU
miR-494	765	772	1A,m8	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU
miR-496	380	386	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-543	367	374	1A,m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-543	367	374	1A,m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-9	404	411	1A,m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.