Gene Page: ALOX15
Summary ?
| GeneID | 246 |
| Symbol | ALOX15 |
| Synonyms | 12-LOX|15-LOX-1|15LOX-1 |
| Description | arachidonate 15-lipoxygenase |
| Reference | MIM:152392|HGNC:HGNC:433|Ensembl:ENSG00000161905|HPRD:01067|Vega:OTTHUMG00000090746 |
| Gene type | protein-coding |
| Map location | 17p13.3 |
| Pascal p-value | 0.176 |
| eGene | Anterior cingulate cortex BA24 Cerebellum Cortex Hypothalamus Meta |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ALOX15 | chr17 | 4542904 | A | G | NM_001140 | p.53V>A | missense | Schizophrenia | DNM:Fromer_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs2255888 | 17 | 4545581 | ALOX15 | ENSG00000161905.8 | 8.829E-9 | 0 | 8 | gtex_brain_ba24 |
| rs11568061 | 17 | 4546445 | ALOX15 | ENSG00000161905.8 | 1.333E-8 | 0 | -856 | gtex_brain_ba24 |
| rs9894225 | 17 | 4546559 | ALOX15 | ENSG00000161905.8 | 7.286E-9 | 0 | -970 | gtex_brain_ba24 |
| rs9906642 | 17 | 4546989 | ALOX15 | ENSG00000161905.8 | 2.638E-8 | 0 | -1400 | gtex_brain_ba24 |
| rs71147071 | 17 | 4547001 | ALOX15 | ENSG00000161905.8 | 2.638E-8 | 0 | -1412 | gtex_brain_ba24 |
| rs7213481 | 17 | 4547906 | ALOX15 | ENSG00000161905.8 | 1.251E-8 | 0 | -2317 | gtex_brain_ba24 |
| rs145394571 | 17 | 4550672 | ALOX15 | ENSG00000161905.8 | 1.242E-8 | 0 | -5083 | gtex_brain_ba24 |
| rs397748648 | 17 | 4551079 | ALOX15 | ENSG00000161905.8 | 1.295E-8 | 0 | -5490 | gtex_brain_ba24 |
| rs58176940 | 17 | 4552955 | ALOX15 | ENSG00000161905.8 | 1.434E-8 | 0 | -7366 | gtex_brain_ba24 |
| rs72835619 | 17 | 4557285 | ALOX15 | ENSG00000161905.8 | 2.043E-8 | 0 | -11696 | gtex_brain_ba24 |
| rs72835620 | 17 | 4558128 | ALOX15 | ENSG00000161905.8 | 2.217E-8 | 0 | -12539 | gtex_brain_ba24 |
| rs9905711 | 17 | 4558662 | ALOX15 | ENSG00000161905.8 | 3.242E-8 | 0 | -13073 | gtex_brain_ba24 |
| rs139021596 | 17 | 4559281 | ALOX15 | ENSG00000161905.8 | 2.286E-8 | 0 | -13692 | gtex_brain_ba24 |
| rs11655203 | 17 | 4559393 | ALOX15 | ENSG00000161905.8 | 9.158E-8 | 0 | -13804 | gtex_brain_ba24 |
| rs4790670 | 17 | 4559833 | ALOX15 | ENSG00000161905.8 | 1.566E-8 | 0 | -14244 | gtex_brain_ba24 |
| rs61320021 | 17 | 4559853 | ALOX15 | ENSG00000161905.8 | 2.695E-8 | 0 | -14264 | gtex_brain_ba24 |
| rs12941694 | 17 | 4560033 | ALOX15 | ENSG00000161905.8 | 1.613E-7 | 0 | -14444 | gtex_brain_ba24 |
| rs56170457 | 17 | 4560141 | ALOX15 | ENSG00000161905.8 | 5.124E-8 | 0 | -14552 | gtex_brain_ba24 |
| rs72835625 | 17 | 4560274 | ALOX15 | ENSG00000161905.8 | 2.822E-8 | 0 | -14685 | gtex_brain_ba24 |
| rs72835626 | 17 | 4560326 | ALOX15 | ENSG00000161905.8 | 5.228E-8 | 0 | -14737 | gtex_brain_ba24 |
| rs55986729 | 17 | 4560499 | ALOX15 | ENSG00000161905.8 | 5.439E-8 | 0 | -14910 | gtex_brain_ba24 |
| rs56020376 | 17 | 4560909 | ALOX15 | ENSG00000161905.8 | 3.125E-8 | 0 | -15320 | gtex_brain_ba24 |
| rs2054467 | 17 | 4561074 | ALOX15 | ENSG00000161905.8 | 2.212E-7 | 0 | -15485 | gtex_brain_ba24 |
| rs56124631 | 17 | 4561378 | ALOX15 | ENSG00000161905.8 | 6.098E-8 | 0 | -15789 | gtex_brain_ba24 |
| rs55981776 | 17 | 4561401 | ALOX15 | ENSG00000161905.8 | 6.098E-8 | 0 | -15812 | gtex_brain_ba24 |
| rs55780247 | 17 | 4561499 | ALOX15 | ENSG00000161905.8 | 3.39E-8 | 0 | -15910 | gtex_brain_ba24 |
| rs56357040 | 17 | 4561566 | ALOX15 | ENSG00000161905.8 | 6.232E-8 | 0 | -15977 | gtex_brain_ba24 |
| rs7215274 | 17 | 4561834 | ALOX15 | ENSG00000161905.8 | 6.43E-8 | 0 | -16245 | gtex_brain_ba24 |
| rs7219606 | 17 | 4561928 | ALOX15 | ENSG00000161905.8 | 6.49E-8 | 0 | -16339 | gtex_brain_ba24 |
| rs7213896 | 17 | 4562082 | ALOX15 | ENSG00000161905.8 | 6.49E-8 | 0 | -16493 | gtex_brain_ba24 |
| rs7223840 | 17 | 4562150 | ALOX15 | ENSG00000161905.8 | 5.918E-8 | 0 | -16561 | gtex_brain_ba24 |
| rs7217849 | 17 | 4562165 | ALOX15 | ENSG00000161905.8 | 6.49E-8 | 0 | -16576 | gtex_brain_ba24 |
| rs7219787 | 17 | 4562257 | ALOX15 | ENSG00000161905.8 | 6.664E-8 | 0 | -16668 | gtex_brain_ba24 |
| rs398119647 | 17 | 4562356 | ALOX15 | ENSG00000161905.8 | 6.584E-8 | 0 | -16767 | gtex_brain_ba24 |
| rs72835630 | 17 | 4562449 | ALOX15 | ENSG00000161905.8 | 6.49E-8 | 0 | -16860 | gtex_brain_ba24 |
| rs56364707 | 17 | 4562579 | ALOX15 | ENSG00000161905.8 | 6.49E-8 | 0 | -16990 | gtex_brain_ba24 |
| rs55959711 | 17 | 4562581 | ALOX15 | ENSG00000161905.8 | 3.567E-8 | 0 | -16992 | gtex_brain_ba24 |
| rs55782417 | 17 | 4562845 | ALOX15 | ENSG00000161905.8 | 3.567E-8 | 0 | -17256 | gtex_brain_ba24 |
| rs55869432 | 17 | 4562901 | ALOX15 | ENSG00000161905.8 | 6.49E-8 | 0 | -17312 | gtex_brain_ba24 |
| rs72835635 | 17 | 4563127 | ALOX15 | ENSG00000161905.8 | 6.49E-8 | 0 | -17538 | gtex_brain_ba24 |
| rs4790671 | 17 | 4563444 | ALOX15 | ENSG00000161905.8 | 4.33E-8 | 0 | -17855 | gtex_brain_ba24 |
| rs9911552 | 17 | 4563489 | ALOX15 | ENSG00000161905.8 | 3.69E-8 | 0 | -17900 | gtex_brain_ba24 |
| rs145594351 | 17 | 4563608 | ALOX15 | ENSG00000161905.8 | 3.229E-8 | 0 | -18019 | gtex_brain_ba24 |
| rs56184690 | 17 | 4563660 | ALOX15 | ENSG00000161905.8 | 3.202E-8 | 0 | -18071 | gtex_brain_ba24 |
| rs369347996 | 17 | 4564654 | ALOX15 | ENSG00000161905.8 | 2.649E-8 | 0 | -19065 | gtex_brain_ba24 |
| rs4538065 | 17 | 4566015 | ALOX15 | ENSG00000161905.8 | 6.064E-8 | 0 | -20426 | gtex_brain_ba24 |
| rs4346260 | 17 | 4567215 | ALOX15 | ENSG00000161905.8 | 5.518E-8 | 0 | -21626 | gtex_brain_ba24 |
| rs8074545 | 17 | 4567337 | ALOX15 | ENSG00000161905.8 | 5.063E-8 | 0 | -21748 | gtex_brain_ba24 |
| rs55974786 | 17 | 4567564 | ALOX15 | ENSG00000161905.8 | 1.649E-8 | 0 | -21975 | gtex_brain_ba24 |
| rs4470203 | 17 | 4567798 | ALOX15 | ENSG00000161905.8 | 8.678E-9 | 0 | -22209 | gtex_brain_ba24 |
| rs9916135 | 17 | 4568115 | ALOX15 | ENSG00000161905.8 | 4.614E-8 | 0 | -22526 | gtex_brain_ba24 |
| rs9915105 | 17 | 4568742 | ALOX15 | ENSG00000161905.8 | 1.889E-8 | 0 | -23153 | gtex_brain_ba24 |
| rs68190844 | 17 | 4568953 | ALOX15 | ENSG00000161905.8 | 4.208E-8 | 0 | -23364 | gtex_brain_ba24 |
| rs5818975 | 17 | 4569846 | ALOX15 | ENSG00000161905.8 | 4.101E-9 | 0 | -24257 | gtex_brain_ba24 |
| rs4416072 | 17 | 4570036 | ALOX15 | ENSG00000161905.8 | 4.014E-9 | 0 | -24447 | gtex_brain_ba24 |
| rs9901930 | 17 | 4570233 | ALOX15 | ENSG00000161905.8 | 5.458E-9 | 0 | -24644 | gtex_brain_ba24 |
| rs9904358 | 17 | 4570263 | ALOX15 | ENSG00000161905.8 | 8.352E-9 | 0 | -24674 | gtex_brain_ba24 |
| rs372648332 | 17 | 4570466 | ALOX15 | ENSG00000161905.8 | 2.336E-8 | 0 | -24877 | gtex_brain_ba24 |
| rs11657052 | 17 | 4570573 | ALOX15 | ENSG00000161905.8 | 5.149E-9 | 0 | -24984 | gtex_brain_ba24 |
| rs56396454 | 17 | 4571037 | ALOX15 | ENSG00000161905.8 | 1.109E-8 | 0 | -25448 | gtex_brain_ba24 |
| rs149745524 | 17 | 4571287 | ALOX15 | ENSG00000161905.8 | 2.879E-7 | 0 | -25698 | gtex_brain_ba24 |
| rs72068121 | 17 | 4571289 | ALOX15 | ENSG00000161905.8 | 2.82E-7 | 0 | -25700 | gtex_brain_ba24 |
| rs145965968 | 17 | 4572105 | ALOX15 | ENSG00000161905.8 | 1.014E-8 | 0 | -26516 | gtex_brain_ba24 |
| rs142108572 | 17 | 4572470 | ALOX15 | ENSG00000161905.8 | 2.536E-9 | 0 | -26881 | gtex_brain_ba24 |
| rs4790213 | 17 | 4572677 | ALOX15 | ENSG00000161905.8 | 3.498E-8 | 0 | -27088 | gtex_brain_ba24 |
| rs4790214 | 17 | 4573179 | ALOX15 | ENSG00000161905.8 | 3.272E-8 | 0 | -27590 | gtex_brain_ba24 |
| rs72835642 | 17 | 4573407 | ALOX15 | ENSG00000161905.8 | 9.332E-9 | 0 | -27818 | gtex_brain_ba24 |
| rs4790672 | 17 | 4573414 | ALOX15 | ENSG00000161905.8 | 3.231E-8 | 0 | -27825 | gtex_brain_ba24 |
| rs7222133 | 17 | 4573611 | ALOX15 | ENSG00000161905.8 | 3.188E-8 | 0 | -28022 | gtex_brain_ba24 |
| rs72835643 | 17 | 4573612 | ALOX15 | ENSG00000161905.8 | 2.355E-9 | 0 | -28023 | gtex_brain_ba24 |
| rs72835644 | 17 | 4573667 | ALOX15 | ENSG00000161905.8 | 2.455E-9 | 0 | -28078 | gtex_brain_ba24 |
| rs145842529 | 17 | 4573846 | ALOX15 | ENSG00000161905.8 | 9.185E-9 | 0 | -28257 | gtex_brain_ba24 |
| rs2174830 | 17 | 4573992 | ALOX15 | ENSG00000161905.8 | 3.868E-8 | 0 | -28403 | gtex_brain_ba24 |
| rs8078044 | 17 | 4573994 | ALOX15 | ENSG00000161905.8 | 6.8E-8 | 0 | -28405 | gtex_brain_ba24 |
| rs9436 | 17 | 4574751 | ALOX15 | ENSG00000161905.8 | 9.252E-9 | 0 | -29162 | gtex_brain_ba24 |
| rs55677157 | 17 | 4576620 | ALOX15 | ENSG00000161905.8 | 2.355E-9 | 0 | -31031 | gtex_brain_ba24 |
| rs11658808 | 17 | 4577112 | ALOX15 | ENSG00000161905.8 | 3.188E-8 | 0 | -31523 | gtex_brain_ba24 |
| rs55884013 | 17 | 4579301 | ALOX15 | ENSG00000161905.8 | 9.226E-9 | 0 | -33712 | gtex_brain_ba24 |
| rs8071990 | 17 | 4579638 | ALOX15 | ENSG00000161905.8 | 3.188E-8 | 0 | -34049 | gtex_brain_ba24 |
| rs10775384 | 17 | 4581103 | ALOX15 | ENSG00000161905.8 | 8.694E-8 | 0 | -35514 | gtex_brain_ba24 |
| rs55682338 | 17 | 4582183 | ALOX15 | ENSG00000161905.8 | 8.967E-9 | 0 | -36594 | gtex_brain_ba24 |
| rs9902000 | 17 | 4582426 | ALOX15 | ENSG00000161905.8 | 5.911E-9 | 0 | -36837 | gtex_brain_ba24 |
| rs4790674 | 17 | 4583023 | ALOX15 | ENSG00000161905.8 | 1.011E-7 | 0 | -37434 | gtex_brain_ba24 |
| rs139864929 | 17 | 4584670 | ALOX15 | ENSG00000161905.8 | 9.42E-8 | 0 | -39081 | gtex_brain_ba24 |
| rs12452404 | 17 | 4587355 | ALOX15 | ENSG00000161905.8 | 7.726E-8 | 0 | -41766 | gtex_brain_ba24 |
| rs72824951 | 17 | 4588500 | ALOX15 | ENSG00000161905.8 | 3.997E-8 | 0 | -42911 | gtex_brain_ba24 |
| rs56237051 | 17 | 4589156 | ALOX15 | ENSG00000161905.8 | 3.997E-8 | 0 | -43567 | gtex_brain_ba24 |
| rs55956806 | 17 | 4589209 | ALOX15 | ENSG00000161905.8 | 2.319E-8 | 0 | -43620 | gtex_brain_ba24 |
| rs147867504 | 17 | 4589875 | ALOX15 | ENSG00000161905.8 | 1.341E-7 | 0 | -44286 | gtex_brain_ba24 |
| rs143670032 | 17 | 4590041 | ALOX15 | ENSG00000161905.8 | 1.341E-7 | 0 | -44452 | gtex_brain_ba24 |
| rs140888387 | 17 | 4590088 | ALOX15 | ENSG00000161905.8 | 1.341E-7 | 0 | -44499 | gtex_brain_ba24 |
| rs72824957 | 17 | 4590496 | ALOX15 | ENSG00000161905.8 | 4.006E-8 | 0 | -44907 | gtex_brain_ba24 |
| rs139330508 | 17 | 4591490 | ALOX15 | ENSG00000161905.8 | 4.011E-8 | 0 | -45901 | gtex_brain_ba24 |
| rs146767065 | 17 | 4593115 | ALOX15 | ENSG00000161905.8 | 1.344E-7 | 0 | -47526 | gtex_brain_ba24 |
| rs3947040 | 17 | 4593566 | ALOX15 | ENSG00000161905.8 | 2.237E-7 | 0 | -47977 | gtex_brain_ba24 |
| rs2135911 | 17 | 4593602 | ALOX15 | ENSG00000161905.8 | 2.237E-7 | 0 | -48013 | gtex_brain_ba24 |
| rs7216467 | 17 | 4593867 | ALOX15 | ENSG00000161905.8 | 1.353E-7 | 0 | -48278 | gtex_brain_ba24 |
| rs906453 | 17 | 4594965 | ALOX15 | ENSG00000161905.8 | 7.803E-8 | 0 | -49376 | gtex_brain_ba24 |
| rs55711754 | 17 | 4595488 | ALOX15 | ENSG00000161905.8 | 4.019E-8 | 0 | -49899 | gtex_brain_ba24 |
| rs4790681 | 17 | 4596169 | ALOX15 | ENSG00000161905.8 | 2.242E-7 | 0 | -50580 | gtex_brain_ba24 |
| rs4790682 | 17 | 4596541 | ALOX15 | ENSG00000161905.8 | 2.242E-7 | 0 | -50952 | gtex_brain_ba24 |
| rs72824966 | 17 | 4596679 | ALOX15 | ENSG00000161905.8 | 4.025E-8 | 0 | -51090 | gtex_brain_ba24 |
| rs4438362 | 17 | 4597887 | ALOX15 | ENSG00000161905.8 | 2.246E-7 | 0 | -52298 | gtex_brain_ba24 |
| rs7222305 | 17 | 4598593 | ALOX15 | ENSG00000161905.8 | 4.023E-8 | 0 | -53004 | gtex_brain_ba24 |
| rs56239958 | 17 | 4600280 | ALOX15 | ENSG00000161905.8 | 4.03E-8 | 0 | -54691 | gtex_brain_ba24 |
| rs56104723 | 17 | 4600510 | ALOX15 | ENSG00000161905.8 | 2.319E-8 | 0 | -54921 | gtex_brain_ba24 |
| rs55999196 | 17 | 4600655 | ALOX15 | ENSG00000161905.8 | 4.039E-8 | 0 | -55066 | gtex_brain_ba24 |
| rs56003988 | 17 | 4600764 | ALOX15 | ENSG00000161905.8 | 4.033E-8 | 0 | -55175 | gtex_brain_ba24 |
| rs7214635 | 17 | 4601020 | ALOX15 | ENSG00000161905.8 | 1.965E-8 | 0 | -55431 | gtex_brain_ba24 |
| rs139511077 | 17 | 4601733 | ALOX15 | ENSG00000161905.8 | 4.134E-8 | 0 | -56144 | gtex_brain_ba24 |
| rs4790685 | 17 | 4602515 | ALOX15 | ENSG00000161905.8 | 2.852E-7 | 0 | -56926 | gtex_brain_ba24 |
| rs9891316 | 17 | 4602937 | ALOX15 | ENSG00000161905.8 | 2.405E-7 | 0 | -57348 | gtex_brain_ba24 |
| rs11653940 | 17 | 4603647 | ALOX15 | ENSG00000161905.8 | 9.13E-8 | 0 | -58058 | gtex_brain_ba24 |
| rs12451741 | 17 | 4604030 | ALOX15 | ENSG00000161905.8 | 2.54E-7 | 0 | -58441 | gtex_brain_ba24 |
| rs28662192 | 17 | 4604497 | ALOX15 | ENSG00000161905.8 | 1.153E-7 | 0 | -58908 | gtex_brain_ba24 |
| rs4790687 | 17 | 4604634 | ALOX15 | ENSG00000161905.8 | 2.576E-7 | 0 | -59045 | gtex_brain_ba24 |
| rs9901392 | 17 | 4604836 | ALOX15 | ENSG00000161905.8 | 2.609E-7 | 0 | -59247 | gtex_brain_ba24 |
| rs9894735 | 17 | 4604838 | ALOX15 | ENSG00000161905.8 | 2.61E-7 | 0 | -59249 | gtex_brain_ba24 |
| rs201988837 | 17 | 4604838 | ALOX15 | ENSG00000161905.8 | 2.609E-7 | 0 | -59249 | gtex_brain_ba24 |
| rs4790688 | 17 | 4605068 | ALOX15 | ENSG00000161905.8 | 2.613E-7 | 0 | -59479 | gtex_brain_ba24 |
| rs4790689 | 17 | 4605200 | ALOX15 | ENSG00000161905.8 | 2.624E-7 | 0 | -59611 | gtex_brain_ba24 |
| rs1973555 | 17 | 4605887 | ALOX15 | ENSG00000161905.8 | 2.624E-7 | 0 | -60298 | gtex_brain_ba24 |
| rs12453305 | 17 | 4606395 | ALOX15 | ENSG00000161905.8 | 2.629E-7 | 0 | -60806 | gtex_brain_ba24 |
| rs7225717 | 17 | 4608052 | ALOX15 | ENSG00000161905.8 | 3.215E-7 | 0 | -62463 | gtex_brain_ba24 |
| rs2174831 | 17 | 4608275 | ALOX15 | ENSG00000161905.8 | 3.354E-7 | 0 | -62686 | gtex_brain_ba24 |
| rs7210729 | 17 | 4608389 | ALOX15 | ENSG00000161905.8 | 3.47E-7 | 0 | -62800 | gtex_brain_ba24 |
| rs7215300 | 17 | 4608622 | ALOX15 | ENSG00000161905.8 | 3.528E-7 | 0 | -63033 | gtex_brain_ba24 |
| rs200739390 | 17 | 4608774 | ALOX15 | ENSG00000161905.8 | 1.299E-6 | 0 | -63185 | gtex_brain_ba24 |
| rs60410792 | 17 | 4608777 | ALOX15 | ENSG00000161905.8 | 1.534E-7 | 0 | -63188 | gtex_brain_ba24 |
| rs7210953 | 17 | 4608870 | ALOX15 | ENSG00000161905.8 | 4.605E-8 | 0 | -63281 | gtex_brain_ba24 |
| rs10562310 | 17 | 4608882 | ALOX15 | ENSG00000161905.8 | 3.53E-7 | 0 | -63293 | gtex_brain_ba24 |
| rs61463697 | 17 | 4609422 | ALOX15 | ENSG00000161905.8 | 1.841E-7 | 0 | -63833 | gtex_brain_ba24 |
| rs12601796 | 17 | 4610477 | ALOX15 | ENSG00000161905.8 | 2.626E-7 | 0 | -64888 | gtex_brain_ba24 |
| rs4790692 | 17 | 4611302 | ALOX15 | ENSG00000161905.8 | 1.247E-7 | 0 | -65713 | gtex_brain_ba24 |
| rs9893958 | 17 | 4611388 | ALOX15 | ENSG00000161905.8 | 3.497E-7 | 0 | -65799 | gtex_brain_ba24 |
| rs8065068 | 17 | 4611453 | ALOX15 | ENSG00000161905.8 | 3.508E-7 | 0 | -65864 | gtex_brain_ba24 |
| rs57038129 | 17 | 4611779 | ALOX15 | ENSG00000161905.8 | 4.906E-8 | 0 | -66190 | gtex_brain_ba24 |
| rs55787856 | 17 | 4611786 | ALOX15 | ENSG00000161905.8 | 4.587E-8 | 0 | -66197 | gtex_brain_ba24 |
| rs2326118 | 17 | 4611851 | ALOX15 | ENSG00000161905.8 | 3.494E-7 | 0 | -66262 | gtex_brain_ba24 |
| rs55805626 | 17 | 4612249 | ALOX15 | ENSG00000161905.8 | 3.32E-8 | 0 | -66660 | gtex_brain_ba24 |
| rs8071086 | 17 | 4612866 | ALOX15 | ENSG00000161905.8 | 2.584E-7 | 0 | -67277 | gtex_brain_ba24 |
| rs8069382 | 17 | 4612874 | ALOX15 | ENSG00000161905.8 | 2.591E-7 | 0 | -67285 | gtex_brain_ba24 |
| rs72824977 | 17 | 4612975 | ALOX15 | ENSG00000161905.8 | 3.322E-8 | 0 | -67386 | gtex_brain_ba24 |
| rs34230287 | 17 | 4613630 | ALOX15 | ENSG00000161905.8 | 3.309E-8 | 0 | -68041 | gtex_brain_ba24 |
| rs11868227 | 17 | 4614539 | ALOX15 | ENSG00000161905.8 | 2.121E-7 | 0 | -68950 | gtex_brain_ba24 |
| rs3786047 | 17 | 4615098 | ALOX15 | ENSG00000161905.8 | 3.692E-7 | 0 | -69509 | gtex_brain_ba24 |
| rs35592645 | 17 | 4616387 | ALOX15 | ENSG00000161905.8 | 4.057E-8 | 0 | -70798 | gtex_brain_ba24 |
| rs11324202 | 17 | 4617388 | ALOX15 | ENSG00000161905.8 | 7.299E-7 | 0 | -71799 | gtex_brain_ba24 |
| rs144830084 | 17 | 4618101 | ALOX15 | ENSG00000161905.8 | 6.045E-8 | 0 | -72512 | gtex_brain_ba24 |
| rs35741745 | 17 | 4620897 | ALOX15 | ENSG00000161905.8 | 3.359E-8 | 0 | -75308 | gtex_brain_ba24 |
| rs28365158 | 17 | 4620928 | ALOX15 | ENSG00000161905.8 | 3.363E-8 | 0 | -75339 | gtex_brain_ba24 |
| rs4522461 | 17 | 4621773 | ALOX15 | ENSG00000161905.8 | 2.964E-8 | 0 | -76184 | gtex_brain_ba24 |
| rs34199454 | 17 | 4622203 | ALOX15 | ENSG00000161905.8 | 3.469E-8 | 0 | -76614 | gtex_brain_ba24 |
| rs28365160 | 17 | 4622551 | ALOX15 | ENSG00000161905.8 | 5.494E-8 | 0 | -76962 | gtex_brain_ba24 |
| rs1045280 | 17 | 4622638 | ALOX15 | ENSG00000161905.8 | 6.237E-7 | 0 | -77049 | gtex_brain_ba24 |
| rs2271167 | 17 | 4622880 | ALOX15 | ENSG00000161905.8 | 6.304E-7 | 0 | -77291 | gtex_brain_ba24 |
| rs35980444 | 17 | 4623375 | ALOX15 | ENSG00000161905.8 | 3.548E-8 | 0 | -77786 | gtex_brain_ba24 |
| rs35383686 | 17 | 4623456 | ALOX15 | ENSG00000161905.8 | 6.623E-8 | 0 | -77867 | gtex_brain_ba24 |
| rs9913156 | 17 | 4624966 | ALOX15 | ENSG00000161905.8 | 2.234E-7 | 0 | -79377 | gtex_brain_ba24 |
| rs2036657 | 17 | 4625159 | ALOX15 | ENSG00000161905.8 | 1.044E-6 | 0 | -79570 | gtex_brain_ba24 |
| rs35795124 | 17 | 4625212 | ALOX15 | ENSG00000161905.8 | 1.412E-7 | 0 | -79623 | gtex_brain_ba24 |
| rs71904792 | 17 | 4625568 | ALOX15 | ENSG00000161905.8 | 9.754E-8 | 0 | -79979 | gtex_brain_ba24 |
| rs8068774 | 17 | 4625669 | ALOX15 | ENSG00000161905.8 | 9.752E-8 | 0 | -80080 | gtex_brain_ba24 |
| rs8068781 | 17 | 4625672 | ALOX15 | ENSG00000161905.8 | 9.751E-8 | 0 | -80083 | gtex_brain_ba24 |
| rs8064343 | 17 | 4625758 | ALOX15 | ENSG00000161905.8 | 1.245E-7 | 0 | -80169 | gtex_brain_ba24 |
| rs35045092 | 17 | 4625800 | ALOX15 | ENSG00000161905.8 | 4.18E-7 | 0 | -80211 | gtex_brain_ba24 |
| rs8064504 | 17 | 4625870 | ALOX15 | ENSG00000161905.8 | 1.69E-8 | 0 | -80281 | gtex_brain_ba24 |
| rs35186877 | 17 | 4625892 | ALOX15 | ENSG00000161905.8 | 9.802E-9 | 0 | -80303 | gtex_brain_ba24 |
| rs34625233 | 17 | 4625958 | ALOX15 | ENSG00000161905.8 | 1.738E-7 | 0 | -80369 | gtex_brain_ba24 |
| rs67966027 | 17 | 4626086 | ALOX15 | ENSG00000161905.8 | 9.167E-8 | 0 | -80497 | gtex_brain_ba24 |
| rs36019118 | 17 | 4626220 | ALOX15 | ENSG00000161905.8 | 5.609E-8 | 0 | -80631 | gtex_brain_ba24 |
| rs35552228 | 17 | 4626318 | ALOX15 | ENSG00000161905.8 | 4.863E-7 | 0 | -80729 | gtex_brain_ba24 |
| rs145042193 | 17 | 4626587 | ALOX15 | ENSG00000161905.8 | 5.813E-7 | 0 | -80998 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ANKRD55 | 0.59 | 0.54 |
| CORT | 0.59 | 0.56 |
| APITD1 | 0.57 | 0.49 |
| C5orf40 | 0.57 | 0.60 |
| C4orf44 | 0.55 | 0.43 |
| WNT1 | 0.54 | 0.57 |
| CHRM4 | 0.54 | 0.51 |
| MADCAM1 | 0.54 | 0.38 |
| SECTM1 | 0.53 | 0.50 |
| RXRG | 0.53 | 0.57 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| NEUROD6 | -0.46 | -0.41 |
| ZNF435 | -0.46 | -0.51 |
| COTL1 | -0.45 | -0.48 |
| SNX7 | -0.45 | -0.46 |
| CBS | -0.45 | -0.45 |
| CSRP2 | -0.45 | -0.56 |
| SLA | -0.45 | -0.41 |
| MLLT3 | -0.44 | -0.48 |
| ZEB2 | -0.44 | -0.45 |
| DACT1 | -0.43 | -0.38 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG ARACHIDONIC ACID METABOLISM | 58 | 36 | All SZGR 2.0 genes in this pathway |
| KEGG LINOLEIC ACID METABOLISM | 29 | 16 | All SZGR 2.0 genes in this pathway |
| PID IL4 2PATHWAY | 65 | 43 | All SZGR 2.0 genes in this pathway |
| SENGUPTA NASOPHARYNGEAL CARCINOMA DN | 349 | 157 | All SZGR 2.0 genes in this pathway |
| FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP | 579 | 346 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| GOZGIT ESR1 TARGETS DN | 781 | 465 | All SZGR 2.0 genes in this pathway |
| BENPORATH SUZ12 TARGETS | 1038 | 678 | All SZGR 2.0 genes in this pathway |
| BENPORATH EED TARGETS | 1062 | 725 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES WITH H3K27ME3 | 1118 | 744 | All SZGR 2.0 genes in this pathway |
| BENPORATH PRC2 TARGETS | 652 | 441 | All SZGR 2.0 genes in this pathway |
| BYSTROEM CORRELATED WITH IL5 UP | 51 | 30 | All SZGR 2.0 genes in this pathway |
| NAKAJIMA EOSINOPHIL | 30 | 20 | All SZGR 2.0 genes in this pathway |
| LENAOUR DENDRITIC CELL MATURATION UP | 114 | 84 | All SZGR 2.0 genes in this pathway |
| KUMAR TARGETS OF MLL AF9 FUSION | 405 | 264 | All SZGR 2.0 genes in this pathway |
| KONDO PROSTATE CANCER HCP WITH H3K27ME3 | 97 | 72 | All SZGR 2.0 genes in this pathway |
| LINDSTEDT DENDRITIC CELL MATURATION D | 68 | 44 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MCV6 HCP WITH H3K27ME3 | 435 | 318 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN IPS WITH HCP H3K27ME3 | 102 | 76 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3K27ME3 | 590 | 403 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 15 | 35 | 23 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS UP | 745 | 475 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |