Gene Page: TNFRSF13B
Summary ?
| GeneID | 23495 |
| Symbol | TNFRSF13B |
| Synonyms | CD267|CVID|CVID2|IGAD2|RYZN|TACI|TNFRSF14B |
| Description | tumor necrosis factor receptor superfamily member 13B |
| Reference | MIM:604907|HGNC:HGNC:18153|Ensembl:ENSG00000240505|HPRD:05365|Vega:OTTHUMG00000059262 |
| Gene type | protein-coding |
| Map location | 17p11.2 |
| Pascal p-value | 0.744 |
| Fetal beta | 0.124 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg13195185 | 17 | 16875596 | TNFRSF13B | 1.771E-4 | 0.274 | 0.034 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs13271783 | chr8 | 3384743 | TNFRSF13B | 23495 | 0.1 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| WSB1 | 0.73 | 0.56 |
| LENG8 | 0.72 | 0.57 |
| AC174470.2 | 0.72 | 0.47 |
| NKTR | 0.72 | 0.52 |
| SEC31B | 0.71 | 0.54 |
| HPX | 0.71 | 0.49 |
| TARBP1 | 0.71 | 0.52 |
| ZMYND17 | 0.71 | 0.46 |
| FGFR4 | 0.71 | 0.49 |
| GSDMB | 0.70 | 0.45 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| TM4SF18 | -0.34 | -0.39 |
| ITM2A | -0.32 | -0.42 |
| SERGEF | -0.31 | -0.33 |
| IGFBP7 | -0.31 | -0.38 |
| CXCL14 | -0.31 | -0.36 |
| GNG11 | -0.30 | -0.47 |
| MYL12A | -0.30 | -0.32 |
| COX5B | -0.30 | -0.35 |
| CHPT1 | -0.30 | -0.36 |
| GIMAP5 | -0.30 | -0.35 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION | 267 | 161 | All SZGR 2.0 genes in this pathway |
| KEGG INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION | 48 | 36 | All SZGR 2.0 genes in this pathway |
| KEGG PRIMARY IMMUNODEFICIENCY | 35 | 28 | All SZGR 2.0 genes in this pathway |
| BIOCARTA TALL1 PATHWAY | 15 | 15 | All SZGR 2.0 genes in this pathway |
| PID SYNDECAN 4 PATHWAY | 32 | 25 | All SZGR 2.0 genes in this pathway |
| PID SYNDECAN 2 PATHWAY | 33 | 27 | All SZGR 2.0 genes in this pathway |
| KLEIN TARGETS OF BCR ABL1 FUSION | 45 | 34 | All SZGR 2.0 genes in this pathway |
| MOREAUX MULTIPLE MYELOMA BY TACI UP | 412 | 249 | All SZGR 2.0 genes in this pathway |
| GAVIN FOXP3 TARGETS CLUSTER P7 | 90 | 52 | All SZGR 2.0 genes in this pathway |
| GRADE COLON VS RECTAL CANCER DN | 56 | 36 | All SZGR 2.0 genes in this pathway |
| GUTIERREZ WALDENSTROEMS MACROGLOBULINEMIA 1 DN | 9 | 7 | All SZGR 2.0 genes in this pathway |
| TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN | 321 | 200 | All SZGR 2.0 genes in this pathway |