Summary ?
GeneID2346
SymbolFOLH1
SynonymsFGCP|FOLH|GCP2|GCPII|NAALAD1|NAALAdase|PSM|PSMA|mGCP
Descriptionfolate hydrolase (prostate-specific membrane antigen) 1
ReferenceMIM:600934|HGNC:HGNC:3788|Ensembl:ENSG00000086205|HPRD:02961|Vega:OTTHUMG00000166625
Gene typeprotein-coding
Map location11p11.2
Pascal p-value0.147
Fetal beta-1.642
eGeneCaudate basal ganglia
Putamen basal ganglia
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16869851chr420690056FOLH123460.19trans
rs2017273621148420327FOLH1ENSG00000086205.122.94687E-60.02809895gtex_brain_putamen_basal
rs30456261149027726FOLH1ENSG00000086205.126.63176E-60.02202496gtex_brain_putamen_basal
rs2001433821149034348FOLH1ENSG00000086205.123.06172E-60.02195874gtex_brain_putamen_basal
rs49298841149066537FOLH1ENSG00000086205.127.10429E-60.02163685gtex_brain_putamen_basal
rs28515661149068332FOLH1ENSG00000086205.127.12715E-60.02161890gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004180carboxypeptidase activityIEA-
GO:0016805dipeptidase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0008237metallopeptidase activityIEA-
GO:0008233peptidase activityNAS9375657 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisNAS9375657 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005624membrane fractionTAS8417812 
GO:0005634nucleusIDA18029348 
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS8417812 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
ROVERSI GLIOMA COPY NUMBER UP 10075All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM UP 8157All SZGR 2.0 genes in this pathway
FALVELLA SMOKERS WITH LUNG CANCER 8052All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160110All SZGR 2.0 genes in this pathway
CHESLER BRAIN QTL CIS 7551All SZGR 2.0 genes in this pathway
CHESLER BRAIN HIGHEST GENETIC VARIANCE 3721All SZGR 2.0 genes in this pathway
FRASOR RESPONSE TO ESTRADIOL DN 8252All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546351All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS DN 234137All SZGR 2.0 genes in this pathway
SUZUKI RESPONSE TO TSA AND DECITABINE 1A 2316All SZGR 2.0 genes in this pathway
YEGNASUBRAMANIAN PROSTATE CANCER 12860All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA RADIATION 8159All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP 226164All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315197All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN 564326All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648398All SZGR 2.0 genes in this pathway
NAKAMURA METASTASIS MODEL UP 4526All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE DN 204114All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS POLYSOMY7 UP 7950All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP 221135All SZGR 2.0 genes in this pathway