Gene Page: CIZ1
Summary ?
| GeneID | 25792 |
| Symbol | CIZ1 |
| Synonyms | LSFR1|NP94|ZNF356 |
| Description | CDKN1A interacting zinc finger protein 1 |
| Reference | MIM:611420|HGNC:HGNC:16744|Ensembl:ENSG00000148337|HPRD:13061|Vega:OTTHUMG00000020735 |
| Gene type | protein-coding |
| Map location | 9q34.1 |
| Pascal p-value | 0.029 |
| Sherlock p-value | 0.147 |
| eGene | Cerebellum Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg14409940 | 9 | 130967820 | CIZ1;DNM1 | 2.485E-4 | 0.432 | 0.037 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs1507047 | chr16 | 50932778 | CIZ1 | 25792 | 0.12 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| BRWD3 | 0.93 | 0.91 |
| ANP32A | 0.90 | 0.89 |
| ZNF714 | 0.88 | 0.90 |
| HNRNPA1P2 | 0.88 | 0.79 |
| CSGALNACT2 | 0.88 | 0.90 |
| RSL1D1 | 0.88 | 0.82 |
| USP3 | 0.88 | 0.77 |
| ZNF431 | 0.88 | 0.86 |
| C16orf87 | 0.88 | 0.87 |
| SET | 0.87 | 0.88 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| TNFSF12 | -0.63 | -0.70 |
| HLA-F | -0.62 | -0.79 |
| AIFM3 | -0.61 | -0.77 |
| PTH1R | -0.61 | -0.75 |
| TSC22D4 | -0.60 | -0.81 |
| C5orf53 | -0.60 | -0.73 |
| SLC16A11 | -0.60 | -0.69 |
| RAMP1 | -0.59 | -0.80 |
| AF347015.31 | -0.59 | -0.85 |
| LHPP | -0.59 | -0.62 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| LAU APOPTOSIS CDKN2A UP | 55 | 40 | All SZGR 2.0 genes in this pathway |
| AMIT SERUM RESPONSE 120 MCF10A | 65 | 44 | All SZGR 2.0 genes in this pathway |
| PARK HSC AND MULTIPOTENT PROGENITORS | 50 | 33 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| BILD E2F3 ONCOGENIC SIGNATURE | 246 | 153 | All SZGR 2.0 genes in this pathway |
| STEIN ESRRA TARGETS DN | 105 | 63 | All SZGR 2.0 genes in this pathway |
| STEIN ESRRA TARGETS | 535 | 325 | All SZGR 2.0 genes in this pathway |
| CAIRO HEPATOBLASTOMA CLASSES UP | 605 | 377 | All SZGR 2.0 genes in this pathway |
| FOSTER KDM1A TARGETS DN | 211 | 119 | All SZGR 2.0 genes in this pathway |