Gene Page: SNX32
Summary ?
| GeneID | 254122 |
| Symbol | SNX32 |
| Synonyms | SNX6B |
| Description | sorting nexin 32 |
| Reference | HGNC:HGNC:26423|Ensembl:ENSG00000172803|HPRD:08090|Vega:OTTHUMG00000128491 |
| Gene type | protein-coding |
| Map location | 11q13.1 |
| Pascal p-value | 0.116 |
| Sherlock p-value | 0.87 |
| Fetal beta | -1.151 |
| DMG | 1 (# studies) |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg22959820 | 11 | 65601167 | SNX32 | 9.53E-5 | -0.372 | 0.027 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs9726422 | chr1 | 221604979 | SNX32 | 254122 | 0.2 | trans | ||
| rs10806654 | chr6 | 169218995 | SNX32 | 254122 | 0.11 | trans | ||
| rs111953392 | 11 | 65595697 | SNX32 | ENSG00000172803.13 | 1.598E-9 | 0 | -5415 | gtex_brain_ba24 |
| rs77779142 | 11 | 65599656 | SNX32 | ENSG00000172803.13 | 1.598E-9 | 0 | -1456 | gtex_brain_ba24 |
| rs17854357 | 11 | 65601560 | SNX32 | ENSG00000172803.13 | 1.069E-10 | 0 | 448 | gtex_brain_ba24 |
| rs397723867 | 11 | 65621293 | SNX32 | ENSG00000172803.13 | 3.206E-7 | 0 | 20181 | gtex_brain_ba24 |
| rs668356 | 11 | 65621487 | SNX32 | ENSG00000172803.13 | 9.231E-7 | 0 | 20375 | gtex_brain_ba24 |
| rs635375 | 11 | 65621995 | SNX32 | ENSG00000172803.13 | 7.677E-7 | 0 | 20883 | gtex_brain_ba24 |
| rs652021 | 11 | 65623347 | SNX32 | ENSG00000172803.13 | 7.677E-7 | 0 | 22235 | gtex_brain_ba24 |
| rs4621 | 11 | 65623519 | SNX32 | ENSG00000172803.13 | 7.677E-7 | 0 | 22407 | gtex_brain_ba24 |
| rs11227332 | 11 | 65623739 | SNX32 | ENSG00000172803.13 | 2.954E-9 | 0 | 22627 | gtex_brain_ba24 |
| rs665306 | 11 | 65624025 | SNX32 | ENSG00000172803.13 | 7.677E-7 | 0 | 22913 | gtex_brain_ba24 |
| rs667555 | 11 | 65624562 | SNX32 | ENSG00000172803.13 | 5.743E-7 | 0 | 23450 | gtex_brain_ba24 |
| rs7125986 | 11 | 65624934 | SNX32 | ENSG00000172803.13 | 6.925E-7 | 0 | 23822 | gtex_brain_ba24 |
| rs7947929 | 11 | 65625191 | SNX32 | ENSG00000172803.13 | 8.568E-7 | 0 | 24079 | gtex_brain_ba24 |
| rs7947741 | 11 | 65625237 | SNX32 | ENSG00000172803.13 | 4.136E-7 | 0 | 24125 | gtex_brain_ba24 |
| rs508548 | 11 | 65626539 | SNX32 | ENSG00000172803.13 | 7.677E-7 | 0 | 25427 | gtex_brain_ba24 |
| rs13817 | 11 | 65628334 | SNX32 | ENSG00000172803.13 | 7.677E-7 | 0 | 27222 | gtex_brain_ba24 |
| rs659857 | 11 | 65629932 | SNX32 | ENSG00000172803.13 | 7.967E-7 | 0 | 28820 | gtex_brain_ba24 |
| rs545500 | 11 | 65629934 | SNX32 | ENSG00000172803.13 | 7.967E-7 | 0 | 28822 | gtex_brain_ba24 |
| rs633877 | 11 | 65630101 | SNX32 | ENSG00000172803.13 | 8.044E-7 | 0 | 28989 | gtex_brain_ba24 |
| rs538394 | 11 | 65630698 | SNX32 | ENSG00000172803.13 | 7.677E-7 | 0 | 29586 | gtex_brain_ba24 |
| rs648732 | 11 | 65631167 | SNX32 | ENSG00000172803.13 | 7.677E-7 | 0 | 30055 | gtex_brain_ba24 |
| rs630758 | 11 | 65631879 | SNX32 | ENSG00000172803.13 | 7.495E-7 | 0 | 30767 | gtex_brain_ba24 |
| rs630755 | 11 | 65631881 | SNX32 | ENSG00000172803.13 | 7.495E-7 | 0 | 30769 | gtex_brain_ba24 |
| rs630303 | 11 | 65631973 | SNX32 | ENSG00000172803.13 | 7.677E-7 | 0 | 30861 | gtex_brain_ba24 |
| rs558114 | 11 | 65632262 | SNX32 | ENSG00000172803.13 | 7.677E-7 | 0 | 31150 | gtex_brain_ba24 |
| rs11227333 | 11 | 65642417 | SNX32 | ENSG00000172803.13 | 9.096E-9 | 0 | 41305 | gtex_brain_ba24 |
| rs583887 | 11 | 65644027 | SNX32 | ENSG00000172803.13 | 1.599E-7 | 0 | 42915 | gtex_brain_ba24 |
| rs679147 | 11 | 65644363 | SNX32 | ENSG00000172803.13 | 3.157E-7 | 0 | 43251 | gtex_brain_ba24 |
| rs596002 | 11 | 65645354 | SNX32 | ENSG00000172803.13 | 7.051E-7 | 0 | 44242 | gtex_brain_ba24 |
| rs1204650 | 11 | 65645580 | SNX32 | ENSG00000172803.13 | 1.599E-7 | 0 | 44468 | gtex_brain_ba24 |
| rs1151519 | 11 | 65645831 | SNX32 | ENSG00000172803.13 | 1.599E-7 | 0 | 44719 | gtex_brain_ba24 |
| rs601863 | 11 | 65646557 | SNX32 | ENSG00000172803.13 | 1.599E-7 | 0 | 45445 | gtex_brain_ba24 |
| rs12225345 | 11 | 65647105 | SNX32 | ENSG00000172803.13 | 2.216E-8 | 0 | 45993 | gtex_brain_ba24 |
| rs658524 | 11 | 65647260 | SNX32 | ENSG00000172803.13 | 1.599E-7 | 0 | 46148 | gtex_brain_ba24 |
| rs645900 | 11 | 65648135 | SNX32 | ENSG00000172803.13 | 1.599E-7 | 0 | 47023 | gtex_brain_ba24 |
| rs687672 | 11 | 65649984 | SNX32 | ENSG00000172803.13 | 1.599E-7 | 0 | 48872 | gtex_brain_ba24 |
| rs658938 | 11 | 65651830 | SNX32 | ENSG00000172803.13 | 1.599E-7 | 0 | 50718 | gtex_brain_ba24 |
| rs568617 | 11 | 65653242 | SNX32 | ENSG00000172803.13 | 1.599E-7 | 0 | 52130 | gtex_brain_ba24 |
| rs694994 | 11 | 65653309 | SNX32 | ENSG00000172803.13 | 1.599E-7 | 0 | 52197 | gtex_brain_ba24 |
| rs677931 | 11 | 65654665 | SNX32 | ENSG00000172803.13 | 1.536E-7 | 0 | 53553 | gtex_brain_ba24 |
| rs693824 | 11 | 65654783 | SNX32 | ENSG00000172803.13 | 1.599E-7 | 0 | 53671 | gtex_brain_ba24 |
| rs641018 | 11 | 65655393 | SNX32 | ENSG00000172803.13 | 1.599E-7 | 0 | 54281 | gtex_brain_ba24 |
| rs656980 | 11 | 65656282 | SNX32 | ENSG00000172803.13 | 1.599E-7 | 0 | 55170 | gtex_brain_ba24 |
| rs2231884 | 11 | 65656564 | SNX32 | ENSG00000172803.13 | 1.108E-10 | 0 | 55452 | gtex_brain_ba24 |
| rs10791830 | 11 | 65661291 | SNX32 | ENSG00000172803.13 | 4.929E-8 | 0 | 60179 | gtex_brain_ba24 |
| rs507062 | 11 | 65661656 | SNX32 | ENSG00000172803.13 | 7.663E-7 | 0 | 60544 | gtex_brain_ba24 |
| rs201407003 | 11 | 65662435 | SNX32 | ENSG00000172803.13 | 1.495E-8 | 0 | 61323 | gtex_brain_ba24 |
| rs608616 | 11 | 65662436 | SNX32 | ENSG00000172803.13 | 2.269E-6 | 0 | 61324 | gtex_brain_ba24 |
| rs588114 | 11 | 65662752 | SNX32 | ENSG00000172803.13 | 7.663E-7 | 0 | 61640 | gtex_brain_ba24 |
| rs58568715 | 11 | 65662985 | SNX32 | ENSG00000172803.13 | 1.004E-10 | 0 | 61873 | gtex_brain_ba24 |
| rs622614 | 11 | 65663239 | SNX32 | ENSG00000172803.13 | 4.236E-8 | 0 | 62127 | gtex_brain_ba24 |
| rs585557 | 11 | 65663547 | SNX32 | ENSG00000172803.13 | 5.509E-7 | 0 | 62435 | gtex_brain_ba24 |
| rs56252769 | 11 | 65718633 | SNX32 | ENSG00000172803.13 | 1.294E-6 | 0 | 117521 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PEREZ TP53 TARGETS | 1174 | 695 | All SZGR 2.0 genes in this pathway |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | 517 | 309 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3K4ME2 | 491 | 319 | All SZGR 2.0 genes in this pathway |