Gene Page: TBC1D22A
Summary ?
| GeneID | 25771 |
| Symbol | TBC1D22A |
| Synonyms | C22orf4|HSC79E021 |
| Description | TBC1 domain family member 22A |
| Reference | HGNC:HGNC:1309|Ensembl:ENSG00000054611|HPRD:15474|Vega:OTTHUMG00000150332 |
| Gene type | protein-coding |
| Map location | 22q13.3 |
| Pascal p-value | 0.681 |
| Sherlock p-value | 0.279 |
| Fetal beta | -1.15 |
| eGene | Nucleus accumbens basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MCM5 | 0.84 | 0.70 |
| LLGL1 | 0.84 | 0.83 |
| FZD2 | 0.83 | 0.50 |
| TP53 | 0.83 | 0.57 |
| DPF2 | 0.82 | 0.77 |
| SFRP1 | 0.82 | 0.73 |
| ACTL6A | 0.82 | 0.72 |
| PCNA | 0.81 | 0.62 |
| ARL6IP6 | 0.81 | 0.59 |
| CHST14 | 0.81 | 0.59 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CXCL14 | -0.40 | -0.48 |
| CARD16 | -0.38 | -0.52 |
| MT-CO2 | -0.38 | -0.41 |
| PTH1R | -0.37 | -0.38 |
| AF347015.21 | -0.37 | -0.48 |
| AF347015.31 | -0.37 | -0.40 |
| AF347015.8 | -0.36 | -0.40 |
| AF347015.27 | -0.36 | -0.39 |
| IFI27 | -0.36 | -0.40 |
| C5orf53 | -0.36 | -0.34 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PARENT MTOR SIGNALING UP | 567 | 375 | All SZGR 2.0 genes in this pathway |
| FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP | 579 | 346 | All SZGR 2.0 genes in this pathway |
| KINSEY TARGETS OF EWSR1 FLII FUSION DN | 329 | 219 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| MARKEY RB1 ACUTE LOF UP | 215 | 137 | All SZGR 2.0 genes in this pathway |
| RICKMAN METASTASIS DN | 261 | 155 | All SZGR 2.0 genes in this pathway |
| KOYAMA SEMA3B TARGETS DN | 411 | 249 | All SZGR 2.0 genes in this pathway |
| YOSHIOKA LIVER CANCER EARLY RECURRENCE DN | 65 | 31 | All SZGR 2.0 genes in this pathway |
| STAMBOLSKY TARGETS OF MUTATED TP53 DN | 50 | 24 | All SZGR 2.0 genes in this pathway |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | All SZGR 2.0 genes in this pathway |