Gene Page: MTHFD1L
Summary ?
| GeneID | 25902 |
| Symbol | MTHFD1L |
| Synonyms | FTHFSDC1|MTC1THFS|dJ292B18.2 |
| Description | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like |
| Reference | MIM:611427|HGNC:HGNC:21055|Ensembl:ENSG00000120254|HPRD:09967|Vega:OTTHUMG00000015828 |
| Gene type | protein-coding |
| Map location | 6q25.1 |
| Pascal p-value | 0.009 |
| Sherlock p-value | 0.43 |
| eGene | Myers' cis & trans |
| Support | Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7763414 | chr6 | 151405376 | MTHFD1L | 25902 | 0.09 | cis | ||
| rs7742684 | chr6 | 151405390 | MTHFD1L | 25902 | 0.04 | cis |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| BCL11A | 0.88 | 0.75 |
| DSCAML1 | 0.88 | 0.73 |
| TMPRSS13 | 0.87 | 0.61 |
| FOXO6 | 0.87 | 0.82 |
| MYO5B | 0.87 | 0.67 |
| NFYA | 0.86 | 0.79 |
| FEZF2 | 0.86 | 0.64 |
| FOXG1B | 0.86 | 0.82 |
| AUTS2 | 0.85 | 0.88 |
| SCRT2 | 0.85 | 0.78 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C5orf53 | -0.50 | -0.84 |
| PPAP2A | -0.50 | -0.64 |
| SERPINB6 | -0.49 | -0.62 |
| TNFSF12 | -0.49 | -0.62 |
| FBXO2 | -0.48 | -0.67 |
| HLA-F | -0.48 | -0.71 |
| PTH1R | -0.48 | -0.63 |
| TMEM54 | -0.48 | -0.63 |
| AP003117.1 | -0.48 | -0.65 |
| ME1 | -0.48 | -0.66 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG GLYOXYLATE AND DICARBOXYLATE METABOLISM | 16 | 12 | All SZGR 2.0 genes in this pathway |
| KEGG ONE CARBON POOL BY FOLATE | 17 | 12 | All SZGR 2.0 genes in this pathway |
| LIU SOX4 TARGETS DN | 309 | 191 | All SZGR 2.0 genes in this pathway |
| VECCHI GASTRIC CANCER EARLY UP | 430 | 232 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP | 633 | 376 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA ANAPLASTIC UP | 722 | 443 | All SZGR 2.0 genes in this pathway |
| LIAO METASTASIS | 539 | 324 | All SZGR 2.0 genes in this pathway |
| SHEPARD BMYB MORPHOLINO DN | 200 | 112 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS LATE PROGENITOR | 544 | 307 | All SZGR 2.0 genes in this pathway |
| RODWELL AGING KIDNEY NO BLOOD UP | 222 | 139 | All SZGR 2.0 genes in this pathway |
| RODWELL AGING KIDNEY UP | 487 | 303 | All SZGR 2.0 genes in this pathway |
| SANSOM APC TARGETS | 212 | 121 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER WITH H3K9ME3 DN | 120 | 71 | All SZGR 2.0 genes in this pathway |
| LEE RECENT THYMIC EMIGRANT | 227 | 128 | All SZGR 2.0 genes in this pathway |
| DUTERTRE ESTRADIOL RESPONSE 6HR UP | 229 | 149 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS DN | 882 | 538 | All SZGR 2.0 genes in this pathway |
| HUANG GATA2 TARGETS DN | 72 | 52 | All SZGR 2.0 genes in this pathway |
| KRIEG HYPOXIA NOT VIA KDM3A | 770 | 480 | All SZGR 2.0 genes in this pathway |