Summary ?
GeneID25870
SymbolSUMF2
SynonymspFGE
Descriptionsulfatase modifying factor 2
ReferenceMIM:607940|HGNC:HGNC:20415|Ensembl:ENSG00000129103|HPRD:06400|Vega:OTTHUMG00000129373
Gene typeprotein-coding
Map location7q11.1
Pascal p-value0.025
Sherlock p-value0.744
Fetal beta1.062
DMG2 (# studies)
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 2
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg26790897756147772SUMF21.384E-4-0.5780.031DMG:Wockner_2014
cg23839680756118238SUMF24.76E-54.424DMG:vanEijk_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs802402chr790615513SUMF2258700.02trans
rs35791463756071490SUMF2ENSG00000129103.131.814E-60.01-60205gtex_brain_ba24
rs28438587756073544SUMF2ENSG00000129103.134.181E-70.01-58151gtex_brain_ba24
rs12154781756074020SUMF2ENSG00000129103.134.089E-70.01-57675gtex_brain_ba24
rs12155441756074118SUMF2ENSG00000129103.134.076E-70.01-57577gtex_brain_ba24
rs6970842756077235SUMF2ENSG00000129103.133.988E-70.01-54460gtex_brain_ba24
rs73140779756089807SUMF2ENSG00000129103.138.687E-70.01-41888gtex_brain_ba24
rs55940597756090668SUMF2ENSG00000129103.131.122E-60.01-41027gtex_brain_ba24
rs10265826756091622SUMF2ENSG00000129103.137.289E-70.01-40073gtex_brain_ba24
rs10274148756093454SUMF2ENSG00000129103.137.298E-70.01-38241gtex_brain_ba24
rs73140793756105326SUMF2ENSG00000129103.137.397E-70.01-26369gtex_brain_ba24
rs73140794756105378SUMF2ENSG00000129103.137.397E-70.01-26317gtex_brain_ba24
rs59723101756106166SUMF2ENSG00000129103.137.403E-70.01-25529gtex_brain_ba24
rs113152440756106308SUMF2ENSG00000129103.137.404E-70.01-25387gtex_brain_ba24
rs2002651756109770SUMF2ENSG00000129103.131.617E-60.01-21925gtex_brain_ba24
rs2016724756110766SUMF2ENSG00000129103.131.982E-60.01-20929gtex_brain_ba24
rs58251663756111475SUMF2ENSG00000129103.138.997E-70.01-20220gtex_brain_ba24
rs4424212756117409SUMF2ENSG00000129103.137.492E-70.01-14286gtex_brain_ba24
rs4427122756117707SUMF2ENSG00000129103.137.495E-70.01-13988gtex_brain_ba24
rs6960348756124240SUMF2ENSG00000129103.137.555E-70.01-7455gtex_brain_ba24
rs12671494756125527SUMF2ENSG00000129103.137.566E-70.01-6168gtex_brain_ba24
rs766334756126713SUMF2ENSG00000129103.137.905E-70.01-4982gtex_brain_ba24
rs2014042756126947SUMF2ENSG00000129103.137.908E-70.01-4748gtex_brain_ba24
rs3813505756132122SUMF2ENSG00000129103.137.951E-70.01427gtex_brain_ba24
rs7793614756133204SUMF2ENSG00000129103.137.96E-70.011509gtex_brain_ba24
rs4585698756134265SUMF2ENSG00000129103.137.972E-70.012570gtex_brain_ba24
rs13242830756134501SUMF2ENSG00000129103.132.071E-60.012806gtex_brain_ba24
rs4345511756135458SUMF2ENSG00000129103.138.206E-70.013763gtex_brain_ba24
rs9767946756135970SUMF2ENSG00000129103.131.71E-60.014275gtex_brain_ba24
rs34809359756138322SUMF2ENSG00000129103.138.01E-70.016627gtex_brain_ba24
rs13244654756146956SUMF2ENSG00000129103.131.517E-60.0115261gtex_brain_ba24
rs2242509756151526SUMF2ENSG00000129103.137.967E-70.0119831gtex_brain_ba24
rs12673255756158581SUMF2ENSG00000129103.137.959E-70.0126886gtex_brain_ba24
rs13438048756161138SUMF2ENSG00000129103.137.959E-70.0129443gtex_brain_ba24
rs12536548756163988SUMF2ENSG00000129103.137.959E-70.0132293gtex_brain_ba24
rs74917128756165202SUMF2ENSG00000129103.139.649E-70.0133507gtex_brain_ba24
rs60462402756165311SUMF2ENSG00000129103.133.546E-70.0133616gtex_brain_ba24
rs12537948756165768SUMF2ENSG00000129103.137.959E-70.0134073gtex_brain_ba24
rs6947671756167991SUMF2ENSG00000129103.137.959E-70.0136296gtex_brain_ba24
rs12668193756172378SUMF2ENSG00000129103.138.716E-70.0140683gtex_brain_ba24
rs6971804756173816SUMF2ENSG00000129103.137.893E-70.0142121gtex_brain_ba24
rs28558245756175923SUMF2ENSG00000129103.137.82E-70.0144228gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
U2AF20.960.97
DVL30.950.95
DGCR140.950.95
DAXX0.940.94
RBM100.940.95
CXXC10.940.95
EWSR10.940.97
AC011498.30.940.95
PRKCSH0.940.94
RANBP30.940.94
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.81-0.88
MT-CO2-0.80-0.88
AF347015.27-0.78-0.88
AF347015.33-0.78-0.87
MT-CYB-0.77-0.85
AF347015.8-0.75-0.85
C5orf53-0.74-0.76
AF347015.21-0.73-0.88
FXYD1-0.73-0.82
AF347015.2-0.73-0.85

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 2717All SZGR 2.0 genes in this pathway
REACTOME GLYCOSPHINGOLIPID METABOLISM 3822All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPID METABOLISM 198112All SZGR 2.0 genes in this pathway
REACTOME THE ACTIVATION OF ARYLSULFATASES 125All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518242All SZGR 2.0 genes in this pathway
REACTOME SPHINGOLIPID METABOLISM 6940All SZGR 2.0 genes in this pathway
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION 188116All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN 391222All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE UP 14985All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718401All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445257All SZGR 2.0 genes in this pathway