Summary ?
GeneID23426
SymbolGRIP1
SynonymsGRIP
Descriptionglutamate receptor interacting protein 1
ReferenceMIM:604597|HGNC:HGNC:18708|Ensembl:ENSG00000155974|Vega:OTTHUMG00000169019
Gene typeprotein-coding
Map location12q14.3
Pascal p-value0.336
Fetal beta1.787
SupportG2Cdb.human_mGluR5
Ascano FMRP targets
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ATAD10.930.93
AZIN10.930.94
CNOT70.920.93
AASDHPPT0.920.92
RAB2A0.920.91
PPP1CB0.920.93
CMPK10.920.91
ARCN10.910.91
USP330.910.92
CLASP20.910.91
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.70-0.70
FXYD1-0.69-0.70
AF347015.8-0.67-0.68
AF347015.33-0.67-0.67
AF347015.21-0.66-0.63
AF347015.31-0.66-0.67
AF347015.2-0.66-0.67
HIGD1B-0.66-0.66
EIF4EBP3-0.66-0.69
MT-CYB-0.65-0.66

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0003713transcription coactivator activityNAS15572661 
GO:0005515protein bindingIEA-
GO:0005515protein bindingNAS10197531 
GO:0030159receptor signaling complex scaffold activityNAS10197531 
GO:0050681androgen receptor bindingNAS15572661 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007242intracellular signaling cascadeNAS10197531 
GO:0030521androgen receptor signaling pathwayNAS15572661 
GO:0045893positive regulation of transcription, DNA-dependentNAS15572661 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005783endoplasmic reticulumIEA-
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-
GO:0031410cytoplasmic vesicleIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorTwo-hybridBioGRID10607837 
GRIA1GLUH1 | GLUR1 | GLURA | HBGR1 | MGC133252glutamate receptor, ionotropic, AMPA 1Reconstituted ComplexBioGRID11891216 
GRIA2GLUR2 | GLURB | GluR-K2 | HBGR2glutamate receptor, ionotropic, AMPA 2Reconstituted Complex
Two-hybrid
BioGRID11891216 
GRIA3GLUR-C | GLUR-K3 | GLUR3 | GLURC | MRX94glutamate receptor, ionotrophic, AMPA 3Reconstituted Complex
Two-hybrid
BioGRID11891216 
GRIA4GLUR4 | GLUR4C | GLURDglutamate receptor, ionotrophic, AMPA 4Reconstituted Complex
Two-hybrid
BioGRID11891216 
GRIK1EAA3 | EEA3 | GLR5 | GLUR5glutamate receptor, ionotropic, kainate 1Reconstituted ComplexBioGRID12597860 
GRIK2EAA4 | GLR6 | GLUK6 | GLUR6 | MGC74427 | MRT6glutamate receptor, ionotropic, kainate 2Reconstituted ComplexBioGRID11891216 |12597860 
GRIK3EAA5 | GLR7 | GLUR7 | GluR7aglutamate receptor, ionotropic, kainate 3Reconstituted Complex
Two-hybrid
BioGRID11891216 
GRM3GLUR3 | GPRC1C | MGLUR3 | mGlu3glutamate receptor, metabotropic 3Reconstituted Complex
Two-hybrid
BioGRID11891216 
GRM7FLJ40498 | GLUR7 | GPRC1G | MGLUR7 | mGlu7glutamate receptor, metabotropic 7GRIP interacts with mGluR7b. This interaction was modeled on a demonstrated interaction between GRIP from an unspecified species and human mGluR7b.BIND11891216 
NR2F1COUP-TFI | EAR-3 | EAR3 | ERBAL3 | NR2F2 | SVP44 | TCFCOUP1 | TFCOUP1nuclear receptor subfamily 2, group F, member 1Two-hybridBioGRID10652338 
PRLHRGPR10 | GR3 | MGC126539 | MGC126541 | PrRPRprolactin releasing hormone receptorAffinity Capture-WesternBioGRID11641419 
TESDKFZp586B2022 | MGC1146 | TESS | TESS-2testis derived transcript (3 LIM domains)TES interacts with GRIP1. This interaction was modelled on a demonstrated interaction between human TES and mouse GRIP1.BIND12571287 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA CARM ER PATHWAY 3527All SZGR 2.0 genes in this pathway
BIOCARTA HER2 PATHWAY 2217All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER DN 185115All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW DN 165107All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH DN 180110All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA DN 181107All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER UP 227137All SZGR 2.0 genes in this pathway
TOMLINS METASTASIS DN 2016All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP 428266All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210124All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264159All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
WANG MLL TARGETS 289188All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM A 182108All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway