Gene Page: AMACR
Summary ?
| GeneID | 23600 |
| Symbol | AMACR |
| Synonyms | AMACRD|CBAS4|RACE|RM |
| Description | alpha-methylacyl-CoA racemase |
| Reference | MIM:604489|HGNC:HGNC:451|Ensembl:ENSG00000242110|HPRD:05134|Vega:OTTHUMG00000090734 |
| Gene type | protein-coding |
| Map location | 5p13 |
| Pascal p-value | 0.739 |
| Sherlock p-value | 0.915 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs168803 | chr5 | 33995704 | AMACR | 23600 | 1.235E-5 | cis | ||
| rs840399 | chr5 | 34015680 | AMACR | 23600 | 7.743E-5 | cis | ||
| rs840391 | chr5 | 34018503 | AMACR | 23600 | 0.03 | cis | ||
| rs971074 | chr4 | 100341860 | AMACR | 23600 | 0.14 | trans | ||
| rs168803 | chr5 | 33995704 | AMACR | 23600 | 0 | trans | ||
| rs840399 | chr5 | 34015680 | AMACR | 23600 | 0.01 | trans | ||
| rs253189 | 5 | 33993865 | AMACR | ENSG00000242110.3 | 6.586E-8 | 0 | 14355 | gtex_brain_ba24 |
| rs10472909 | 5 | 33994116 | AMACR | ENSG00000242110.3 | 3.001E-9 | 0 | 14104 | gtex_brain_ba24 |
| rs11742345 | 5 | 33994316 | AMACR | ENSG00000242110.3 | 1.317E-9 | 0 | 13904 | gtex_brain_ba24 |
| rs168803 | 5 | 33995705 | AMACR | ENSG00000242110.3 | 7.795E-8 | 0 | 12515 | gtex_brain_ba24 |
| rs9918189 | 5 | 33996454 | AMACR | ENSG00000242110.3 | 8.832E-10 | 0 | 11766 | gtex_brain_ba24 |
| rs10941110 | 5 | 33999079 | AMACR | ENSG00000242110.3 | 1.819E-10 | 0 | 9141 | gtex_brain_ba24 |
| rs10941112 | 5 | 34004707 | AMACR | ENSG00000242110.3 | 1.535E-10 | 0 | 3513 | gtex_brain_ba24 |
| rs386403520 | 5 | 34005414 | AMACR | ENSG00000242110.3 | 7.773E-10 | 0 | 2806 | gtex_brain_ba24 |
| rs3195676 | 5 | 34008100 | AMACR | ENSG00000242110.3 | 7.791E-10 | 0 | 120 | gtex_brain_ba24 |
| rs3217251 | 5 | 34008206 | AMACR | ENSG00000242110.3 | 7.663E-10 | 0 | 14 | gtex_brain_ba24 |
| rs6875926 | 5 | 34012492 | AMACR | ENSG00000242110.3 | 8.021E-10 | 0 | -4272 | gtex_brain_ba24 |
| rs253200 | 5 | 34012564 | AMACR | ENSG00000242110.3 | 8.802E-8 | 0 | -4344 | gtex_brain_ba24 |
| rs194126 | 5 | 34014022 | AMACR | ENSG00000242110.3 | 2.147E-9 | 0 | -5802 | gtex_brain_ba24 |
| rs253202 | 5 | 34015174 | AMACR | ENSG00000242110.3 | 1.671E-7 | 0 | -6954 | gtex_brain_ba24 |
| rs840399 | 5 | 34015681 | AMACR | ENSG00000242110.3 | 3.317E-7 | 0 | -7461 | gtex_brain_ba24 |
| rs840398 | 5 | 34016023 | AMACR | ENSG00000242110.3 | 3.317E-7 | 0 | -7803 | gtex_brain_ba24 |
| rs840397 | 5 | 34016138 | AMACR | ENSG00000242110.3 | 1.504E-7 | 0 | -7918 | gtex_brain_ba24 |
| rs840396 | 5 | 34016484 | AMACR | ENSG00000242110.3 | 1.945E-7 | 0 | -8264 | gtex_brain_ba24 |
| rs840395 | 5 | 34016554 | AMACR | ENSG00000242110.3 | 6.333E-7 | 0 | -8334 | gtex_brain_ba24 |
| rs840391 | 5 | 34018504 | AMACR | ENSG00000242110.3 | 2.589E-6 | 0 | -10284 | gtex_brain_ba24 |
| rs840389 | 5 | 34018684 | AMACR | ENSG00000242110.3 | 2.586E-6 | 0 | -10464 | gtex_brain_ba24 |
| rs840388 | 5 | 34018890 | AMACR | ENSG00000242110.3 | 2.586E-6 | 0 | -10670 | gtex_brain_ba24 |
| rs840387 | 5 | 34019048 | AMACR | ENSG00000242110.3 | 2.586E-6 | 0 | -10828 | gtex_brain_ba24 |
| rs840385 | 5 | 34020358 | AMACR | ENSG00000242110.3 | 2.586E-6 | 0 | -12138 | gtex_brain_ba24 |
| rs840382 | 5 | 34021706 | AMACR | ENSG00000242110.3 | 2.567E-6 | 0 | -13486 | gtex_brain_ba24 |
| rs10941113 | 5 | 34026756 | AMACR | ENSG00000242110.3 | 7.564E-7 | 0 | -18536 | gtex_brain_ba24 |
| rs7721230 | 5 | 33992529 | AMACR | ENSG00000242110.3 | 3.04E-6 | 0 | 15691 | gtex_brain_putamen_basal |
| rs253189 | 5 | 33993865 | AMACR | ENSG00000242110.3 | 1.572E-6 | 0 | 14355 | gtex_brain_putamen_basal |
| rs10472909 | 5 | 33994116 | AMACR | ENSG00000242110.3 | 1.05E-8 | 0 | 14104 | gtex_brain_putamen_basal |
| rs11742345 | 5 | 33994316 | AMACR | ENSG00000242110.3 | 5.599E-9 | 0 | 13904 | gtex_brain_putamen_basal |
| rs168803 | 5 | 33995705 | AMACR | ENSG00000242110.3 | 1.446E-7 | 0 | 12515 | gtex_brain_putamen_basal |
| rs9918189 | 5 | 33996454 | AMACR | ENSG00000242110.3 | 1.333E-10 | 0 | 11766 | gtex_brain_putamen_basal |
| rs10941110 | 5 | 33999079 | AMACR | ENSG00000242110.3 | 6.441E-11 | 0 | 9141 | gtex_brain_putamen_basal |
| rs10941112 | 5 | 34004707 | AMACR | ENSG00000242110.3 | 3.134E-10 | 0 | 3513 | gtex_brain_putamen_basal |
| rs386403520 | 5 | 34005414 | AMACR | ENSG00000242110.3 | 5.633E-10 | 0 | 2806 | gtex_brain_putamen_basal |
| rs3195676 | 5 | 34008100 | AMACR | ENSG00000242110.3 | 5.633E-10 | 0 | 120 | gtex_brain_putamen_basal |
| rs3217251 | 5 | 34008206 | AMACR | ENSG00000242110.3 | 1.486E-9 | 0 | 14 | gtex_brain_putamen_basal |
| rs6875926 | 5 | 34012492 | AMACR | ENSG00000242110.3 | 5.669E-10 | 0 | -4272 | gtex_brain_putamen_basal |
| rs253200 | 5 | 34012564 | AMACR | ENSG00000242110.3 | 1.058E-6 | 0 | -4344 | gtex_brain_putamen_basal |
| rs194126 | 5 | 34014022 | AMACR | ENSG00000242110.3 | 3.254E-7 | 0 | -5802 | gtex_brain_putamen_basal |
| rs10941113 | 5 | 34026756 | AMACR | ENSG00000242110.3 | 2.838E-6 | 0 | -18536 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG PRIMARY BILE ACID BIOSYNTHESIS | 16 | 9 | All SZGR 2.0 genes in this pathway |
| KEGG PEROXISOME | 78 | 47 | All SZGR 2.0 genes in this pathway |
| REACTOME BILE ACID AND BILE SALT METABOLISM | 27 | 11 | All SZGR 2.0 genes in this pathway |
| REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | 15 | 6 | All SZGR 2.0 genes in this pathway |
| REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | 10 | 6 | All SZGR 2.0 genes in this pathway |
| REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS | 19 | 9 | All SZGR 2.0 genes in this pathway |
| REACTOME PEROXISOMAL LIPID METABOLISM | 21 | 11 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | 478 | 302 | All SZGR 2.0 genes in this pathway |
| LIU PROSTATE CANCER UP | 96 | 57 | All SZGR 2.0 genes in this pathway |
| DACOSTA UV RESPONSE VIA ERCC3 TTD UP | 64 | 39 | All SZGR 2.0 genes in this pathway |
| FARMER BREAST CANCER APOCRINE VS BASAL | 330 | 217 | All SZGR 2.0 genes in this pathway |
| FARMER BREAST CANCER BASAL VS LULMINAL | 330 | 215 | All SZGR 2.0 genes in this pathway |
| AMUNDSON GENOTOXIC SIGNATURE | 105 | 68 | All SZGR 2.0 genes in this pathway |
| TOMLINS PROSTATE CANCER UP | 40 | 27 | All SZGR 2.0 genes in this pathway |
| SMITH LIVER CANCER | 45 | 27 | All SZGR 2.0 genes in this pathway |
| HOWLIN CITED1 TARGETS 1 DN | 37 | 22 | All SZGR 2.0 genes in this pathway |
| HOWLIN CITED1 TARGETS 2 DN | 17 | 11 | All SZGR 2.0 genes in this pathway |
| WALLACE PROSTATE CANCER UP | 20 | 14 | All SZGR 2.0 genes in this pathway |
| OUYANG PROSTATE CANCER MARKERS | 19 | 16 | All SZGR 2.0 genes in this pathway |
| MOOTHA HUMAN MITODB 6 2002 | 429 | 260 | All SZGR 2.0 genes in this pathway |
| MOOTHA PGC | 420 | 269 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER SURVIVAL UP | 185 | 112 | All SZGR 2.0 genes in this pathway |
| MOOTHA MITOCHONDRIA | 447 | 277 | All SZGR 2.0 genes in this pathway |
| CHIANG LIVER CANCER SUBCLASS CTNNB1 UP | 176 | 110 | All SZGR 2.0 genes in this pathway |
| CHIANG LIVER CANCER SUBCLASS INTERFERON DN | 52 | 30 | All SZGR 2.0 genes in this pathway |
| MOOTHA FFA OXYDATION | 22 | 13 | All SZGR 2.0 genes in this pathway |
| WIERENGA STAT5A TARGETS UP | 217 | 131 | All SZGR 2.0 genes in this pathway |
| WIERENGA STAT5A TARGETS GROUP1 | 136 | 76 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| DELACROIX RAR BOUND ES | 462 | 273 | All SZGR 2.0 genes in this pathway |