Gene Page: FUS

Summary
GeneID  2521
Symbol  FUS
Synonyms  CHOP|FUS-CHOP|FUS1|TLS|TLS/CHOP|hnRNP-P2
Description  fusion (involved in t(12;16) in malignant liposarcoma)
See related  HGNC:4010|MIM:137070|Ensembl:ENSG00000089280|HPRD:00660|
Locus tag  -
Gene type  protein-coding
Map location  16p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ISG150.980.89
OAS10.940.84
BST20.930.82
IFITM10.920.80
IFI350.890.84
OASL0.880.81
PLA1A0.850.70
TAP10.840.79
PSMB80.840.84
HLA-A0.820.65
Top 10 negatively co-expressed genes
DDX42-0.46-0.63
GGNBP2-0.45-0.61
C14orf102-0.45-0.62
ABCF1-0.45-0.60
USP48-0.45-0.66
IWS1-0.45-0.73
PELP1-0.45-0.68
ANKRD17-0.44-0.66
RNASEN-0.44-0.74
SF3B2-0.44-0.68
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003674molecular_functionND-
GO:0003677DNA bindingIEA-
GO:0003723RNA bindingTAS8510758 
GO:0005515protein bindingIPI9774382 
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000398nuclear mRNA splicing, via spliceosomeEXP12226669 
GO:0008150biological_processND-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005575cellular_componentND-
GO:0005622intracellularIEA-
GO:0005634nucleusTAS8510758 
GO:0005730nucleolusIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EIF62 | CAB | EIF3A | ITGB4BP | b | b(2)gcn | gcn | p27BBPeukaryotic translation initiation factor 6Affinity Capture-MSBioGRID17353931 
FUSIP1FUSIP2 | NSSR | SFRS13 | SRp38 | SRrp40 | TASR | TASR1 | TASR2FUS interacting protein (serine/arginine-rich) 1-HPRD,BioGRID9774382|10779324 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1-HPRD10862698 
ILF3CBTF | DRBF | DRBP76 | MMP4 | MPHOSPH4 | MPP4 | NF-AT-90 | NF110 | NF90 | NFAR | NFAR-1 | NFAR2 | TCP110 | TCP80interleukin enhancer binding factor 3, 90kDa-HPRD,BioGRID11438536 
PRMT1ANM1 | HCP1 | HRMT1L2 | IR1B4protein arginine methyltransferase 1-HPRD,BioGRID11850402 
PTBP1HNRNP-I | HNRNPI | HNRPI | MGC10830 | MGC8461 | PTB | PTB-1 | PTB-T | PTB2 | PTB3 | PTB4 | pPTBpolypyrimidine tract binding protein 1-HPRD12581738 
PTBP2FLJ34897 | PTB | PTBLP | brPTB | nPTB | nPTB5 | nPTB6 | nPTB7 | nPTB8polypyrimidine tract binding protein 2Affinity Capture-WesternBioGRID12581738 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)-HPRD,BioGRID11278855 
RXRAFLJ00280 | FLJ00318 | FLJ16020 | FLJ16733 | MGC102720 | NR2B1retinoid X receptor, alpha-HPRD,BioGRID9440806 
SF1D11S636 | ZFM1 | ZNF162splicing factor 1-HPRD,BioGRID9660765 
SFRS2PR264 | SC-35 | SC35 | SFRS2A | SRp30bsplicing factor, arginine/serine-rich 2-HPRD9774382 
SPI1OF | PU.1 | SFPI1 | SPI-1 | SPI-Aspleen focus forming virus (SFFV) proviral integration oncogene spi1-HPRD,BioGRID9478924 
SRRM1160-KD | MGC39488 | POP101 | SRM160serine/arginine repetitive matrix 1-HPRD,BioGRID12581738 
THRAAR7 | EAR7 | ERB-T-1 | ERBA | ERBA1 | MGC000261 | MGC43240 | NR1A1 | THRA1 | THRA2 | c-ERBA-1thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)-HPRD,BioGRID9440806 
USF2FIP | bHLHb12upstream transcription factor 2, c-fos interactingAffinity Capture-MSBioGRID17353931 
YBX1BP-8 | CSDA2 | CSDB | DBPB | MDR-NF1 | MGC104858 | MGC110976 | MGC117250 | NSEP-1 | NSEP1 | YB-1 | YB1Y box binding protein 1-HPRD,BioGRID12168660 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 14077All SZGR genes in this pathway
REACTOME_MRNA_PROCESSING 16186All SZGR genes in this pathway
REACTOME_MRNA_SPLICING 11158All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
HOOI_ST7_TARGETS_DN 12378All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_UP 380215All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_DN 13976All SZGR genes in this pathway
ODONNELL_TARGETS_OF_MYC_AND_TFRC_DN 4525All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP 457269All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
ELVIDGE_HYPOXIA_DN 14694All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_5_6WK_DN 13797All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
ALCALA_APOPTOSIS 8860All SZGR genes in this pathway
FALVELLA_SMOKERS_WITH_LUNG_CANCER 8052All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_MODERATELY_VS_POORLY_UP 12171All SZGR genes in this pathway
PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_DN 165104All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_NOS_TARGETS 179105All SZGR genes in this pathway
MANALO_HYPOXIA_DN 289166All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_DN 337230All SZGR genes in this pathway
AFFAR_YY1_TARGETS_DN 234137All SZGR genes in this pathway
MARIADASON_RESPONSE_TO_CURCUMIN_SULINDAC_5 2317All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C 463262All SZGR genes in this pathway
MATZUK_SPERMATOCYTE 7255All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_UP 13995All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
LIU_VAV3_PROSTATE_CARCINOGENESIS_UP 8961All SZGR genes in this pathway
FONTAINE_PAPILLARY_THYROID_CARCINOMA_UP 6638All SZGR genes in this pathway
CHANDRAN_METASTASIS_UP 221135All SZGR genes in this pathway
KYNG_RESPONSE_TO_H2O2_VIA_ERCC6_DN 4631All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_1_DN 6339All SZGR genes in this pathway
KATSANOU_ELAVL1_TARGETS_DN 14888All SZGR genes in this pathway
GUO_TARGETS_OF_IRS1_AND_IRS2 9867All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-141/200a46531A,m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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