Gene Page: SH3BP1
Summary ?
| GeneID | 23616 |
| Symbol | SH3BP1 |
| Synonyms | ARHGAP43 |
| Description | SH3-domain binding protein 1 |
| Reference | HGNC:HGNC:10824|Ensembl:ENSG00000100092|HPRD:10227|Vega:OTTHUMG00000030996 |
| Gene type | protein-coding |
| Map location | 22q13.1 |
| Pascal p-value | 0.756 |
| Sherlock p-value | 4.225E-4 |
| DEG p-value | DEG:Zhao_2015:p=4.81e-04:q=0.0926 |
| Fetal beta | -0.317 |
| DMG | 1 (# studies) |
| eGene | Cerebellum Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| DEG:Zhao_2015 | RNA Sequencing analysis | Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder. | |
| DMG:vanEijk_2014 | Genome-wide DNA methylation analysis | This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg22031736 | 22 | 38239648 | SH3BP1 | 4.181E-4 | 4.775 | DMG:vanEijk_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs11127467 | chr2 | 12993 | SH3BP1 | 23616 | 0 | trans | ||
| rs921163 | chr2 | 205337399 | SH3BP1 | 23616 | 0.19 | trans | ||
| rs13003798 | chr2 | 205355767 | SH3BP1 | 23616 | 0.15 | trans | ||
| rs10934268 | chr3 | 114060960 | SH3BP1 | 23616 | 0.03 | trans | ||
| rs16827037 | chr3 | 117203284 | SH3BP1 | 23616 | 5.331E-4 | trans | ||
| rs16865151 | chr3 | 189900081 | SH3BP1 | 23616 | 0.19 | trans | ||
| rs12652146 | chr5 | 54573379 | SH3BP1 | 23616 | 0.13 | trans | ||
| rs1009606 | chr6 | 5726368 | SH3BP1 | 23616 | 0.11 | trans | ||
| rs887719 | chr7 | 21184272 | SH3BP1 | 23616 | 0.04 | trans | ||
| rs320082 | chr7 | 29105404 | SH3BP1 | 23616 | 0.01 | trans | ||
| rs317720 | chr7 | 29110633 | SH3BP1 | 23616 | 0.09 | trans | ||
| rs317714 | chr7 | 29115553 | SH3BP1 | 23616 | 0 | trans | ||
| rs317724 | chr7 | 29120565 | SH3BP1 | 23616 | 0.09 | trans | ||
| rs1419793 | chr7 | 34697630 | SH3BP1 | 23616 | 0.03 | trans | ||
| rs17166659 | chr7 | 132342143 | SH3BP1 | 23616 | 0.14 | trans | ||
| rs16891454 | chr8 | 42485539 | SH3BP1 | 23616 | 0.14 | trans | ||
| rs16886605 | chr8 | 115894398 | SH3BP1 | 23616 | 0 | trans | ||
| rs1494750 | chr8 | 116094224 | SH3BP1 | 23616 | 0.06 | trans | ||
| rs1020772 | chr9 | 76532511 | SH3BP1 | 23616 | 0.02 | trans | ||
| rs10834670 | chr11 | 25404015 | SH3BP1 | 23616 | 0 | trans | ||
| rs10834671 | chr11 | 25404269 | SH3BP1 | 23616 | 0 | trans | ||
| rs11066476 | chr12 | 113465366 | SH3BP1 | 23616 | 0.12 | trans | ||
| rs11043285 | chr12 | 122443533 | SH3BP1 | 23616 | 0.19 | trans | ||
| rs7971538 | chr12 | 122473662 | SH3BP1 | 23616 | 0.19 | trans | ||
| rs4497566 | chr13 | 51694324 | SH3BP1 | 23616 | 0.04 | trans | ||
| rs1307687 | 0 | SH3BP1 | 23616 | 0.11 | trans | |||
| rs837356 | chr16 | 9470886 | SH3BP1 | 23616 | 0.1 | trans | ||
| rs7230403 | chr18 | 54982203 | SH3BP1 | 23616 | 0.18 | trans | ||
| rs1230712 | chr18 | 54992531 | SH3BP1 | 23616 | 0.05 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN | 335 | 193 | All SZGR 2.0 genes in this pathway |
| HAMAI APOPTOSIS VIA TRAIL DN | 186 | 107 | All SZGR 2.0 genes in this pathway |
| MA MYELOID DIFFERENTIATION DN | 44 | 30 | All SZGR 2.0 genes in this pathway |
| QI PLASMACYTOMA UP | 259 | 185 | All SZGR 2.0 genes in this pathway |
| BOYLAN MULTIPLE MYELOMA D CLUSTER DN | 40 | 26 | All SZGR 2.0 genes in this pathway |
| BOYLAN MULTIPLE MYELOMA D DN | 78 | 34 | All SZGR 2.0 genes in this pathway |
| VANTVEER BREAST CANCER ESR1 DN | 240 | 153 | All SZGR 2.0 genes in this pathway |
| AGUIRRE PANCREATIC CANCER COPY NUMBER DN | 238 | 145 | All SZGR 2.0 genes in this pathway |
| BOYLAN MULTIPLE MYELOMA PCA3 DN | 69 | 38 | All SZGR 2.0 genes in this pathway |
| ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN | 116 | 74 | All SZGR 2.0 genes in this pathway |
| WANG NFKB TARGETS | 25 | 15 | All SZGR 2.0 genes in this pathway |
| DELACROIX RARG BOUND MEF | 367 | 231 | All SZGR 2.0 genes in this pathway |
| DELACROIX RAR BOUND ES | 462 | 273 | All SZGR 2.0 genes in this pathway |