Gene Page: GAP43

Summary
GeneID  2596
Symbol  GAP43
Synonyms  B-50|PP46
Description  growth associated protein 43
See related  HGNC:4140|MIM:162060|Ensembl:ENSG00000172020|HPRD:01198|
Locus tag  -
Gene type  protein-coding
Map location  3q13.1-q13.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.04359 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.04047 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenics, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0265 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005516calmodulin bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0016198axon choice point recognitionIEAneuron, axon (GO term level: 14)-
GO:0010001glial cell differentiationIEAGlial (GO term level: 8)-
GO:0007399nervous system developmentIEAneurite (GO term level: 5)-
GO:0001558regulation of cell growthIEA-
GO:0007205activation of protein kinase C activityTAS3272162 
GO:0009611response to woundingTAS3272162 
GO:0007275multicellular organismal developmentIEA-
GO:0040008regulation of growthIEA-
GO:0045165cell fate commitmentIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042995cell projectionIEAaxon (GO term level: 4)-
GO:0030424axonIEAneuron, axon, Neurotransmitter (GO term level: 6)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CALM1CALML2 | CAMI | DD132 | PHKDcalmodulin 1 (phosphorylase kinase, delta)GAP-43 interacts with CaM.BIND8872303 
PLCD1-phospholipase C, delta 1Affinity Capture-WesternBioGRID12805215 
RABEP1RAB5EP | RABPT5rabaptin, RAB GTPase binding effector protein 1-HPRD,BioGRID9742146 
SPTAN1(ALPHA)II-SPECTRIN | FLJ44613 | NEASspectrin, alpha, non-erythrocytic 1 (alpha-fodrin)-HPRD10521589 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_NCADHERIN_PATHWAY 3332All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_UP 14699All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP 238135All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_12HR_DN 5745All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
POMEROY_MEDULLOBLASTOMA_PROGNOSIS_UP 4730All SZGR genes in this pathway
NADLER_HYPERGLYCEMIA_AT_OBESITY 5835All SZGR genes in this pathway
RORIE_TARGETS_OF_EWSR1_FLI1_FUSION_DN 3023All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_UP 178111All SZGR genes in this pathway
YIH_RESPONSE_TO_ARSENITE_C3 3624All SZGR genes in this pathway
LEIN_NEURON_MARKERS 6945All SZGR genes in this pathway
KONDO_PROSTATE_CANCER_WITH_H3K27ME3 19693All SZGR genes in this pathway
IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_UP 12692All SZGR genes in this pathway
NUTT_GBM_VS_AO_GLIOMA_UP 4634All SZGR genes in this pathway
HOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_UP 3624All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3 445257All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_5 3022All SZGR genes in this pathway
HOELZEL_NF1_TARGETS_UP 13993All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_UP 163111All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-130/301288294m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-148/152289295m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-1855157m8hsa-miR-185brainUGGAGAGAAAGGCAGUUC
miR-191385391m8hsa-miR-191brainCAACGGAAUCCCAAAAGCAGCU
miR-25/32/92/363/367377383m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-3701821881Ahsa-miR-370brainGCCUGCUGGGGUGGAACCUGG
miR-378*4014071Ahsa-miR-422bCUGGACUUGGAGUCAGAAGGCC
hsa-miR-422aCUGGACUUAGGGUCAGAAGGCC
miR-4521561621Ahsa-miR-452UGUUUGCAGAGGAAACUGAGAC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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