Summary ?
GeneID25871
SymbolC3orf17
SynonymsNEPRO|NET17
Descriptionchromosome 3 open reading frame 17
ReferenceHGNC:HGNC:24496|Ensembl:ENSG00000163608|HPRD:08524|Vega:OTTHUMG00000159286
Gene typeprotein-coding
Map location3q13.2
Pascal p-value0.485
Sherlock p-value0.673
Fetal beta0.953
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.04359 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.04047 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg028561243112736847C3orf175.386E-4-0.3970.048DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
WDR480.970.97
HMG20A0.960.97
CTCF0.960.98
YTHDF20.960.96
ZNF7760.960.96
SUPT16H0.960.97
ZNF518B0.960.97
PHF200.960.96
WDR820.960.97
VEZT0.960.96
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FXYD1-0.78-0.92
MT-CO2-0.77-0.91
AF347015.31-0.77-0.89
AIFM3-0.77-0.81
TSC22D4-0.76-0.83
S100B-0.76-0.85
AF347015.33-0.75-0.86
IFI27-0.75-0.89
AF347015.27-0.75-0.86
HSD17B14-0.75-0.83

Section III. Gene Ontology annotation

Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP 236139All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344180All SZGR 2.0 genes in this pathway
NOUZOVA TRETINOIN AND H4 ACETYLATION 14385All SZGR 2.0 genes in this pathway