Gene Page: IFFO1
Summary ?
GeneID | 25900 |
Symbol | IFFO1 |
Synonyms | HOM-TES-103|IFFO |
Description | intermediate filament family orphan 1 |
Reference | MIM:610495|HGNC:HGNC:24970|Ensembl:ENSG00000010295|HPRD:09988|Vega:OTTHUMG00000141264 |
Gene type | protein-coding |
Map location | 12p13.3 |
Pascal p-value | 0.747 |
Sherlock p-value | 0.339 |
Fetal beta | -0.53 |
DMG | 2 (# studies) |
eGene | Myers' cis & trans |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 3 |
DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 3 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
---|---|---|---|---|---|---|---|
cg15316734 | 12 | 6657949 | IFFO1 | 4.554E-4 | 0.309 | 0.045 | DMG:Wockner_2014 |
cg22203219 | 12 | 6665335 | IFFO1 | 9.31E-10 | -0.022 | 1.11E-6 | DMG:Jaffe_2016 |
cg00082235 | 12 | 6664536 | IFFO1 | 6.93E-8 | -0.007 | 1.68E-5 | DMG:Jaffe_2016 |
eQTL annotation
SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs4864466 | chr4 | 54403975 | IFFO1 | 25900 | 0.16 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
WDR85 | 0.90 | 0.87 |
WDR73 | 0.89 | 0.87 |
UCKL1 | 0.88 | 0.89 |
TRABD | 0.87 | 0.86 |
CDK5RAP3 | 0.87 | 0.86 |
KLHL17 | 0.87 | 0.87 |
WDR59 | 0.87 | 0.86 |
SFI1 | 0.86 | 0.84 |
CPSF3L | 0.86 | 0.86 |
ANKS3 | 0.86 | 0.82 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
AF347015.31 | -0.68 | -0.73 |
AF347015.27 | -0.67 | -0.74 |
MT-CO2 | -0.65 | -0.70 |
AF347015.8 | -0.64 | -0.70 |
MT-CYB | -0.63 | -0.69 |
AF347015.21 | -0.63 | -0.75 |
AF347015.15 | -0.62 | -0.69 |
AF347015.33 | -0.61 | -0.66 |
AF347015.2 | -0.61 | -0.69 |
IFI27 | -0.57 | -0.64 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
HOLLMANN APOPTOSIS VIA CD40 DN | 267 | 178 | All SZGR 2.0 genes in this pathway |
ONKEN UVEAL MELANOMA UP | 783 | 507 | All SZGR 2.0 genes in this pathway |
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP | 351 | 230 | All SZGR 2.0 genes in this pathway |
ZHONG RESPONSE TO AZACITIDINE AND TSA UP | 183 | 119 | All SZGR 2.0 genes in this pathway |
ZHOU INFLAMMATORY RESPONSE LIVE DN | 384 | 220 | All SZGR 2.0 genes in this pathway |
ZHOU INFLAMMATORY RESPONSE FIMA DN | 284 | 156 | All SZGR 2.0 genes in this pathway |
PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
SHEPARD CRUSH AND BURN MUTANT UP | 197 | 110 | All SZGR 2.0 genes in this pathway |
PENG LEUCINE DEPRIVATION DN | 187 | 122 | All SZGR 2.0 genes in this pathway |
PENG RAPAMYCIN RESPONSE DN | 245 | 154 | All SZGR 2.0 genes in this pathway |
PENG GLUTAMINE DEPRIVATION DN | 337 | 230 | All SZGR 2.0 genes in this pathway |
KUNINGER IGF1 VS PDGFB TARGETS UP | 82 | 51 | All SZGR 2.0 genes in this pathway |
BOYLAN MULTIPLE MYELOMA D DN | 78 | 34 | All SZGR 2.0 genes in this pathway |
TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP | 271 | 165 | All SZGR 2.0 genes in this pathway |
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | All SZGR 2.0 genes in this pathway |
FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |