Gene Page: BRI3
Summary ?
| GeneID | 25798 |
| Symbol | BRI3 |
| Synonyms | I3 |
| Description | brain protein I3 |
| Reference | MIM:615628|HGNC:HGNC:1109|Ensembl:ENSG00000164713|HPRD:16562|Vega:OTTHUMG00000154275 |
| Gene type | protein-coding |
| Map location | 7q21.3 |
| Pascal p-value | 0.244 |
| Fetal beta | 0.27 |
| DMG | 1 (# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Nishioka_2013 | Genome-wide DNA methylation analysis | The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg14640481 | 7 | 97910728 | BRI3 | -0.024 | 0.7 | DMG:Nishioka_2013 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| RAB11FIP2 | 0.93 | 0.93 |
| DMXL2 | 0.92 | 0.92 |
| AKAP11 | 0.92 | 0.92 |
| FBXL17 | 0.92 | 0.92 |
| CLTC | 0.91 | 0.92 |
| OPA1 | 0.91 | 0.90 |
| COL4A3BP | 0.91 | 0.91 |
| UBR3 | 0.91 | 0.91 |
| DMXL1 | 0.90 | 0.88 |
| ATP6V1A | 0.90 | 0.90 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| EIF4EBP3 | -0.58 | -0.66 |
| FXYD1 | -0.55 | -0.58 |
| AF347015.21 | -0.54 | -0.56 |
| ACSF2 | -0.53 | -0.61 |
| MT-CO2 | -0.52 | -0.58 |
| AP002478.3 | -0.52 | -0.60 |
| TLCD1 | -0.52 | -0.55 |
| C1orf61 | -0.52 | -0.68 |
| GSDMD | -0.52 | -0.57 |
| PLA2G5 | -0.51 | -0.57 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| BERENJENO TRANSFORMED BY RHOA DN | 394 | 258 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS UP | 1037 | 673 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT 48HR UP | 487 | 286 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 7Q21 Q22 AMPLICON | 76 | 33 | All SZGR 2.0 genes in this pathway |
| UEDA PERIFERAL CLOCK | 169 | 111 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 UP | 430 | 288 | All SZGR 2.0 genes in this pathway |