Summary ?
GeneID25778
SymbolDSTYK
SynonymsCAKUT1|DustyPK|HDCMD38P|RIP5|RIPK5
Descriptiondual serine/threonine and tyrosine protein kinase
ReferenceMIM:612666|HGNC:HGNC:29043|Ensembl:ENSG00000133059|HPRD:11495|Vega:OTTHUMG00000037102
Gene typeprotein-coding
Map location1q32.1
Sherlock p-value0.18
Fetal beta-0.717
eGeneCaudate basal ganglia
Frontal Cortex BA9
Hippocampus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs31452chr516929982DSTYK257780.18trans
rs49509781205024573DSTYKENSG00000133059.124.094E-60.01156154gtex_brain_putamen_basal
rs1126731451205049371DSTYKENSG00000133059.126.167E-70.01131356gtex_brain_putamen_basal
rs112403521205051711DSTYKENSG00000133059.124.644E-70.01129016gtex_brain_putamen_basal
rs75207521205054114DSTYKENSG00000133059.126.167E-70.01126613gtex_brain_putamen_basal
rs121393731205054879DSTYKENSG00000133059.126.08E-70.01125848gtex_brain_putamen_basal
rs11303111205056525DSTYKENSG00000133059.126.85E-70.01124202gtex_brain_putamen_basal
rs101588481205061192DSTYKENSG00000133059.126.25E-70.01119535gtex_brain_putamen_basal
rs115768671205064676DSTYKENSG00000133059.126.189E-70.01116051gtex_brain_putamen_basal
rs112403551205065298DSTYKENSG00000133059.126.178E-70.01115429gtex_brain_putamen_basal
rs115774061205065733DSTYKENSG00000133059.126.167E-70.01114994gtex_brain_putamen_basal
rs65939221205071167DSTYKENSG00000133059.126.221E-70.01109560gtex_brain_putamen_basal
rs37381551205074424DSTYKENSG00000133059.122.686E-70.01106303gtex_brain_putamen_basal
rs121254651205074854DSTYKENSG00000133059.126.502E-70.01105873gtex_brain_putamen_basal
rs1129433861205075707DSTYKENSG00000133059.126.57E-70.01105020gtex_brain_putamen_basal
rs618225651205077332DSTYKENSG00000133059.126.718E-70.01103395gtex_brain_putamen_basal
rs618225671205078725DSTYKENSG00000133059.126.849E-70.01102002gtex_brain_putamen_basal
rs727575121205079203DSTYKENSG00000133059.126.896E-70.01101524gtex_brain_putamen_basal
rs1126538541205079251DSTYKENSG00000133059.126.85E-70.01101476gtex_brain_putamen_basal
rs618225681205081166DSTYKENSG00000133059.127.092E-70.0199561gtex_brain_putamen_basal
rs1995181381205082818DSTYKENSG00000133059.127.274E-70.0197909gtex_brain_putamen_basal
rs610365851205082819DSTYKENSG00000133059.127.274E-70.0197908gtex_brain_putamen_basal
rs122397121205082976DSTYKENSG00000133059.127.29E-70.0197751gtex_brain_putamen_basal
rs112403601205083865DSTYKENSG00000133059.123.167E-70.0196862gtex_brain_putamen_basal
rs727575241205086473DSTYKENSG00000133059.127.422E-70.0194254gtex_brain_putamen_basal
rs618226191205090885DSTYKENSG00000133059.123.172E-70.0189842gtex_brain_putamen_basal
rs173445371205091427DSTYKENSG00000133059.129.922E-70.0189300gtex_brain_putamen_basal
rs2003907441205092520DSTYKENSG00000133059.126.159E-70.0188207gtex_brain_putamen_basal
rs580618071205092522DSTYKENSG00000133059.124.149E-70.0188205gtex_brain_putamen_basal
rs121303841205105981DSTYKENSG00000133059.121.279E-60.0174746gtex_brain_putamen_basal
rs40921411205108083DSTYKENSG00000133059.122.905E-70.0172644gtex_brain_putamen_basal
rs43947151205108393DSTYKENSG00000133059.123.155E-70.0172334gtex_brain_putamen_basal
rs28361205111761DSTYKENSG00000133059.124.089E-70.0168966gtex_brain_putamen_basal
rs112403691205115099DSTYKENSG00000133059.126.563E-70.0165628gtex_brain_putamen_basal
rs112403701205118336DSTYKENSG00000133059.127.859E-70.0162391gtex_brain_putamen_basal
rs618226261205118441DSTYKENSG00000133059.126.563E-70.0162286gtex_brain_putamen_basal
rs121237731205122420DSTYKENSG00000133059.129.232E-70.0158307gtex_brain_putamen_basal
rs1136995331205122895DSTYKENSG00000133059.121E-60.0157832gtex_brain_putamen_basal
rs121239221205140436DSTYKENSG00000133059.122.088E-60.0140291gtex_brain_putamen_basal
rs618226591205142847DSTYKENSG00000133059.122.055E-60.0137880gtex_brain_putamen_basal
rs115792201205144363DSTYKENSG00000133059.122.09E-60.0136364gtex_brain_putamen_basal
rs66927061205158561DSTYKENSG00000133059.127.943E-70.0122166gtex_brain_putamen_basal
rs719174681205164254DSTYKENSG00000133059.121.118E-60.0116473gtex_brain_putamen_basal
rs1479577411205171245DSTYKENSG00000133059.127.942E-70.019482gtex_brain_putamen_basal
rs601594621205179563DSTYKENSG00000133059.128.043E-70.011164gtex_brain_putamen_basal
rs173451531205179997DSTYKENSG00000133059.128.038E-70.01730gtex_brain_putamen_basal
rs121431211205199142DSTYKENSG00000133059.121.923E-60.01-18415gtex_brain_putamen_basal
rs7480121205216573DSTYKENSG00000133059.122.926E-60.01-35846gtex_brain_putamen_basal
rs11517861205227760DSTYKENSG00000133059.121.674E-60.01-47033gtex_brain_putamen_basal
rs1133060451205230498DSTYKENSG00000133059.122.081E-60.01-49771gtex_brain_putamen_basal
rs11517851205232299DSTYKENSG00000133059.122.743E-60.01-51572gtex_brain_putamen_basal
rs11517841205232447DSTYKENSG00000133059.122.793E-60.01-51720gtex_brain_putamen_basal
rs11807211205232696DSTYKENSG00000133059.122.8E-60.01-51969gtex_brain_putamen_basal
rs11721111205232980DSTYKENSG00000133059.122.806E-60.01-52253gtex_brain_putamen_basal
rs73679301205235512DSTYKENSG00000133059.122.9E-60.01-54785gtex_brain_putamen_basal
rs16688731205235990DSTYKENSG00000133059.122.92E-60.01-55263gtex_brain_putamen_basal
rs16688721205236069DSTYKENSG00000133059.122.923E-60.01-55342gtex_brain_putamen_basal
rs17685871205236432DSTYKENSG00000133059.122.929E-60.01-55705gtex_brain_putamen_basal
rs17685861205238275DSTYKENSG00000133059.122.933E-60.01-57548gtex_brain_putamen_basal
rs17794111205238530DSTYKENSG00000133059.122.937E-60.01-57803gtex_brain_putamen_basal
rs16688701205239031DSTYKENSG00000133059.122.935E-60.01-58304gtex_brain_putamen_basal
rs353443211205239185DSTYKENSG00000133059.122.936E-60.01-58458gtex_brain_putamen_basal
rs16688691205239779DSTYKENSG00000133059.122.941E-60.01-59052gtex_brain_putamen_basal
rs16688671205240251DSTYKENSG00000133059.123.264E-60.01-59524gtex_brain_putamen_basal
rs49511841205240659DSTYKENSG00000133059.122.938E-60.01-59932gtex_brain_putamen_basal
rs11721381205246019DSTYKENSG00000133059.122.978E-60.01-65292gtex_brain_putamen_basal
rs11721371205246061DSTYKENSG00000133059.122.493E-60.01-65334gtex_brain_putamen_basal
rs11721361205247097DSTYKENSG00000133059.123.074E-60.01-66370gtex_brain_putamen_basal
rs11721351205247160DSTYKENSG00000133059.121.204E-60.01-66433gtex_brain_putamen_basal
rs562848551205247315DSTYKENSG00000133059.122.485E-60.01-66588gtex_brain_putamen_basal
rs17794101205248759DSTYKENSG00000133059.124.618E-70.01-68032gtex_brain_putamen_basal
rs16688641205248799DSTYKENSG00000133059.123.269E-60.01-68072gtex_brain_putamen_basal
rs16688631205248917DSTYKENSG00000133059.124.574E-70.01-68190gtex_brain_putamen_basal
rs96609921205249450DSTYKENSG00000133059.124.469E-70.01-68723gtex_brain_putamen_basal
rs556718241205249814DSTYKENSG00000133059.123.407E-60.01-69087gtex_brain_putamen_basal
rs556739461205250475DSTYKENSG00000133059.121.764E-60.01-69748gtex_brain_putamen_basal
rs120924921205251880DSTYKENSG00000133059.121.893E-60.01-71153gtex_brain_putamen_basal
rs727452071205251991DSTYKENSG00000133059.123.765E-60.01-71264gtex_brain_putamen_basal
rs38512961205253839DSTYKENSG00000133059.126.052E-70.01-73112gtex_brain_putamen_basal
rs11517871205254238DSTYKENSG00000133059.124.238E-60.01-73511gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATP5F1MGC24431 | PIG47ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1Affinity Capture-MSBioGRID17353931 
DDTDDCTD-dopachrome tautomeraseAffinity Capture-MSBioGRID17353931 
HSPE1CPN10 | GROES | HSP10heat shock 10kDa protein 1 (chaperonin 10)Affinity Capture-MSBioGRID17353931 
IKBKEIKK-i | IKKE | IKKI | KIAA0151 | MGC125294 | MGC125295 | MGC125297inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilonAffinity Capture-MSBioGRID17353931 
LSM12FLJ30656 | MGC104211 | PNAS-135LSM12 homolog (S. cerevisiae)Affinity Capture-MSBioGRID17353931 
MAD2L1HSMAD2 | MAD2MAD2 mitotic arrest deficient-like 1 (yeast)Affinity Capture-MSBioGRID17353931 
MTPNFLJ31098 | FLJ99857 | GCDP | V-1myotrophinAffinity Capture-MSBioGRID17353931 
PSMB1FLJ25321 | HC5 | KIAA1838 | PMSB1 | PSC5proteasome (prosome, macropain) subunit, beta type, 1Affinity Capture-MSBioGRID17353931 
PSMB3HC10-II | MGC4147proteasome (prosome, macropain) subunit, beta type, 3Affinity Capture-MSBioGRID17353931 
RAB14FBP | RAB-14RAB14, member RAS oncogene familyAffinity Capture-MSBioGRID17353931 
RAB5CMGC117217 | MGC138857 | RAB5CL | RABLRAB5C, member RAS oncogene familyAffinity Capture-MSBioGRID17353931 
RPS9-ribosomal protein S9Affinity Capture-MSBioGRID17353931 
UBE2KDKFZp564C1216 | DKFZp686J24237 | E2-25K | HIP2 | HYPG | LIGubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)Affinity Capture-MSBioGRID17353931 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233161All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
GOTTWEIN TARGETS OF KSHV MIR K12 11 6345All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS UP 214133All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543317All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593372All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591366All SZGR 2.0 genes in this pathway
CHEN LIVER METABOLISM QTL CIS 9340All SZGR 2.0 genes in this pathway