Summary ?
GeneID2356
SymbolFPGS
Synonyms-
Descriptionfolylpolyglutamate synthase
ReferenceMIM:136510|HGNC:HGNC:3824|Ensembl:ENSG00000136877|HPRD:00642|Vega:OTTHUMG00000020716
Gene typeprotein-coding
Map location9q34.1
Pascal p-value0.142
Sherlock p-value0.755
Fetal beta-0.275
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg119736889130564956FPGS5.93E-10-0.0119.07E-7DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17542473chr4111182451FPGS23560.17trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004326tetrahydrofolylpolyglutamate synthase activityIEAglutamate (GO term level: 6)-
GO:0004326tetrahydrofolylpolyglutamate synthase activityISSglutamate (GO term level: 6)10964921 
GO:0004326tetrahydrofolylpolyglutamate synthase activityTASglutamate (GO term level: 6)7721888 
GO:0000166nucleotide bindingIEA-
GO:0005524ATP bindingIEA-
GO:0016874ligase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0009116nucleoside metabolic processISS10964921 
GO:0006139nucleobase, nucleoside, nucleotide and nucleic acid metabolic processTAS7721888 
GO:0009396folic acid and derivative biosynthetic processIEA-
GO:0009058biosynthetic processIEA-
GO:0006730one-carbon compound metabolic processIEA-
GO:0006544glycine metabolic processISS10964921 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolTAS7721888 
GO:0005737cytoplasmTAS1409616 
GO:0005739mitochondrionTAS7721888 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG FOLATE BIOSYNTHESIS 1110All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF VITAMINS AND COFACTORS 5136All SZGR 2.0 genes in this pathway
SCHLOSSER MYC AND SERUM RESPONSE SYNERGY 3222All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230156All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC 182116All SZGR 2.0 genes in this pathway
ZHAN V2 LATE DIFFERENTIATION GENES 4534All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532309All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429260All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA 447277All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 UP 344215All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS DN 14888All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157105All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway