Summary ?
GeneID23787
SymbolMTCH1
SynonymsCGI-64|PIG60|PSAP|SLC25A49
Descriptionmitochondrial carrier 1
ReferenceMIM:610449|HGNC:HGNC:17586|Ensembl:ENSG00000137409|HPRD:14787|Vega:OTTHUMG00000014614
Gene typeprotein-coding
Map location6p21.2
Pascal p-value0.304
Sherlock p-value0.335
Fetal beta-1.887
DMG1 (# studies)
eGeneHypothalamus
Myers' cis & trans
Meta
SupportG2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_mitochondria

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GSMA_IGenome scan meta-analysisPsr: 0.033 
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.04433 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg12592908636954170MTCH14.132E-4-0.3490.044DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs9366917chr636790665MTCH1237870.14cis

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005488bindingIEA-
GO:0005515protein bindingIPI12377771 
GO:0005515protein bindingISS-
GO:0030165PDZ domain bindingNAS10551805 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0045161neuronal ion channel clusteringNASneuron (GO term level: 11)10551805 
GO:0009966regulation of signal transductionNAS10551805 
GO:0006810transportIEA-
GO:0006919caspase activationIMP12377771 
GO:0006919caspase activationISS-
GO:0043065positive regulation of apoptosisIEP12377771 
GO:0043065positive regulation of apoptosisISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularNAS10551805 
GO:0005739mitochondrionIMP12377771 
GO:0005739mitochondrionISS-
GO:0005743mitochondrial inner membraneIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
OSMAN BLADDER CANCER DN 406230All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557331All SZGR 2.0 genes in this pathway
ALCALA APOPTOSIS 8860All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR DN 5745All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP 157105All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
LEIN LOCALIZED TO PROXIMAL DENDRITES 3726All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE UP 12589All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429260All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA 447277All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA D CLUSTER DN 4026All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA D DN 7834All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-330416422m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA