Gene Page: PRKD2

Summary ?
GeneID25865
SymbolPRKD2
SynonymsHSPC187|PKD2|nPKC-D2
Descriptionprotein kinase D2
ReferenceMIM:607074|HGNC:HGNC:17293|Ensembl:ENSG00000105287|HPRD:09523|Vega:OTTHUMG00000183431
Gene typeprotein-coding
Map location19q13.3
Pascal p-value0.2
Sherlock p-value0.494
Fetal beta0.349
DMG1 (# studies)
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Cerebellum
Cortex
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg271193581947217696PRKD21.449E-4-0.4980.031DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10282425chr7129831082PRKD2258650.08trans
rs124618481947174893PRKD2ENSG00000105287.86.589E-10045491gtex_brain_ba24
rs8744621947176880PRKD2ENSG00000105287.86.516E-10043504gtex_brain_ba24
rs621347801947188303PRKD2ENSG00000105287.86.532E-10032081gtex_brain_ba24
rs621347811947188810PRKD2ENSG00000105287.86.516E-10031574gtex_brain_ba24
rs621347821947205419PRKD2ENSG00000105287.86.321E-7014965gtex_brain_ba24
rs621347831947206956PRKD2ENSG00000105287.83.814E-7013428gtex_brain_ba24
rs110838461947207654PRKD2ENSG00000105287.82.431E-7012730gtex_brain_ba24
rs1175795061947209159PRKD2ENSG00000105287.83.88E-7011225gtex_brain_ba24
rs124616661947217113PRKD2ENSG00000105287.84.144E-703271gtex_brain_ba24
rs621347881947217587PRKD2ENSG00000105287.84.167E-702797gtex_brain_ba24
rs116689871947227821PRKD2ENSG00000105287.87.579E-70-7437gtex_brain_ba24
rs32150871947230393PRKD2ENSG00000105287.84.57E-70-10009gtex_brain_ba24
rs621347901947237551PRKD2ENSG00000105287.84.071E-70-17167gtex_brain_ba24
rs563746201947241599PRKD2ENSG00000105287.83.514E-70-21215gtex_brain_ba24
rs48023221947242992PRKD2ENSG00000105287.81.608E-70-22608gtex_brain_ba24
rs116685631947243621PRKD2ENSG00000105287.82.611E-70-23237gtex_brain_ba24
rs788873751947247141PRKD2ENSG00000105287.81.823E-70-26757gtex_brain_ba24
rs72587821947247781PRKD2ENSG00000105287.81.669E-70-27397gtex_brain_ba24
rs37867081947248308PRKD2ENSG00000105287.82.023E-70-27924gtex_brain_ba24
rs621347931947248585PRKD2ENSG00000105287.81.663E-70-28201gtex_brain_ba24
rs621348201947256344PRKD2ENSG00000105287.83.586E-70-35960gtex_brain_ba24
rs601042661947257202PRKD2ENSG00000105287.89.667E-80-36818gtex_brain_ba24
rs72490391947266635PRKD2ENSG00000105287.88.294E-90-46251gtex_brain_ba24
rs124590581947274138PRKD2ENSG00000105287.83.608E-70-53754gtex_brain_ba24
rs16443391947281255PRKD2ENSG00000105287.88.244E-70-60871gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP 450256All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP 456228All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGLL VS IGLK DN 2418All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS DN 10563All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA AND UV RADIATION 8865All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195135All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION 175125All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP 298174All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 10 3322All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535325All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237159All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL 162122All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN 213127All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430288All SZGR 2.0 genes in this pathway