SZGR2

Summary ?

GeneID	23411
Symbol	SIRT1
Synonyms	SIR2\|SIR2L1\|SIR2alpha
Description	sirtuin 1
Reference	MIM:604479\|HGNC:HGNC:14929\|Ensembl:ENSG00000096717\|HPRD:08381\|Vega:OTTHUMG00000018340
Gene type	protein-coding
Map location	10q21.3
Pascal p-value	0.112
Sherlock p-value	0.004
Fetal beta	1.189
Support	Chromatin Remodeling Genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AC008073.1	0.90	0.89
ERH	0.90	0.91
RPL17P20	0.87	0.88
SARNP	0.87	0.87
PSMA2	0.86	0.87
C18orf21	0.86	0.86
RPL6P10	0.85	0.87
RPL26L1	0.85	0.87
PSMB7	0.85	0.86
EIF3M	0.85	0.88

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.15	-0.61	-0.71
AF347015.8	-0.60	-0.69
AF347015.27	-0.60	-0.68
MT-CYB	-0.60	-0.69
TINAGL1	-0.60	-0.69
AF347015.26	-0.59	-0.73
SLC6A12	-0.59	-0.68
AF347015.2	-0.59	-0.70
EPAS1	-0.59	-0.70
AF347015.33	-0.58	-0.67

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003950	NAD+ ADP-ribosyltransferase activity	TAS		10381378
GO:0003677	DNA binding	IEA		-
GO:0008270	zinc ion binding	IEA		-
GO:0008022	protein C-terminus binding	IPI		18203716
GO:0017136	NAD-dependent histone deacetylase activity	IDA		16959573
GO:0016564	transcription repressor activity	IEA		-
GO:0051287	NAD binding	IEA		-
GO:0019213	deacetylase activity	IDA		18203716
GO:0046872	metal ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007519	skeletal muscle development	IEA	neuron (GO term level: 8)	-
GO:0001542	ovulation from ovarian follicle	IEA		-
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0006471	protein amino acid ADP-ribosylation	TAS		10381378
GO:0006342	chromatin silencing	TAS		10381378
GO:0007283	spermatogenesis	IEA		-
GO:0006974	response to DNA damage stimulus	IDA		18203716
GO:0006915	apoptosis	IEA		-
GO:0007275	multicellular organismal development	IEA		-
GO:0016481	negative regulation of transcription	IEA		-
GO:0030154	cell differentiation	IEA		-
GO:0033158	regulation of protein import into nucleus, translocation	IMP		18203716
GO:0051097	negative regulation of helicase activity	IDA		18203716
GO:0016575	histone deacetylation	IEA		-
GO:0044419	interspecies interaction between organisms	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	IEA		-
GO:0005677	chromatin silencing complex	IEA		-
GO:0005737	cytoplasm	IDA		18029348

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
BIOCARTA PML PATHWAY	17	12	All SZGR 2.0 genes in this pathway
PID P73PATHWAY	79	59	All SZGR 2.0 genes in this pathway
PID HDAC CLASSIII PATHWAY	25	20	All SZGR 2.0 genes in this pathway
PID E2F PATHWAY	74	48	All SZGR 2.0 genes in this pathway
PID HIF2PATHWAY	34	29	All SZGR 2.0 genes in this pathway
PID HDAC CLASSI PATHWAY	66	50	All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY	49	43	All SZGR 2.0 genes in this pathway
PID AR TF PATHWAY	53	38	All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY	65	46	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN	463	290	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS LIGHTYELLOW UP	11	8	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN	459	276	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN	508	354	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP	1142	669	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN	800	473	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
BENPORATH ES 1	379	235	All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX	230	156	All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215	893	528	All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP	205	126	All SZGR 2.0 genes in this pathway
MCCLUNG COCAIN REWARD 4WK	75	47	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN	271	175	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K9ME3 UP	141	75	All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER POOR SURVIVAL UP	31	22	All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING	510	309	All SZGR 2.0 genes in this pathway
MATZUK OVULATION	14	10	All SZGR 2.0 genes in this pathway
MATZUK SPERMATOZOA	114	77	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN	546	362	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY	1725	838	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	1211	1218	1A,m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	1211	1217	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	1211	1217	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-128	849	855	m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	849	855	m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-132/212	1614	1620	m8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	1614	1620	m8	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-135	358	364	m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	358	364	m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-138	32	39	1A,m8	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-141/200a	1728	1734	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	1728	1734	m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-153	907	913	1A	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-181	63	69	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-186	1400	1406	1A	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-199	507	513	m8	hsa-miR-199a	CCCAGUGUUCAGACUACCUGUUC
miR-199	507	513	m8	hsa-miR-199b	CCCAGUGUUUAGACUAUCUGUUC
miR-204/211	384	391	1A,m8	hsa-miR-204^brain	UUCCCUUUGUCAUCCUAUGCCU
miR-204/211	384	391	1A,m8	hsa-miR-211	UUCCCUUUGUCAUCCUUCGCCU
miR-217	1519	1526	1A,m8	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU
miR-22	530	537	1A,m8	hsa-miR-22^brain	AAGCUGCCAGUUGAAGAACUGU
miR-23	899	906	1A,m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	899	906	1A,m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-30-5p	67	73	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-34/449	1434	1440	1A	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-369-3p	1113	1119	m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-448	906	913	1A,m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-485-3p	280	286	m8	hsa-miR-485-3p	GUCAUACACGGCUCUCCUCUCU
miR-494	765	772	1A,m8	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU
miR-496	380	386	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-543	367	374	1A,m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-543	367	374	1A,m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-9	404	411	1A,m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: SIRT1